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Registry of Toxic Effects of Chemical Substances (RTECS)

Aniline, N-methyl-N,2,4,6-tetranitro-

RTECS #

BY6300000

CAS #

479-45-8

Updated

September 201

Molecular Weight

287.17

Molecular Formula

C7H5N5O8

Synonyms

2,4,6-Tetryl
2,4,6-Trinitrophenylmethylnitramine
2,4,6-Trinitrophenylmethylnitramine (OSHA)
2,4,6-Trinitrophenyl-N-methylnitramine
Benzenamine, N-methyl-N,2,4,6-tetranitro- (9CI)
CE
Nitramine
Nitramine (indicator)
N-Methyl-N,2,4,6-tetranitroaniline
N-Methyl-N,2,4,6-tetranitrobenzenamine
N-Methyl-N-2,4,6-tetranitroaniline
Picrylmethylnitramine
Picrylnitromethylamine
Tetralit
Tetralite
Tetril
Tetryl
Tetryl (ACGIH:OSHA)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg severeATDAEI 1,167,1992

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
gene conversion and mitotic recombination/Saccharomyes cerevisiae5 µg/plateTOLED5 5,11,1980
mutation in microorganisms/Salmonella typhimurium25 µg/plate/90M (+enzymatic activation step)MUREAV 490,45,2001
mutation in microorganisms/Salmonella typhimurium2500 ng/plate (+/-enzymatic activation step)TOLED5 5,11,1980
mutation in microorganisms/Neurospora crassa5 µg/plate (-enzymatic activation step)TOLED5 5,11,1980

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published lethal dose: 5 gm/kgBehavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		ATDAEI 1,167,1992
oral/rat lowest published lethal dose: 5 gm/kgBehavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		ATDAEI 1,167,1992
skin/rabbit Lethal dose: >2 gm/kgATDAEI 1,167,1992
subcutaneous/Dog lowest published lethal dose: 5 gm/kgLiver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Kidney, Ureter, and Bladder: Interstitial nephritis		JIDHAN 2,247,1920

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 5580 mg/kg/90D- continuousBlood: Other changes

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		TOXID9 15,202,1995

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 1.5 mg/m3DTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 1.5 mg/m3 (skin)DTLVS* 3,255,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1.5 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 1.5 mg/m3, inhal, skin, sen, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 1.5 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 1.5 mg/m3, skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 1.5 mg/m3, short term exposure limit 3 mg/m3, skin, NOV2011
Occupational Exposure Limit-FRANCEVME 1.5 mg/m3, Skin, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 1.5 mg/m3, skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 1.5 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 1.5 mg/m3;short term exposure limit 3 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 1.5 mg/m3, sen, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 1,5 mg/m3, JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 1.5 mg/m3, inhal, skin, sen, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 1.5 mg/m3, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 1.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 1.5 mg/m3, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 1.5 mg/m3 (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 1.5 mg/m3 (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 1.5 mg/m3 (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 1.5 mg/m3 (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TETRYL-air10H time-weighted average 1.5 mg/m3 (Sk)NIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/264271/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

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