ATSDR's Substance-Specific Priority Data Needs - Unfilled Data

Substances	PDN Description	Status ⁽¹⁾
Acrolein	Exposure levels in humans living near hazardous waste sites and other populations Exposure levels in children Dose-response data for chronic-duration⁽⁴⁾ via inhalation exposure	Unfilled
Aldrin/Dieldrin	Potential candidate for subregistry of exposed persons	Unfilled
Aluminum	Dose-response data for acute-duration⁽²⁾ via oral exposure Exposure via environmental media for humans living near hazardous waste sites Exposure via environmental media for children living near hazardous waste sites Exposure via environmental media for adults and children who do not live near hazardous waste sites (as controls)	Unfilled
Arsenic	Comparative toxicokinetic studies to determine if an appropriate animal species can be identified Half-lives in surface water, groundwater	Unfilled
Asbestos	Epidemiologic studies of individuals occupationally exposed to asbestos levels lower than those experienced before the institution of current occupational standards governing the use of asbestos, but higher than current levels in the general population. These studies should be performed in conjunction with the immunotoxicity studies Immunotoxicity studies of individuals occupationally exposed to asbestos Development of human and rat lung retention models to aid in extrapolating between rat and human data Exposure levels, fiber size distribution, and asbestos fiber type in areas with natural geologic deposits of friable asbestos and at hazardous waste sites. Also, techniques for estimating air levels of asbestos from soil concentrations and activity scenarios Exposure levels in humans living near hazardous waste sites and in other populations, such as humans living in areas with naturally high levels of friable asbestos	Unfilled
Barium	Dose- response data for acute-duration⁽²⁾ via oral exposure	Unfilled
Benzene	Dose-response data in animals for acute- and intermediate(3)-duration oral exposure. The intermediate-duration study should include an extended reproductive organ histopathology Prenatal developmental toxicity study via oral exposure Neurotoxicology battery of tests via oral exposure	Unfilled
Benzidine	Dose-response data for acute- and intermediate-duration exposure via the oral route (the study of intermediate-duration exposure should include evaluation of reproductive and endocrine organ histopathology, lymphoid tissues histopathology as well as examination of relevant blood components, and nervous system histopathology) Exposure levels in humans living near hazardous waste sites Exposure levels in children Potential candidate for subregistry of exposed persons	Unfilled
Beryllium	Dose-response data in animals for acute- and intermediate-duration inhalation exposures. The intermediate-duration study should include extended reproductive organ histopathology Prenatal developmental toxicity study via inhalation exposure Environmental fate in air; factors affecting bioavailability in air Immunotoxicology battery of tests following oral exposure Potential candidate for subregistry of exposed persons	Unfilled
Carbon tetrachloride	Dose-response data in animals for chronic oral exposure. The study should include extended reproductive organ and nervous tissue histopathology Potential candidate for subregistry of exposed persons	Unfilled
Chlordane	Bioavailability studies following ingestion of contaminated media Potential candidate for subregistry of exposed persons	Unfilled
Chlorinated dibenzo-p-dioxins (CDDs)	Comparative toxicokinetic studies examining the relative absorption of CDDs across exposure routes and the relative contribution of each exposure route to total body burdens	Unfilled
Chloroethane	Potential candidate for subregistry of exposed persons	Unfilled
Chloroform	Potential candidate for subregistry of exposed persons	Unfilled
Chromium	Dose-response data in animals for acute-duration exposure to chromium (III) via oral exposure Multigeneration reproductive toxicity study via oral exposure to chromium (III) Immunotoxicology battery of tests following oral exposure to chromium (III) and (VI) Prenatal developmental toxicity study via oral exposure to chromium (III)	Unfilled
Cresols	Dose-response data for acute-duration via oral exposure Exposure levels in humans living near hazardous waste sites and other populations Exposure levels in children	Unfilled
Cyanide	Potential candidate for subregistry of exposed persons	Unfilled
Diazinon	Developmental toxicity data via oral exposure	Unfilled
