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Registry of Toxic Effects of Chemical Substances (RTECS)

Aniline, N,N-dimethyl-

RTECS #

BX4725000

CAS #

121-69-7; 162744-63-0; 168153-21-7; 171745-67-8

Updated

September 201

Molecular Weight

121.20

Molecular Formula

C8H11N

Synonyms

(Dimethylamino)benzene
Benzenamine, N,N-dimethyl-
Dimethylaniline
Dimethylaniline (ACGIH:OSHA)
Dwumetyloanilina (Polish)
N,N-Dimethylaniline
N,N-Dimethylaniline (OSHA)
N,N-Dimethylbenzenamine
N,N-Dimethylphenylamine
NCI-C56428
NL 63-10P
Versneller NL 63/10

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 20 mg/24H moderate85JCAE -,461,1986
eye /rabbit 20 mg moderateHPV300 -,-,2001
skin /rabbit 500 mg mildHPV300 -,-,2001
skin /rabbit 10 mg/24H open irritation test mildAIHAAP 23,95,1962
skin /rabbit 500 mg/24H mild85JCAE -,461,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster83 mg/LEMMUEG 13,60,1989
DNA Damageintraperitoneal/rat485 mg/kgEMMUEG 21,349,1993
DNA Damageintraperitoneal/mouse242 mg/kgHPV300 -,-,2001
micronucleus testlung/hamster900 µmol/LEMMUEG 21,349,1993
micronucleus testovary/hamster140 mg/L (-enzymatic activation step)HPV300 -,-,2001
mutation in mammalian somatic cellslymphocyte/mouse20 mg/LNTPTR* NTP-TR-360,1989
sister chromatid exchangeovary/hamster30 mg/LEMMUEG 13,60,1989

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/mouse 2920 mg/kg (7-14D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)		HPV300 -,-,2001

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 15450 mg/kg/2Y- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Tumors		NTPTR* NTP-TR-360,1989
oral/mouse lowest published toxic dose: 15450 mg/kg/103W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors		NTIS** PB90-227240/AS
oral/mouse lowest published toxic dose: 15450 mg/kg/103W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains		HPV300 -,-,2001
oral/rat lowest published toxic dose: 15450 mg/kg/2Y- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Tumors		NTPTR* NTP-TR-360,1989
oral/rat lowest published toxic dose: 1545 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia

Tumorigenic: Increased incidence of tumors in susceptible strains		HPV300 -,-,2001
oral/rat lowest published toxic dose: 15450 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Blood: Tumors		NTIS** PB90-227240/AS

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig Lowest published lethal concentration: 980 mg/m3/30MHPV300 -,-,2001
inhalation/rat Lowest published lethal concentration: 250 mg/m3/4HBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement		GISAAA 37(4),35,1972
inhalation/rat Lowest published lethal concentration: 250 mg/m3/4HHPV300 -,-,2001
inhalation/rat Lowest published lethal concentration: 980 mg/m3/30MHPV300 -,-,2001
intraperitoneal/mouse lethal dose (50 percent kill): 960 mg/kgHPV300 -,-,2001
intraperitoneal/mouse lowest published toxic dose: 60 mg/kgBlood: Methemoglobinemia- CarboxhemoglobinemiaHPV300 -,-,2001
intraperitoneal/rat lowest published toxic dose: 39 mg/kgBlood: Methemoglobinemia- CarboxhemoglobinemiaHPV300 -,-,2001
oral/cat lowest published toxic dose: 50 mg/kgBlood: Methemoglobinemia- CarboxhemoglobinemiaHPV300 -,-,2001
oral/Dog lowest published toxic dose: 50 mg/kgBlood: Methemoglobinemia- CarboxhemoglobinemiaHPV300 -,-,2001
oral/guinea pig lowest published lethal dose: 2000 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression		HPV300 -,-,2001
oral/human lowest published lethal dose: 50 mg/kgHPV300 -,-,2001
oral/human lowest published lethal dose: 50 mg/kgGastrointestinal: Nausea or vomiting

Gastrointestinal: Other changes		NCPBBY Jan/Feb,1969
oral/mouse lethal dose (50 percent kill): 1440 mg/kgHPV300 -,-,2001
oral/mouse lowest published lethal dose: 350 mg/kgHPV300 -,-,2001
oral/rat lethal dose (50 percent kill): 951 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Lung, Thorax, or Respiration: Cyanosis		NTIS** OTS0571982
oral/rat lethal dose (50 percent kill): 1120 mg/kgHPV300 -,-,2001
skin/guinea pig lethal dose (50 percent kill): >20 mL/kgSkin: After systemic exposure: Dermatitis, otherNTIS** OTS0571982
skin/rabbit lethal dose (50 percent kill): 1770 µL/kgAIHAAP 23,95,1962
skin/rabbit lethal dose (50 percent kill): 1770 mg/kgHPV300 -,-,2001
subcutaneous/guinea pig lowest published lethal dose: 2000 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression		HPV300 -,-,2001
subcutaneous/rat lowest published lethal dose: 100 mg/kg85GMAT -,55,1982
subcutaneous/rat lowest published lethal dose: 100 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression		HPV300 -,-,2001

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 10700 µg/m3/5H/17W- intermittentBlood: Pigmented or nucleated red blood cells

Blood: Methemoglobinemia- Carboxhemoglobinemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases		GISAAA 37(4),35,1972
inhalation/rat lowest published toxic concentration: 300 µg/m3/24H/14W- continuousBehavioral: Muscle contraction or spasticity

Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in erythrocyte (RBC) count		GISAAA 34(3),7,1969
inhalation/rat lowest published toxic concentration: 0.3 mg/m3/100D- continuousBlood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count		HPV300 -,-,2001
oral/mouse lowest published toxic dose: 2812.5 mg/kg/15D- intermittentEndocrine: Changes in spleen weightHPV300 -,-,2001
oral/mouse lowest published toxic dose: 9000 mg/kg/12D- intermittentBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands		HPV300 -,-,2001
oral/mouse lowest published toxic dose: 4500 mg/kg/3D- intermittentBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands		HPV300 -,-,2001
oral/mouse lowest published toxic dose: 4062.5 mg/kg/13W- intermittentEndocrine: Changes in spleen weight

Blood: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		HPV300 -,-,2001
oral/mouse lowest published toxic dose: 2920 mg/kg/8D- intermittentBehavioral: Tremor

Behavioral: Ataxia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		HPV300 -,-,2001
oral/mouse lowest published toxic dose: 32500 mg/kg/13W- intermittentBlood: Changes in spleenJTEHD6 29,77,1990
oral/mouse lowest published toxic dose: 32500 mg/kg/13W- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen		NTPTR* NTP-TR-360,1989
oral/rat lowest published toxic dose: 1545 mg/kg/103W- intermittentBlood: Leukemia

Tumorigenic: Active as anti-cancer agent		NTIS** PB90-227240/AS
oral/rat lowest published toxic dose: 2 gm/kg/2D- intermittentBehavioral: Food intake (animal)

Behavioral: Ataxia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		NTIS** OTS0571982
oral/rat lowest published toxic dose: 1100 mg/kg/15D- intermittentEndocrine: Changes in spleen weightNTIS** OTS0571982
oral/rat lowest published toxic dose: 1312.5 mg/kg/14D- intermittentEndocrine: Changes in spleen weightHPV300 -,-,2001
oral/rat lowest published toxic dose: 4500 mg/kg/6D- intermittentEndocrine: Changes in spleen weight

Blood: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		HPV300 -,-,2001
oral/rat lowest published toxic dose: 4500 mg/kg/3D- intermittentEndocrine: Changes in spleen weight

Blood: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		HPV300 -,-,2001
oral/rat lowest published toxic dose: 2031.25 mg/kg/13W- intermittentEndocrine: Changes in spleen weight

Blood: Changes in bone marrow not included in above

Blood: Changes in spleen		HPV300 -,-,2001
oral/rat lowest published toxic dose: 32500 mg/kg/13W- intermittentKidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		JTEHD6 29,77,1990
oral/rat lowest published toxic dose: 16250 mg/kg/13W- intermittentLiver: Other changes

Blood: Changes in bone marrow not included in above

Blood: Changes in spleen		NTPTR* NTP-TR-360,1989
subcutaneous/Dog lowest published toxic dose: 0.2 gm/kg/3D- intermittentBehavioral: Food intake (animal)

Gastrointestinal: Changes in structure or function of salivary glands

Blood: Methemoglobinemia- Carboxhemoglobinemia		HPV300 -,-,2001
subcutaneous/guinea pig lowest published toxic dose: 436.8 mg/kg/389D- intermittentLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder		HPV300 -,-,2001
subcutaneous/rat lowest published toxic dose: 1 gm/kg/10D- intermittentBlood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects		HPV300 -,-,2001

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 5 ppm;short term exposure limit 10 ppm (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 57,337,1993
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 57,337,1993
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 57,337,1993
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUTAEX 23,271,2008
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 5 ppm (25 mg/m3), short term exposure limit 10 ppm (50 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 5 ppm (25 mg/m3);KZW 20 ppm (100 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 5 ppm (25 mg/m3), MAR2002
Occupational Exposure Limit-BELGIUMshort term exposure limit 10 ppm (51 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 5 ppm (25 mg/m3), skin, carc, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 5 ppm (25 mg/m3), short term exposure limit 10 ppm (50 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 5 ppm (25 mg/m3), Skin, C3 Carcinogen, FEB2006
Occupational Exposure Limit-GERMANYMAK 5 ppm (25 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 25 mg/m3, short term exposure limit 100 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 5 ppm (25 mg/m3), skin, NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 5 ppm (25 mg/m3), skin, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 5 ppm (25 mg/m3), short term exposure limit 10 ppm (50 mg/m3), skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 5 ppm (25 mg/m3);short term exposure limit 10 ppm (50 mg/m3) (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 5 ppm (25 mg/m3); short term exposure limit 10 ppm (50 mg/m3), skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 5 ppm (25 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 5 ppm (25 mg/m3); short term exposure limit 10 ppm (50 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 5 mg/m3, MAC(short term exposure limit) 40 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.2 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 1 ppm (5 mg/m3);short term exposure limit 2 ppm (10 mg/m3), Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 5 ppm (25 mg/m3), KZG-week 10 ppm (50 mg/m3), carc 3, skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 5 mg/m3, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 5 ppm (25 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 5 ppm (25 mg/m3);short term exposure limit 10 ppm (50 mg/m3), skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 5 ppm (25 mg/m3) (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 5 ppm (25 mg/m3) (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 5 ppm (25 mg/m3) (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 5 ppm (25 mg/m3) (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIMETHYLANILINE-air10H time-weighted average 5 ppm (Sk);short term exposure limit 10 ppm (Sk)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 26335; Number of Industries 15; Total Number of Facilities 1428; Number of Occupations 27; Total Number of Employees Exposed 30480; Total Number of Female Employees Exposed 7448
National Occupational Hazard Survey 1974Hazard Code 26335; Number of Industries 4; Total Number of Facilities 100; Number of Occupations 10; Total Number of Employees Exposed 2456

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);equivocal evidence:mouse,rat
NIOSH Analytical Method, 1994: Amines, aromatic, 2002
NTP Carcinogenesis Studies (gavage);some evidence:rat NTPTR* NTP-TR-360,1989
On EPA IRIS database

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