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SSRI toxicity
From WikEM
(Redirected from SSRI Toxicity)
Contents
Background
- Most serious adverse effect is potential to produce Serotonin Syndrome
- Fatalities are uncommon with pure overdoses
Clinical Features
- Nausea and vomiting
- Sedation
- Tremor
- Sinus tachycardia
- QRS, QT prolongation (citalopram only)
- Serotonin syndrome
Differential Diagnosis
Anticholinergic toxicity
- Medications
- Atropine
- Antihistamines
- Antidepressants
- Antipsychotics
- Muscle relaxants
- Anti-Parkinsonians
- Plants
- Jimson weed (Devil's trumpet)
- Amanita mushroom
Management
- GI decontamination
- Activated charcoal x1
- Gastric lavage unnecessary
Disposition
- Consider admission for patients who are tachycardic or lethargic 6hr after ingesion
