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Registry of Toxic Effects of Chemical Substances (RTECS)

Acetic acid, mercapto-

RTECS #

AI5950000

CAS #

68-11-1

Updated

September 201

Molecular Weight

92.12

Molecular Formula

C2H4O2S

Synonyms

2-Mercaptoacetic acid
2-Thioglycolic acid
Acide thioglycolique (French)
alpha-Mercaptoacetic acid
Glycolic acid, 2-thio-
Glycolic acid, thio-
Kyselina merkaptooctova (Czech)
Kyselina thioglykolova (Czech)
Mercaptoacetate
Mercaptoacetic acid
Thioglycolic acid
Thioglycolic acid (ACGIH)
Thioglycollic acid
Thiovanic acid
USAF CB-35

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /human 3%INMEAF 15,669,1946

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 8.3 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
inhalation/mouse Lowest published lethal concentration: 7 mg/m3/2H85GMAT -,111,1982
inhalation/rat lethal concentration (50 percent kill): 210 mg/m3/4HBehavioral: Food intake (animal)

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Changes in lung weight		NTIS** OTS0554077
intraperitoneal/guinea pig lethal dose (50 percent kill): 157 mg/kgZHYGAM 20,575,1974
intraperitoneal/mouse lethal dose (50 percent kill): 138 mg/kgARZNAD 31,1713,1981
intraperitoneal/rat lethal dose (50 percent kill): 70 mg/kgZHYGAM 20,575,1974
intravenous/mouse lethal dose (50 percent kill): 145 mg/kgNYKZAU 60,278,1964
intravenous/rabbit lethal dose (50 percent kill): 100 mg/kgBIJOAK 41,325,1947
oral/guinea pig lethal dose (50 percent kill): 126 mg/kg34ZIAG -,586,1969
oral/mammal (species unspecified) lethal dose (50 percent kill): 250 mg/kgGISAAA 39(4),86,1974
oral/mouse lethal dose (50 percent kill): 242 mg/kgZHYGAM 20,575,1974
oral/rabbit lethal dose (50 percent kill): 119 mg/kgZHYGAM 20,575,1974
oral/rat lethal dose (50 percent kill): 114 mg/kgZHYGAM 20,575,1974
skin/mouse lethal dose (50 percent kill): 47 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold		SRTCAC 36(1-4),10,1989
skin/rabbit lowest published lethal dose: 300 mg/kgSkin: After systemic exposure: Dermatitis, otherGTPZAB 13(1),48,1969

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
subcutaneous/guinea pig lowest published toxic dose: 210 mg/kg/14D- intermittentBrain and Coverings: Other degenerative changes

Behavioral: Change in psychophysiological tests		TXAPA9 177,103,2001
subcutaneous/guinea pig lowest published toxic dose: 105 mg/kg/7D- intermittentBehavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)		TXAPA9 177,103,2001

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 1 ppm (skin)DTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1 ppm (3.8 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 1 ppm (4 mg/m3);KZW 2 ppm (8 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 1 ppm (3.9 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 1 ppm (5 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 1 ppm (3.8 mg/m3), short term exposure limit 3 ppm (11 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 1 ppm (5 mg/m3), Skin, FEB2006
Occupational Exposure Limit-HUNGARYtime-weighted average 4 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 1 ppm (5 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 1 ppm (4 mg/m3), skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 1 ppm (5 mg/m3) (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 1 ppm (3.8 mg/m3), skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 1 ppm (5 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 1 ppm (3.8 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.1 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 1 ppm (4 mg/m3);short term exposure limit 2 ppm (8 mg/m3), Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 1 ppm (4 mg/m3), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 4 mg/m3, Skin, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 1 ppm (3.8 mg/m3), OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THIOGLYCOLIC ACID-air10H time-weighted average 1 ppm (Sk)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 83835; Number of Industries 10; Total Number of Facilities 2428; Number of Occupations 12; Total Number of Employees Exposed 30055; Total Number of Female Employees Exposed 15141
National Occupational Hazard Survey 1974Hazard Code 83835; Number of Industries 10; Total Number of Facilities 5167; Number of Occupations 9; Total Number of Employees Exposed 35238

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

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