Genomics Implementation

Fact Sheet: Implementing Evidence-based Genomic Tests and Family Health History [PDF 1.04 MB]

What public health can do now in human genomics to save lives and improve health

This page summarizes current information on genomic applications that are ready to be integrated into public health practice to save lives, improve health and quality of life. The focus at this time is on three Tier I applications: Hereditary Breast/Ovarian Cancer Syndrome, Lynch Syndrome and Familial Hypercholesterolemia, but information about other Tier I applications will be added in the near future. The page includes information about completed and ongoing projects spearheaded by state health departments and their partners, and recommendations from evidence based groups which can be applied at the state or local level. Please contact us at genetics@cdc.gov if you are aware of a statewide or other project not currently included which should be highlighted on this page.

Resources

• Implementing Public Health Genomics in Your State: Resources from the CDC Office of Public Health Genomics [PDF 2.95 MB], slide set from a Genetic Alliance and APHA Genomics Forum webinar
• Classification of Genomic Applications by Levels of Evidence
• State Implementation Activities Clickable Map
• Public Health Genomic Tier 1 Tool Kit
• Healthy People 2020 Genomics Objectives
• Search the Public Health Genomics Knowledge Base for Implementation Resources and Information

Reports

• Healthcare Special Issue “Implementation of Public Health Genomics”, 2015-2016
  • Expert and Advocacy Group Consensus Findings on the Horizon of Public Health Genetic Testing
    Stephen M. Modell et al, Healthcare 2016, 4(1), 14
  • Genomics in Public Health: Perspective from the Office of Public Health Genomics at the Centers for Disease Control and Prevention (CDC)
    Ridgely Fisk Green et al, Healthcare 2015, 3(3), 830-837
  • The Activities and Impact of State Programs to Address Hereditary Breast and Ovarian Cancer, 2011–2014
    Katrina F. Trivers et al. Healthcare 2015, 3(4), 948-963
  • Community-Based Family Health History Education: The Role of State Health Agencies in Engaging Medically Underserved Populations in Understanding Genomics and Risk of Chronic Disease
    Laura Senier et al. Healthcare 2015, 3(4), 995-1017
  • Screening for Familial Hypercholesterolemia in Children: What Can We Learn From Adult Screening Programs?
    Lidewij Henneman et al. Healthcare 2015, 3(4), 1018-1030
  • When is Genomic Testing Cost-Effective? Testing for Lynch Syndrome in Patients with Newly-Diagnosed Colorectal Cancer and Their Relatives
    Scott D. Grosse Healthcare 2015, 3(4), 860-878
• Priorities for Public Health Genomics: 2012-2017. [PDF 5.17 MB] University of Washington
• Report and Recommendations from the September 7, 2012 CDC Workshop: New Strategies in Public Health Genomics Actions to Save Lives Now [PDF 951.81 KB]. University of Michigan Center for Community and Public Health Genomics. APHA Genomics Forum
• CDC paper: Public health action in genomics is needed now beyond newborn screening. By S Bowen et al. Public Health Genomics 2012
• New strategies in public health in genomics beyond newborn screening: a working meeting 9/17/2012 and development of an action plan (CDC Blog)
• Current priorities for public health practice in addressing the role of human genomics in improving population health. Khoury MJ et al. Am J Prev Med 2011.

Videos and Podcasts

• A video resource: Genetics and BRCA in Primary Care (October 14,, 2014)
• A video resource: Public health genomics implementation to save lives – from national vision to state success (March 6, 2014)
• A video interview on Tier 1 genomic application and pioneer states (March 6, 2014)
• Using genomics to prevent cancer now (March 6, 2014)
• CDC Video: A Tiered Approach to Integrating Genomic Tests Into Your Practice (January 14, 2013)
• CDC Video: Cascade genetic screening and public health practice: an idea whose time has come (October 18, 2012)
• Hereditary Breast and Ovarian Cancer: BRCA and Your Patient (October 10,2011)
• Genetic Testing for Lynch Syndrome in Colorectal Cancer (February 7, 2011)
• Cascade screening for Familial Hypercholesterolemia (September 20, 2010)