1,2-dibromo-3-chloropropane	Dose-response data in animals for acute-duration exposure via the oral route (including reproductive organ histopathology) Dose-response data in animals for chronic-duration exposure via the oral route (including reproductive organ histopathology) Prenatal developmental toxicity study via oral exposure Immunotoxicology testing battery via oral exposure Neurotoxicology testing battery via oral exposure Potential candidate for subregistry of exposed persons	Unfilled
1,2-Dibromoethane	Dose-response data in animals for intermediate-duration exposure by the oral route (the study should include evaluation of neuropathology and observation for overt signs of neurotoxicity) Multigeneration reproductive toxicity studies via oral exposure Prenatal toxicity studies via oral exposure Exposure levels in humans living near hazardous waste sites and in other populations, such as workers exposed to 1,2-dibromoethane Exposure levels in children Potential candidate for subregistry of exposed persons	Unfilled
1,2-Dichloroethane	Dose-response data in animals for acute-duration exposure by the inhalation route, including a comparison of young and adult animals Dose-response data in animals for acute-duration exposure by the oral route, including a comparison of young and adult animals Dose-response data in animals for intermediate-duration exposure by the inhalation route (the study should be performed in conjunction with the neurotoxicology battery of tests) Neurotoxicology battery of tests following oral exposure Dose-response data in animals for chronic-duration exposure by the oral route Prenatal developmental toxicity data for inhalation exposure (assessment of developmental cardiotoxicity and neurotoxicity) Prenatal developmental toxicity data for oral exposure (assessment of developmental cardiotoxicity and neurotoxicity) Additional analyses and studies for comparative toxicokinetics across species, ages, routes, and durations Children’s susceptibility Exposure levels in children Potential candidate for subregistry of exposed persons	Unfilled
1,1-Dichloroethene	Carcinogenicity studies in two species following inhalation exposure Reproductive toxicity studies assessing male and female end points following inhalation exposure Immunotoxicology battery of tests following oral exposure Battery of neurobehavioral tests following inhalation exposure Children’s susceptibility Exposure levels in children Potential candidate for subregistry of exposed persons	Unfilled
Dichloropropenes	Dose-response data for acute-duration via inhalation exposure Immunotoxicity battery via inhalation exposure	Unfilled
DDT	Dose-response data in animals for chronic-duration oral exposure Comparative toxicokinetic study (across routes/species) Potential candidate for subregistry of exposed persons	Unfilled
Di(2-ethylhexyl) phthalate	Potential candidate for subregistry of exposed persons	Unfilled
Di-n-butyl phthalate	Dose-response data in animals for chronic-duration exposure via the oral route Carcinogenicity studies via oral exposure Bioavailability in contaminated environmental media near hazardous waste sites Potential candidate for subregistry of exposed persons	Unfilled
Disulfoton	Exposure levels of disulfoton in tissues/fluids for populations living near hazardous waste sites and other populations, such as exposed workers Disulfoton should be considered as a potential candidate for a subregistry of exposed persons	Unfilled
Endosulfan (α,β, and sulfate)	Acute-duration oral exposure studies Data on sensitive neurologic end points following oral exposure Potential candidate for subregistry of exposed persons	Unfilled
Endrin/endrin aldehyde	Dose-response animal data for acute oral exposure to endrin Multigeneration reproductive toxicity studies via oral exposure to endrin Accurately describe the toxicokinetics of endrin and its degradation products and identify the animal species to be used as the most appropriate model for human exposure Accurately describe the environmental fate of endrin, including environmental breakdown products and rates, media half-lives, and chemical and physical properties of the breakdown products that help predict mobility and volatility Potential candidate for subregistry of exposed persons	Unfilled
Ethylbenzene	Dose-response data for acute-duration exposure by the oral route Prenatal developmental study with continued assessment of offspring during postnatal development following oral exposure Potential candidate for subregistry of exposed persons	Unfilled
Guthion	Studies of developmental toxicity via oral exposure with emphasis on neurodevelopmental toxicity.	Unfilled
