The mother's problem list includes pregnancy and anxiety; the child's, frequent otitis media (status post myringotomy and tympanostomy tube placement) and frequent upper respiratory infections.
You will need information on TCE toxicity, including reproductive and developmental effects; information on TCE contamination of the family's drinking water, including duration and level of contamination; copies of information provided to the family by the municipal water company; and responses, if any, from local and state health agencies.
More information for this answer can be found in the sections “How Are People Exposed to Trichloroethylene?” and “What Are the Physiological Effects of Trichloroethylene?”
None of the symptoms described in the case indicate serious illness. However, you should reassure the family that you will perform a complete physical examination with appropriate testing at the next visit. In response to concern about the child's infections, you should indicate that you will collect information about possible TCE effects on the immune system. Explain to the parents that tests of immune function are often difficult to interpret and might not be appropriate. You might indicate that you will consult sources of information on TCE's effects on pregnancy. It is important to maintain a balance between reassurance that the unborn child is probably not affected by the water contamination and concern for the possible risk to the fetus. Reassurance should not, however, appear to trivialize the family's fears. It would also be appropriate to discuss that no evaluation, however thorough, can totally exclude the possibility that a person might develop an illness, including cancer.
More information for this answer can be found in the section “What Are the Physiological Effects of Trichloroethylene?”
Possible sources of the family's TCE exposure include home drinking water (ingestion and dermal and inhalation exposure during bathing), the father's workplace (inhalation), and the daughter's day-care center (inhalation). Other sources would be washing dishes, laundry, or any other use of hot water in the home; the use of TCE-containing consumer products such as correction fluid, spot removers, and so forth.
More information for this answer can be found in the section “How Are People Exposed to Trichloroethylene?”
All members of the family described in the case study are at increased risk for adverse effects from TCE exposure.
More information for this answer can be found in the section “How Are People Exposed to Trichloroethylene?”
The most convenient biologic indicators of TCE exposure are the urinary metabolites, trichloroethanol and trichloroacetic acid. These metabolites are not specific to TCE, however, because they are also metabolites of tetrachloroethylene (perchloroethylene), 1,1,1-trichloroethane (methyl chloroform), and certain medications. TCE itself can be measured directly in blood or exhaled air, but because of the difficulty of obtaining samples, such measurements are not indicated here.
More information for this answer can be found in the section “What Laboratory Tests Can Assist in the Evaluation of Patients Exposed to Trichloroethylene?”
To properly interpret any of the tests mentioned in answer 6, knowledge of the time lapse between exposure and collection is necessary. To prevent contamination or sample loss (evaporation or adsorption), the proper collection, handling, storage, and transportation procedures must be followed. It is likely that members of this family would have elevated levels of TCE or its metabolites, above background levels, for a few hours after exposure, for instance, after they shower. However, there are no appropriate reference values currently available for a health risk assessment.
More information for this answer can be found in the section “What Laboratory Tests Can Assist in the Evaluation of Patients Exposed to Trichloroethylene?”
No further studies are indicated for TCE exposure. A workup for fatigue can indicate additional tests.
- Evidence from animal and epidemiologic studies suggests that several reproductive and developmental toxicity end points may be associated with TCE exposure, including infertility in males and females, impaired fetal growth, and cardiac teratogenesis. Invasive procedures are therefore justified in this case.
More information for this answer can be found in the section “What Are the Physiological Effects of Trichloroethylene?”
No. A survey of infections in children under three years of age over a September-to-March period found an average of 2.5 total infections and more than one episode of otitis media per child (1.4 episodes per child for those in day care). More than 3% of the children in day care were hospitalized for tympanostomies (Bell, Gleiber et al. 1989). The child described in the case study appears to have an above-average rate of infections, but they are not frequent enough to suggest immunologic impairment.
No. Immunocompetence tests are not appropriate because no evidence of immune function abnormalities has been found in this case. It is uncertain about TCE drinking water exposures and immune system abnormalities given the lack of quality studies on this question. Primary immunodeficiency is suspected in an infant who has repeated upper respiratory tract or other infections. It is also suspected if repeated infection occurs in a child who has had little exposure to infectious agents, or any child with unusual infections, incomplete clearing of infections, growth failure, hepatosplenomegaly, or features associated with specific immunodeficiency disorders, such as ataxia or telangiectasia. The child described in the case study has none of these indications.
More information for this answer can be found in the section “What Are the Physiological Effects of Trichloroethylene?”
Although EPA has not issued an emission standard for TCE, New York State has set a guideline for TCE air emission of 5 µg/m³. Assuming discussions with the owner or operator of the shop adjacent to the day-care center have not been effective in reducing the level of ambient TCE, the community's air pollution control center should be notified. States might allow this control under the jurisdiction of local air pollution control districts, county health departments, or other local agencies. The agency responsible for enforcement of air standards should be contacted to investigate possible release of TCE onto the day-care center property.
More information for this answer can be found in the section “What Are the U.S. Standards for Trichloroethylene Exposure?”