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Registry of Toxic Effects of Chemical Substances (RTECS)

Acetic acid, tert-butyl ester

RTECS #

AF7400000

CAS #

540-88-5

Updated

September 201

Molecular Weight

116.18

Molecular Formula

C6H12O2

Synonyms

1,1-Dimethyl acetate
Acetic acid, 1,1-dimethylethyl ester (9CI)
t-Butyl acetate
tert-Butyl acetate
tert-Butyl acetate (ACGIH:OSHA)
Texaco lead appreciator
TLA

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 µL mildNTIS** OTS0573684-1
skin /rabbit 500 µL/24H mildNTIS** OTS0573684-1

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 22400 mg/kg (6-19D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system		BDERB* 80,374,2007

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): >2230 mg/m3/4HNTIS** OTS0573684-1
inhalation/rat Lowest published lethal concentration: 1000 mg/m3Lung, Thorax, or Respiration: Other changes

Blood: Hemorrhage		RTOPDW 40,168,2004
oral/rat lethal dose (50 percent kill): 4100 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea		NTIS** OTS0573684-1
oral/rat lethal dose (50 percent kill): 4500 mg/kgUSXXAM #6673157
skin/rabbit lethal dose (50 percent kill): >2 gm/kgGastrointestinal: Hypermotility, diarrhea

Kidney, Ureter, and Bladder: Other changes		NTIS** OTS0573684-1

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 22400 mg/kg/13D- intermittentLiver: Changes in liver weight

Endocrine: Changes in adrenal weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		BDERB* 80,374,2007

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 200 ppmDTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 200 ppm (950 mg/m3)DTLVS* 3,31,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 200 ppm (950 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 20 ppm (96 mg/m3);KZW 20 ppm (96 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 200 ppm (964 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 150 ppm (710 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 150 ppm (720 mg/m3), short term exposure limit 200 ppm (960 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 200 ppm (950 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 20 ppm (96 mg/m3), 2011
Occupational Exposure Limit-ICELANDtime-weighted average 150 ppm (700 mg/m3), NOV2011
Occupational Exposure Limit-INDIAtime-weighted average 200 ppm (950 mg/m3), JAN1993
Occupational Exposure Limit-KOREAtime-weighted average 200 ppm (950 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 200 ppm (950 mg/m3);short term exposure limit 250 ppm (1190 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 200 ppm (950 mg/m3), JAN2002
Occupational Exposure Limit-PERUtime-weighted average 200 ppm (950 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 900 mg/m3, MAC(short term exposure limit) 900 mg/m3, JAN1999
Occupational Exposure Limit-SWEDENtime-weighted average 100 ppm (500 mg/m3);short term exposure limit 150 ppm (700 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 20 ppm (96 mg/m3), KZG-week 80 ppm (384 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 950 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 200 ppm (950 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 200 ppm (966 mg/m3);short term exposure limit 250 ppm (1210 mg/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 200 ppm (950 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 200 ppm (950 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 200 ppm (950 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 200 ppm (950 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO t-BUTYL ACETATE-air10H time-weighted average 200 ppmNIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Esters I, 1450

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