Heptachlor/ heptachlor epoxide	Potential candidate for subregistry of exposed persons	Unfilled
Hexachlorobutadiene	Dose-response data in animals for acute-duration exposure via the oral route Exposure levels in humans living near hazardous waste sites and other populations, such as exposed workers Environmental fate studies that determine the extent to which hexachlorobutadiene volatilizes from soil, and studies that determine the reactions and rates which drive degradation in soil Bioavailability studies in soil and plants Potential candidate for subregistry of exposed persons	Unfilled
Hexachlorocyclohexane (α, β, γ, and δ)	Mechanistic studies on the reproductive toxicity and immunotoxicity of hexachlorocyclohexane Potential candidate for subregistry of exposed persons	Unfilled
Manganese	Relative bioavailability of different manganese compounds and bioavailability of manganese from soil	Unfilled
Mercury	Potential candidate for subregistry of exposed persons	Unfilled
Methoxychlor	Exposure levels of methoxychlor and primary metabolites in humans living near hazardous waste sites and in those individuals with the potential to ingest it Evaluate the fate, transport, and levels of the degradation products of methoxychlor in soil Potential candidate for subregistry of exposed persons	Unfilled
Methylene chloride	Potential candidate for subregistry of exposed persons	Unfilled
Nickel	Dose-response data in animals for acute- and intermediate-duration oral exposures Neurotoxicology battery of tests via oral exposure Bioavailability of nickel from soil Potential candidate for subregistry of exposed persons	Unfilled
Pentachlorophenol	Comparative toxicokinetic studies Potential candidate for subregistry of exposed persons	Unfilled
Phenol	Exposure levels in humans living near hazardous waste sites and other populations Exposure levels in children	Unfilled
Polychlorinated biphenyls (PCBs)	Biodegradation of PCBs in water; bioavailability of PCBs in air, water, and soil Dose-response data in animals for acute- and intermediate-duration inhalation exposures. The intermediate-duration study should include extended reproductive organ histopathology Potential candidate for subregistry of exposed persons	Unfilled
Polycyclic aromatic hydrocarbons (PAHs) (Includes 15 substances)	Potential candidate for subregistry of exposed persons	Unfilled
Selenium	Dose-response data in animals for acute-duration oral exposure Immunotoxicology battery of tests via oral exposure Potential candidate for subregistry of exposed persons	Unfilled
1,1,2,2-Tetrachloroethane	Prenatal developmental toxicity study by the oral route Immunotoxicity battery following oral exposure Mammalian in vivo genotoxicity assays Exposure levels in children Potential candidate for subregistry of exposed persons	Unfilled
Tetrachloroethylene	Potential candidate for subregistry of exposed persons	Unfilled
Toluene	Potential candidate for subregistry of exposed persons Neurotoxicology battery of tests via oral exposure	Unfilled
Toxaphene	Identify the long-term health consequences of exposure to environmental toxaphene via oral exposure Neurotoxicity studies for chronic-duration via oral route of exposure Exposure levels in humans living in areas near hazardous waste sites with toxaphene and in those individuals with the potential to ingest it Potential candidate for subregistry of exposed persons	Unfilled
Vinyl chloride	Dose-response data in animals for chronic-duration inhalation exposure Mitigation of vinyl chloride-induced toxicity Exposure levels in humans living near hazardous waste sites and other populations, such as exposed workers Potential candidate for subregistry of exposed persons	Unfilled
Xylenes	Neurotoxicology battery of tests following oral exposure Two-generation reproductive study following oral exposure Potential candidate for subregistry of exposed persons	Unfilled
Zinc	Carcinogenicity testing (2-year bioassay) via oral exposure Exposure levels in humans living near hazardous waste sites and other populations, such as exposed workers Potential candidate for subregistry of exposed persons	Unfilled

⁽¹⁾ Currently, no data have been identified to fill the priority data need.

⁽²⁾ Acute-duration exposure = 14 days or less.

⁽³⁾ Intermediate-duration exposure = 15 -364 days

⁽⁴⁾ Chronic-duration exposure = 365 days or more.

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Page last reviewed: August 31, 2010
Page last updated: August 31, 2010
Content source:
- Agency for Toxic Substances and Disease Registry