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Registry of Toxic Effects of Chemical Substances (RTECS)

Acrylic acid, 2-cyano-, methyl ester

RTECS #

AS7000000

CAS #

137-05-3

Updated

September 201

Molecular Weight

111.11

Molecular Formula

C5H5NO2

Synonyms

2-Cyanoacrylic acid, methyl ester
Adhere
alpha-Cyanoacrylic acid methyl ester
Coapt
Cyanolit
Eastman 910
Eastman 910 adhesive
Eastman 910 monomer
Mecrilat
Mecrylate
Methyl 2-cyanoacrylate
Methyl 2-cyanoacrylate (ACGIH)
Methyl alpha-cyanoacrylate
Methyl cyanoacrylate

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /human 4 ppmAIHAAP 29,558,1968
skin /rabbit 500 µg/4H severeIJTOFN 16(Suppl 2),40,1997

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium100 µg/plate (+enzymatic activation step)ENMUDM 9(Suppl 9),1,1987
mutation in microorganisms/Salmonella typhimurium300 µg/plate (-enzymatic activation step)MUREAV 188,97,1987

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intratesticular/monkey 100 mg/kg (1D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)FESTAS 39(Suppl),441,1983

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 101 ppm/6H85INA8 6,965,1991
oral/rat lethal dose (50 percent kill): 1600 mg/kg85INA8 6,965,1991
skin/guinea pig lethal dose (50 percent kill): >10959 mg/kg85INA8 6,965,1991

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 31300 ppb/6H/12D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTIS** OTS0518526-1

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.2 ppmDTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 2 ppm (8 mg/m3)DTLVS* 3,162,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 2 ppm (9.1 mg/m3), short term exposure limit 4 ppm (18 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 2 ppm (8 mg/m3), sen, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 2 ppm (9.2 mg/m3), short term exposure limit 4 ppm (18 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 2 ppm (8 mg/m3), MAY2011
Occupational Exposure Limit-FRANCEVME 2 ppm (8 mg/m3), VLE 4 ppm (18 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 2 ppm (9,2 mg/m3), 2011
Occupational Exposure Limit-ICELANDtime-weighted average 2 ppm (9 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 2 ppm (8 mg/m3), short term exposure limit 4 ppm (16 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 2 ppm (8 mg/m3);short term exposure limit 4 ppm (16 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 2 ppm (9.1 mg/m3); short term exposure limit 4 ppm (18 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 2 ppm (8 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0.2 ppm (0.91 mg/m3), JUL2005
Occupational Exposure Limit-SWEDENtime-weighted average 2 ppm (9 mg/m3);short term exposure limit 4 ppm (18 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 2 ppm (9 mg/m3), JAN2011
Occupational Exposure Limit-UNITED KINGDOMshort term exposure limit 0.3 ppm (1.4 mg/m3), OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL 2-CYANOACRYLATE-air10H time-weighted average 2 ppm;short term exposure limit 4 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code M4755; Number of Industries 46; Total Number of Facilities 1434; Number of Occupations 51; Total Number of Employees Exposed 51367; Total Number of Female Employees Exposed 22918
National Occupational Hazard Survey 1974Hazard Code M4755; Number of Industries 25; Total Number of Facilities 895; Number of Occupations 25; Total Number of Employees Exposed 18406

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #ID-55

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