Fluocortin

Fluocortin
Clinical data
Other names	6α-fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20,21-trione
AHFS/Drugs.com	International Drug Names
ATC code	D07AB04 (WHO) ;
Pharmacokinetic data
Bioavailability	80% i.v.
Elimination half-life	1.3 hr.
Identifiers
	IUPAC name 2-[(6S,8S,9S,10R,11S,13S,14S,16R,17S)-6-Fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]-2-oxoacetic acid;
CAS Number	33124-50-4 ;
PubChem CID	22875828;
ChemSpider	18865233;
UNII	03837V0H1Y;
KEGG	D07972 ;
CompTox Dashboard (EPA)	DTXSID30186785 ;
ECHA InfoCard	100.046.698
Chemical and physical data
Formula	C22H27FO5
Molar mass	390.45 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@@H]1C[C@H]2[C@@H]3C[C@@H](C4=CC(=O)C=C[C@@]4([C@H]3[C@H](C[C@@]2([C@H]1C(=O)C(=O)O)C)O)C)F;
	InChI InChI=1S/C22H27FO5/c1-10-6-13-12-8-15(23)14-7-11(24)4-5-21(14,2)18(12)16(25)9-22(13,3)17(10)19(26)20(27)28/h4-5,7,10,12-13,15-18,25H,6,8-9H2,1-3H3,(H,27,28)/t10-,12+,13+,15+,16+,17-,18-,21+,22+/m1/s1; Key:PUWHHWCHAVXSIG-NCLPIGKXSA-N;
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Fluocortin is a corticosteroid. It is similar to fluocortolone, but with one more keto group.

References

Tauber, U.; D. Haack; B. Nieuweboer; G. Kloss; P. Vecsei; H. Wendt (1984). "The pharmacokinetics of fluocortolone and prednisolone after intravenous and oral administration". Int J Clin Pharmacol Ther Toxicol. 22 (1): 48–55. PMID 6698661.

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