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Registry of Toxic Effects of Chemical Substances (RTECS)

Acetic acid, (2,4,5-trichlorophenoxy)-

RTECS #

AJ8400000

CAS #

93-76-5

Updated

September 201

Molecular Weight

255.48

Molecular Formula

C8H5Cl3O3

Synonyms

(2,4,5-Trichloor-fenoxy)-azijnzuur (Dutch)
(2,4,5-Trichlor-phenoxy)-essigsaeure (German)
2,4,5-T
2,4,5-T (ACGIH:OSHA)
2,4,5-Trichlorophenoxyacetic acid (OSHA)
Acide 2,4,5-trichloro phenoxyacetique (French)
Acido (2,4,5-tricloro-fenossi)-acetico (Italian)
Arbokan
BCF-Bushkiller
Brush RHAP
Brush-off 445 low volatile brush killer
Brushtox
Dacamine
Debroussaillant concentre
Debroussaillant super concentre
Ded-weed brush killer
Ded-weed LV-6 brush kil and T-5 brush kil
Envert-T
Estercide T-2 and T-245
Farmco fence rider
Fence rider
Fortex
Fruitone A
Inverton 245
Kwas 2,4,5-trojchlorofenoksyoctowy (Polish)
Line rider
Phortox
RCRA waste number U232
Tippon
Verton 2T
Visko rhap low volatile ester

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisoral/Drosophila melanogaster250 ppmMUREAV 65,83,1979
Cytogenetic Analysisovary/hamster1750 mg/LEMMUEG 10(Suppl 10),1,1987
Cytogenetic Analysisintraperitoneal/mammal (species unspecified)250 mg/kg/5D- intermittentJOHEA8 64,213,1973
Cytogenetic Analysisintraperitoneal/gerbil250 mg/kgMUREAV 65,83,1979
Cytogenetic Analysisparenteral/gerbil250 mg/kgECBUDQ 27,182,1978
Cytogenetic Analysisintraperitoneal/mouse4 mg/kgARTODN 74,560,2000
DNA Damagelymphocyte/mammal (species unspecified)100 µmol/LPYTCAS 11,3135,1972
DNA Damagesperm/salmon100 µmol/LPYTCAS 11,3135,1972
mutation in microorganisms/Saccharomyes cerevisiae35 mg/L (-enzymatic activation step)ECBUDQ 27,193,1978
mutation in microorganisms/Bacillus subtilis1 nmol/plate (-enzymatic activation step)MSERDS 5,93,1981
sex chromosome loss and nondisjunctionoral/Drosophila melanogaster1000 ppm/15DMUREAV 65,83,1979
sex chromosome loss and nondisjunctionunreported route/Drosophila melanogaster1000 ppm/15DECBUDQ 27,182,1978
sister chromatid exchangeovary/hamster300 mg/LEMMUEG 10(Suppl 10),1,1987
specific locus testmultiple/Drosophila melanogaster10 ppbEMMUEG 25,148,1995
specific locus test/Drosophila melanogaster10 mmol/LEMMUEG 36,40,2000

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/hamster 200 mg/kg (7-11D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)		BECTA6 6,559,1971
oral/hamster 500 mg/kg (7-11D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Musculoskeletal system		BECTA6 6,559,1971
oral/rat 100 mg/kg (8D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)PHBHA4 9,357,1972
oral/rat 6 mg/kg (8D pregnant)Reproductive: Effects on newborn: BehavioralEXPEAM 39,891,1983
oral/rat 714 mg/kg (multigenerations)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)		FCTXAV 19,41,1981
oral/rat 27600 µg/kg (10-15D pregnant)Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Other developmental abnormalities		EVSRBT 2,708,1973
oral/rat 100 mg/kg (11D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathBEXBAN 76,831,1973
oral/rat 500 mg/kg (6-10D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)TJADAB 4,243,1971
oral/mouse 200 mg/kg (6-15D pregnant)Reproductive: Effects on newborn: StillbirthTJADAB 23,33,1981
oral/mouse 6250 µg/kg (10D male)Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Reproductive: Other effects on male		TXAPA9 25,441,1973
oral/mouse 300 mg/kg (12D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)NSAPCC 272,243,1972
oral/mouse 900 mg/kg (6-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)NSAPCC 272,243,1972
oral/mouse 150 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)NSAPCC 272,243,1972
oral/mouse 1 gm/kg (8-12D pregnant)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)		TCMUD8 6,361,1986
subcutaneous/mouse 1 gm/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other effects on female

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		TXAPA9 20,396,1971
subcutaneous/mouse 1 gm/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Urogenital system		TXAPA9 20,396,1971
subcutaneous/mouse 1 gm/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)TXAPA9 22,317,1972
subcutaneous/mouse 450 mg/kg (6-14D pregnant)Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)		APTOA6 32,408,1973
subcutaneous/rat 300 mg/kg (13-14D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathTXAPA9 20,396,1971
unreported route/rat 27600 µg/kg (10-15D pregnant)Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Gastrointestinal system

