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Registry of Toxic Effects of Chemical Substances (RTECS)

Acetylene, dichloro-

RTECS #

AP1080000

CAS #

7572-29-4

Updated

September 201

Molecular Weight

94.92

Molecular Formula

C2Cl2

Synonyms

Dichloroacetylene
Dichloroacetylene (ACGIH:OSHA)
Dichloroethyne
Ethyne, dichloro- (9CI)

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium4000 ppm (+/-enzymatic activation step)MUREAV 117,21,1983

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 2 ppm/24H/77W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors

Blood: Tumors		CRNGDP 5,1411,1984
inhalation/rat lowest published toxic concentration: 14 ppm/6H/77W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Vascular: Tumors

Kidney, Ureter, and Bladder: Kidney tumors		CRNGDP 5,1411,1984

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 19 ppm/6HBehavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Dyspnea

Skin and Appendages: Other: Hair		FCTXAV 13,511,1975
inhalation/mouse lethal concentration (50 percent kill): 480 mg/m3/1HVCVGH* -,530,1990
inhalation/mouse lethal concentration (50 percent kill): 74 mg/m3/6HBrain and Coverings: Other degenerative changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)		VCVGH* -,530,1990
inhalation/rabbit Lowest published lethal concentration: 307 ppm/1HLiver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)		FCTXAV 16,227,1978

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intramuscular/rat lowest published toxic dose: 850 mg/kg/10W- intermittentPeripheral Nerve and Sensation: Structural change in nerve or sheath

Biochemical: Metabolism (intermediary): Lipids including transport		NRTXDN 13,601,1992

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-ceiling concentration 0.1 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 39,369,1986
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 71,1381,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 39,369,1986
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 71,1381,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 71,1381,1999
TOXICOLOGY REVIEWARPTDI 45,147,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWNEUCL* 18,741,2000

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARDair-ceiling concentration 0.1 ppm (0.4 mg/m3)DTLVS* 3,75,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAceiling concentration 0.1 ppm (0.39 mg/m3), Carcinogen, JUL2008
Occupational Exposure Limit-BELGIUMshort term exposure limit 0.1 ppm (0.4 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKceiling concentration 0.1 ppm (0.4 mg/m3), carc, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.1 ppm (0.39 mg/m3), short term exposure limit 0.3 ppm (1.2 mg/m3), NOV2011
Occupational Exposure Limit-ICELANDshort term exposure limit 0.1 ppm (0.4 mg/m3), NOV2011
Occupational Exposure Limit-KOREAceiling concentration 0.1 ppm (0.4 mg/m3), 2006
Occupational Exposure Limit-MEXICOpeak 0.1 ppm (0.4 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDceiling concentration 0.1 ppm (0.39 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.1 ppm (0.4 mg/m3), JAN1999
Occupational Exposure Limit-PERUshort term exposure limit 0.1 ppm (0.39 mg/m3), JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 ppm (0.4 mg/m3), carc 2, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-C 0.4 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMshort term exposure limit 0.1 ppm (0.39 mg/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)ceiling concentration 0.1 ppm (0.4 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)ceiling concentration 0.1 ppm (0.4 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DICHLOROACETYLENE-airCarcinogen ceiling concentration 0.1 ppmNIOSH* DHHS #95-121,1995
National Occupational Exposure Survey 1983Hazard Code X5342; Number of Industries 1; Total Number of Facilities 3; Number of Occupations 3; Total Number of Employees Exposed 61; Total Number of Female Employees Exposed 6

Status in Federal Agencies

OrganizationReference
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

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