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Registry of Toxic Effects of Chemical Substances (RTECS)

Acetic acid, isobutyl ester

RTECS #

AI4025000

CAS #

110-19-0

Updated

September 201

Molecular Weight

116.18

Molecular Formula

C6H12O2

Synonyms

2-Methyl-1-propyl acetate
2-Methylpropyl acetate
Acetate d'isobutyle (French)
Acetic acid, 2-methylpropyl ester
beta-Methylpropyl ethanoate
Isobutyl acetate
Isobutyl acetate (ACGIH:OSHA)
Isobutylester kyseliny octove (Czech)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg/24H moderateFCTXAV 16,795,1978
skin /rabbit 500 mg open irritation test mildUCDS** 11/3/1971
skin /rabbit 500 mg/24H moderateFCTXAV 16,795,1978

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lowest published lethal concentration: 8000 ppm/4HAIHAAP 23,95,1962
oral/rabbit lethal dose (50 percent kill): 4763 mg/kgIMSUAI 41,31,1972
oral/rat lethal dose (50 percent kill): 13400 mg/kgNPIRI* 1,8,1974
skin/rabbit lethal dose (50 percent kill): >17400 mg/kgNPIRI* 1,8,1974

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 150 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWHUTOX* -,649,1996

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 150 ppm (700 mg/m3)DTLVS* 3,139,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 150 ppm (713 mg/m3), JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 150 ppm (723 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 150 ppm (710 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 150 ppm (720 mg/m3), short term exposure limit 200 ppm (960 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 150 ppm (710 mg/m3), VLE 200 ppm (940 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 100 ppm (480 mg/m3), 2011
Occupational Exposure Limit-ICELANDtime-weighted average 150 ppm (700 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 150 ppm (700 mg/m3), short term exposure limit 187 ppm (875 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 150 ppm (700 mg/m3);short term exposure limit 187 ppm (875 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 150 ppm (713 mg/m3), JAN2002
Occupational Exposure Limit-PERUtime-weighted average 150 ppm (713 mg/m3), JUL2005
Occupational Exposure Limit-SWEDENtime-weighted average 100 ppm (500 mg/m3);short term exposure limit 150 ppm (700 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 100 ppm (480 mg/m3), KZG-week 200 ppm (960 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 700 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 150 ppm (700 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 150 ppm (724 mg/m3);short term exposure limit 187 ppm (903 mg/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 150 ppm (700 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 150 ppm (700 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 150 ppm (700 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 150 ppm (700 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ISOBUTYL ACETATE-air10H time-weighted average 150 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 40410; Number of Industries 113; Total Number of Facilities 11899; Number of Occupations 78; Total Number of Employees Exposed 160286; Total Number of Female Employees Exposed 41243
National Occupational Hazard Survey 1974Hazard Code 40410; Number of Industries 150; Total Number of Facilities 16707; Number of Occupations 81; Total Number of Employees Exposed 85472

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Esters I, 1450

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