ATSDR - Toxic Substances - 1,4-Dioxane
Skip directly to search Skip directly to A to Z list Skip directly to site content Skip directly to page options

1,4-Dioxane

CAS ID #: 123-91-1

Affected Organ Systems: Hepatic (Liver), Ocular (Eyes), Renal (Urinary System or Kidneys)

Cancer Classification: EPA: Likely to be carcinogenic to humans. IARC: Possibly carcinogenic to humans. NTP: Reasonably anticipated to be a human carcinogen

Please contact NTP, IARC, or EPA’s IRIS Hotline with questions on cancer and cancer classification.

Chemical Classification: None

Summary: 1,4-Dioxane is a clear liquid that easily dissolves in water. It is used primarily as a solvent in the manufacture of chemicals and as a laboratory reagent; 1,4-dioxane also has various other uses that take advantage of its solvent properties. 1,4-Dioxane is a trace contaminant of some chemicals used in cosmetics, detergents, and shampoos. However, manufacturers now reduce 1,4-dioxane from these chemicals to low levels before these chemicals are made into products used in the home.

Community Members 

Community Members
  • ToxFAQs

    Fact sheet that answers the most frequently asked questions about a contaminant and its health effects.

  • Public Health Statement

    Summary about a hazardous substance taken from Chapter One of its respective ATSDR Toxicological Profile.

  • Emergency Responders 

    Emergency Responders
  • Medical Management Guidelines (MMG) for Acute Chemical Exposure

    Medical Management Guideline (MMG) for Acute Chemical Exposure Publication intended to aid emergency department physicians and other emergency healthcare professionals who manage acute exposures.

  • Toxicological and Health Professionals 

    Toxicological and Health Professionals
  • Toxicological Profile

    Succinctly characterizes the toxicologic and adverse health effects information for a hazardous substance.

  • ToxGuide (PDF, 132KB*)

    Quick reference guide providing information such as chemical and physical properties, sources of exposure, routes of exposure, minimal risk levels, children's health, and health effects for a substance.

  • Top of Page

    Contact Us:
    • Agency for Toxic Substances and Disease Registry
      4770 Buford Hwy NE
      Atlanta, GA 30341
    • 800-CDC-INFO
      (800-232-4636)
      TTY: (888) 232-6348
    • New Hours of Operation
      8am-8pm ET/Monday-Friday
      Closed Holidays
      Contact CDC-INFO
    USA.gov: The U.S. Government's Official Web PortalDepartment of Health and Human Services
    Agency for Toxic Substances and Disease Registry, 4770 Buford Hwy NE, Atlanta, GA 30341
    Contact CDC: 800-232-4636 / TTY: 888-232-6348

    A-Z Index

    1. A
    2. B
    3. C
    4. D
    5. E
    6. F
    7. G
    8. H
    9. I
    10. J
    11. K
    12. L
    13. M
    14. N
    15. O
    16. P
    17. Q
    18. R
    19. S
    20. T
    21. U
    22. V
    23. W
    24. X
    25. Y
    26. Z
    27. #