ABCs Report: Streptococcus pneumoniae, 2014

May 20, 2016: Content on this page kept for historical reasons.

Active Bacterial Core Surveillance (ABCs): Emerging Infections Program Network

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ABCs Areas

California (San Francisco County and children < 18 years in Alameda and Contra Costa counties); Colorado (5 county Denver area); Connecticut; Georgia (20 county Atlanta area); Maryland (6 county Baltimore area); Minnesota; New Mexico; New York (15 county Rochester and Albany areas and children <5 years in Erie county); Oregon (3 county Portland area); Tennessee (20 counties).

ABCs Population

The surveillance areas represent 31,328,211 persons.

Source: National Center for Health Statistics bridged-race vintage 2014 postcensal file

ABCs Case Definition

Invasive pneumococcal disease: isolation of Streptococcus pneumoniae from normally sterile site in resident of a surveillance area in 2014.

ABCs Methodology

ABCs personnel routinely contacted all microbiology laboratories serving acute care hospitals in their area to identify cases. Standardized case report forms that include information on demographic characteristics, clinical syndrome, and outcome of illness were completed for each identified case. Pneumococcal isolates were collected and sent to reference laboratories for susceptibility testing using CLSI methods and serotyping. Regular laboratory audits assessed completeness of active surveillance and detected additional cases.

Rates of invasive pneumococcal disease were calculated using population estimates for 2014 from the bridged-race vintage 2014 postcensal file. For national estimates, race-and age-specific rates of disease were applied from the aggregate surveillance area to the age and racial distribution of the 2014 U.S. population. Cases with missing data, excluding ethnicity, were multiply imputed using sequential regression imputation methods.^¶

Reported ABCs Profiles

Race	No.	(Rate*)
White	1,977	(8.3)
Black	647	(12.5)
Other	192	(8.0)

^* Per 100,000 population for ABCs areas

Age (years)	Cases No. (Rate*)	Deaths No. (Rate*)
< 1	66 (15.9)	2 (0.48)
1	43 (10.3)	0 (0.00)
2-4	80 (6.3)	1 (0.08)
5-17	77 (1.4)	3 (0.05)
18-34	193 (2.7)	13 (0.18)
35-49	407 (6.6)	43 (0.70)
50-64	919 (15.1)	100 (1.64)
65-74	458 (19.1)	58 (2.41)
75-84	334 (28.2)	41 (3.46)
≥ 85	239 (42.6)	45 (8.01)
Total	2,816 (9.0)	306 (0.98)

^* Per 100,000 population for ABCs areas

Syndrome	No.	(%*)
Meningitis	186	(6.6)
Bacteremia without focus	451	(16.0)
Pneumonia with bacteremia	1,983	(70.4)

^* Percent of cases

Antibiotic	S*	I†	R‡
Susceptibility	%	%	%
Penicillin	94.8	3.1	2.1
Cefotaxime	96.6	2.8	0.6
Erythromycin	68.3	0.4	31.3
TMP/Sulfa	80.7	9.6	9.8
Tetracycline	88.4	0	11.6
Levofloxacin	99.6	0	0.3
Vancomycin	100	0	0

Based on reference lab testing of 2,485 isolates.
^* Susceptible; ^† Intermediate; ^‡ Resistant based on year 2014 CLSI definitions

National Estimates of Invasive Disease

Cases: 29,100 (9.1/100,000)
Deaths: 3,250 (1.0/100,000)

Healthy People 2020 Update

Objective: Decrease the incidence of invasive pneumococcal infections to 12 per 100,000 persons less than 5 years of age and to 31 per 100,000 persons aged 65 and older.

Age (year)	2020 Objective	2013 Rate*
< 5	12/100,000	8.7/100,000
≥ 65	31/100,000	24.8/100,000

^* Per 100,000 U.S. population < 5 years or ≥ 65 years

Citation

Centers for Disease Control and Prevention. 2014. Active Bacterial Core Surveillance Report, Emerging Infections Program Network, Streptococcus pneumoniae, 2014.

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