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Registry of Toxic Effects of Chemical Substances (RTECS)

Acetic acid, isopropyl ester

RTECS #

AI4930000

CAS #

108-21-4

Updated

September 201

Molecular Weight

102.15

Molecular Formula

C5H10O2

Synonyms

2-Acetoxypropane
2-Propyl acetate
Acetate d'isopropyle (French)
Acetic acid, 1-methylethyl ester (9CI)
Isopropile (acetato di) (Italian)
Isopropyl (acetate d') (French)
Isopropyl acetate
Isopropyl acetate (ACGIH:OSHA)
Isopropylacetaat (Dutch)
Isopropylacetat (German)
Isopropylester kyseliny octove (Czech)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /human 200 ppm/15MJIHTAB 28,262,1946
skin /rabbit 500 mg/24H mild85JCAE -,354,1986

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 200 ppmLung, Thorax, or Respiration: Other changesAMIHAB 21,28,1960
inhalation/rat lethal concentration (50 percent kill): 50600 mg/m3/8HAIHAAP 20,364,1959
intraperitoneal/rat Lethal dose: >174 mg/kgJSGRA2 53,572,1992
intravenous/rat lowest published lethal dose: 174 mg/kgJSGRA2 53,572,1992
oral/rabbit lethal dose (50 percent kill): 6946 mg/kgIMSUAI 41,31,1972
oral/rat lethal dose (50 percent kill): 6750 mg/kgUCDS** 3/24/1970
skin/rabbit lethal dose (50 percent kill): >20 mL/kgAMIHBC 10,61,1954
unreported route/human lowest published toxic concentration: 200 ppmEye: Conjunctiva irritationJIHTAB 28,262,1946

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 100 ppm;short term exposure limit 200 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWAMIHAB 21,28,1960
TOXICOLOGY REVIEWHUTOX* -,649,1996

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 250 ppm (950 mg/m3)DTLVS* 3,141,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 250 ppm (1040 mg/m3), short term exposure limit 310 ppm (1290 mg/m3), JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 100 ppm(424 mg/m3), short term exposure limit 200 ppm(849 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 150 ppm (625 mg/m3), MAY2011
Occupational Exposure Limit-FRANCEVME 250 ppm (950 mg/m3), VLE 300 ppm (1140 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 100 ppm (420 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 840 mg/m3, short term exposure limit 840 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 150 ppm (625 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 250 ppm (950 mg/m3), short term exposure limit 310 ppm (1185 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 250 ppm (950 mg/m3);short term exposure limit 310 ppm (1185 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 250 ppm (1040 mg/m3); short term exposure limit 310 ppm (1290 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 100 ppm (240 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 100 ppm (418 mg/m3); short term exposure limit 200 ppm (835 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAtime-weighted average 50 mg/m3, short term exposure limit 200 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 100 ppm (420 mg/m3), KZG-week 200 ppm (840 mg/m3), JAN2011
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 250 ppm (950 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMshort term exposure limit 200 ppm (849 mg/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 250 ppm (950 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 250 ppm (950 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 250 ppm (950 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 250 ppm (950 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 40984; Number of Industries 85; Total Number of Facilities 8643; Number of Occupations 68; Total Number of Employees Exposed 159819; Total Number of Female Employees Exposed 50913
National Occupational Hazard Survey 1974Hazard Code 40984; Number of Industries 103; Total Number of Facilities 10160; Number of Occupations 67; Total Number of Employees Exposed 84001

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Isopropyl acetate, 1454

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