Working Group Meeting July 18-19, 2005

Topics Chosen for Review at the July 18-19, 2005 Working Group Meeting

Screening for Hereditary Nonpolyposis Colorectal Cancer (HNPCC) in Newly Diagnosed Colorectal Cancer Patients – The evidence report will evaluate the efficacy and effectiveness of screening strategies for identifying HNPCC mutations in an identified high risk subset of individuals with newly diagnosed colorectal cancer. The review will include preliminary evaluations such as clinical and family history, immunohistochemical staining of fixed tumor tissue, or genetic testing for microsatellite instability (MSI) in tumor tissue that are used to select a subgroup of colorectal cancer patients for HNPCC mutation testing.

Testing for Cytochrome P450 Polymorphisms in Adults with Non-Psychotic Depression Prior to Treatment with Selective Serotonin Reuptake Inhibitors (SSRIs) – The evidence report will evaluate what is known about the analytic and clinical validity of this testing, and its efficacy and effectiveness in improving outcomes of drug treatment for non-psychotic depression.