Reproductive: Specific developmental abnormalities: Urogenital system		NTIS** PB223-160
unreported route/rat 278 mg/kg (10-15D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)NTIS** PB223-160
unreported route/rat 60 mg/kg (10-15D pregnant)Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)NTIS** PB223-160

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 3379 mg/kg/33W- continuousTumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors

Skin and Appendages: Tumors		BJCAAI 33,626,1976
subcutaneous/mouse lowest published toxic dose: 215 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Tumors		NTIS** PB223-159

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Mouse, embryo Inhibitor Concentration Low: 0.88 mmol/L/48HReproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear		TIVIEQ 4,771,1990
In Vitro/Rat, embryo Inhibitor Concentration Low: 1.76 mmol/L/48HReproductive: Effects on embryo or fetus: Fetal deathTIVIEQ 4,771,1990
In Vitro/Rat, embryo Inhibitor Concentration Low: 3.52 mmol/L/48HReproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear		TIVIEQ 4,771,1990
oral/chicken lethal dose (50 percent kill): 310 mg/kgGastrointestinal: Gastritis

Behavioral: Somnolence (general depressed activity)

Liver: Fatty liver degeneration		AJVRAH 15,622,1954
oral/Dog lethal dose (50 percent kill): 100 mg/kgPAREAQ 14,225,1962
oral/guinea pig lethal dose (50 percent kill): 381 mg/kgPCOC** -,1178,1966
oral/hamster lethal dose (50 percent kill): 425 mg/kgMUREAV 65,83,1979
oral/mammal (species unspecified) lethal dose (50 percent kill): 500 mg/kgSCIEAS 165,465,1969
oral/mouse lethal dose (50 percent kill): 242 mg/kgRPZHAW 31,373,1980
oral/rat lethal dose (50 percent kill): 300 mg/kgRREVAH 10,97,1965
skin/rat lethal dose (50 percent kill): 1535 mg/kgFAATDF 7,299,1986
unreported route/rat lethal dose (50 percent kill): 500 mg/kg30ZDA9 -,171,1971

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published toxic dose: 700 mg/kg/90D- intermittentBlood: Changes in other cell count (unspecified)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		AMIHBC 7,61,1953
oral/mammal (species unspecified) lowest published toxic dose: 78480 mg/kg/30D- continuousBehavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		NTIS** PB288-416
oral/mouse lowest published toxic dose: 450 mg/kg/3D- intermittentLiver: Other changes

Liver: Changes in liver weight		TXCYAC 249,176,2008
oral/rat lowest published toxic dose: 196 mg/kg/28W- intermittentLiver: Fatty liver degenerationGTPZAB 30(7),48,1986

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 10 mg/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Human Limited EvidenceIMEMDT 41,357,1986
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 15,273,1977
TOXICOLOGY REVIEWRREVAH 59,1,1975
TOXICOLOGY REVIEWARPAAQ 94,125,1972
TOXICOLOGY REVIEWDTTIAF 80,485,1973
TOXICOLOGY REVIEWRREVAH 56,107,1975
TOXICOLOGY REVIEWECMAAI 14,141,1973
TOXICOLOGY REVIEWBIOGAL 40(2),44,1974
TOXICOLOGY REVIEWSTEVA8 2,305,1974
TOXICOLOGY REVIEWEVSRBT 2,708,1973
TOXICOLOGY REVIEWVHTODE 22,31,1980
TOXICOLOGY REVIEWJTCTDW 38,111,2000
TOXICOLOGY REVIEWCRTXB2 33,137,2003
TOXICOLOGY REVIEWENTOX* -,569,2005
TOXICOLOGY REVIEWJTEHD6 7,1,2004
TOXICOLOGY REVIEWHUTOX* -,551,1996
TOXICOLOGY REVIEWMUREAV 543,251,2003
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 10 mg/m3DTLVS* 3,242,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 10 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 10 mg/m3;KZW 50 mg/m3, inhal, skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 10 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 5 mg/m3, skin, MAY2011
Occupational Exposure Limit-FRANCEVME 10 mg/m3, FEB2006
Occupational Exposure Limit-GERMANYMAK 2 mg/m3, inhal, skin, 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 10 mg/m3, short term exposure limit 40 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 5 mg/m3, skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 10 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 10 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 10 mg/m3, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 10 mg/m3, JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 10 mg/m3, KZG-week 20 mg/m3, inhal, skin, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 10 mg/m3, JAN1993
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 10 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 10 mg/m3, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 10 mg/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 10 mg/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 10 mg/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 10 mg/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 2,4,5-T-air10H time-weighted average 10 mg/m3NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974Hazard Code 73900; Number of Industries 2; Total Number of Facilities 177; Number of Occupations 3; Total Number of Employees Exposed 1560

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: Host-mediated assay; Mammalian micronucleus
EPA GENETOX PROGRAM 1988, Negative: D melanogaster-nondisjunction
EPA GENETOX PROGRAM 1988, Negative: D melanogaster-whole sex chrom. loss
EPA GENETOX PROGRAM 1988, Positive/dose response: In vivo cytogenetics-nonhuman bone marrow
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal; S cerevisiae-reversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: 2,4,5-T, 5001
On EPA IRIS database

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