Registry of Toxic Effects of Chemical Substances (RTECS)
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Aniline, p-nitro-
RTECS #
BY7000000CAS #
100-01-6Updated
September 201Molecular Weight
138.14Molecular Formula
C6H6N2O2Synonyms
1-Amino-4-nitrobenzene4-Nitraniline
4-Nitroaniline
4-Nitrobenzenamine
Aniline, 4-nitro-
Azoamine Red ZH
Azoic Diazo Component 37
Benzenamine, 4-nitro- (9CI)
C.I. 37035
C.I. Azoic Diazo Component 37
C.I. Developer 17
Developer P
Devol Red GG
Diazo Fast Red GG
Fast Red 2G Base
Fast Red Base 2J
Fast Red Base GG
Fast Red GG Base
Fast Red MP Base
Fast Red P Base
Naphtoelan Red GG Base
NCI-C60786
Nitrazol CF Extra
p-Aminonitrobenzene
PNA
p-Nitraniline
p-Nitroanilina (Polish)
p-Nitroaniline
p-Nitroaniline (ACGIH:OSHA)
p-Nitrophenylamine
RCRA waste number P077
Red 2G Base
Shinnippon Fast Red GG Base
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| Cytogenetic Analysis | ovary/hamster | 173 mg/L | EMMUEG 27,67,1996 |
| DNA Damage | other cell types/mouse | 4 µmol/L | MUREAV 715,25,2011 |
| DNA repair | /Bacillus subtilis | 5 mg/disc | MUREAV 170,11,1986 |
| mutation in microorganisms | /Other microorganisms | 1500 µg/L (-enzymatic activation step) | MUREAV 173,233,1986 |
| mutation in microorganisms | /Salmonella typhimurium | 333 µg/plate (+enzymatic activation step) | ENMUDM 5(Suppl 1),3,1983 |
| mutation in microorganisms | /Salmonella typhimurium | 50 µg/plate (-enzymatic activation step) | MUREAV 44,9,1977 |
| phage inhibition capacity | /Escherichia coli | 100 mmol/L | MDMIAZ 31,11,1979 |
| sister chromatid exchange | ovary/hamster | 1600 mg/L | EMMUEG 10(Suppl 10),1,1987 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/rat | 1764 mg/kg (14W male/14W prior to copulation) | Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) | FAATDF 15,607,1990 |
| oral/mouse | 9600 mg/kg (6-13D pregnant) | Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | TCMUD8 7,29,1987 |
| oral/rat | 1190 mg/kg (6-19D pregnant) | Reproductive: Other effects on female | HPV303 -,-,2003 |
| oral/rat | 3500 mg/kg (6-19D pregnant) | Reproductive: Other effects on female Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system | HPV303 -,-,2003 |
| oral/rabbit | 1625 mg/kg (7-19D pregnant) | Reproductive: Other effects on female | HPV303 -,-,2003 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/mouse | lowest published toxic dose: 51500 mg/kg/2Y- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Vascular: Tumors | NTPTR* NTP-TR-418,1993 |
| oral/mouse | lowest published toxic dose: 51500 mg/kg/103W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Liver: Angiosarcoma Blood: Normocytic anemia | NTIS** PB94-104528 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| In Vitro/Non-mammalian species, fibroblast | Inhibitor Concentration (50 percent kill): 1.83 mmol/L/24H | In Vitro Toxicity Studies: Cell counting | TIVIEQ 7,537,1993 |
| intramuscular/mouse | lethal dose (50 percent kill): 800 mg/kg | IGIBA5 15,151,1966 | |
| intraperitoneal/mouse | lethal dose (50 percent kill): 250 mg/kg | NTIS** AD691-490 | |
| intraperitoneal/rat | lowest published lethal dose: 600 mg/kg | 85GMAT -,92,1982 | |
| intravenous/mammal (species unspecified) | lowest published lethal dose: 40 mg/kg | Blood: Methemoglobinemia- Carboxhemoglobinemia | XPHBAO 271,34,1941 |
| oral/guinea pig | lethal dose (50 percent kill): 450 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Convulsions or effect on seizure threshold | VKMGA7 6,89,1966 |
| oral/mouse | lethal dose (50 percent kill): 810 mg/kg | TXAPA9 42,417,1977 | |
| oral/mouse | lowest published lethal dose: 500 mg/kg | Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance Lung, Thorax, or Respiration: Respiratory obstruction Liver: Multiple effects | TPKVAL 7,138,1965 |
| oral/mouse | lowest published lethal dose: 5000 mg/kg | Kidney, Ureter, and Bladder: Other changes Blood: Hemorrhage Blood: Methemoglobinemia- Carboxhemoglobinemia | TPKVAL 7,138,1965 |
| oral/mouse | lowest published lethal dose: 3000 mg/kg | Cardiac: EKG changes not diagnostic of above Blood: Changes in spleen Nutritional and Gross Metabolic: Body temperature decrease | TPKVAL 7,138,1965 |
| oral/mouse | lethal dose (50 percent kill): 1000 mg/kg | Brain and Coverings: Changes in circulation Behavioral: Somnolence (general depressed activity) Cardiac: EKG changes not diagnostic of above | TPKVAL 7,138,1965 |
| oral/quail | lethal dose (50 percent kill): 1 gm/kg | AECTCV 12,355,1983 | |
| oral/rat | lethal dose (50 percent kill): 1400 mg/kg | Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Other changes Liver: Other changes | HPV303 -,-,2003 |
| oral/rat | lethal dose (50 percent kill): 750 mg/kg | CEHYAN 23,168,1978 | |
| oral/wild bird | lethal dose (50 percent kill): 75 mg/kg | TXAPA9 21,315,1972 | |
| skin/guinea pig | lethal dose (50 percent kill): >500 mg/kg | NTIS** OTS0572389 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | lowest published toxic concentration: 510 mg/m3/6H/2W- intermittent | Blood: Other hemolysis with or without anemia Blood: Methemoglobinemia- Carboxhemoglobinemia Blood: Changes in erythrocyte (RBC) count | NTIS** OTS0546534 |
| inhalation/rat | lowest published toxic concentration: 80 mg/m3/6H/4W- intermittent | Endocrine: Changes in spleen weight Blood: Methemoglobinemia- Carboxhemoglobinemia Blood: Changes in leukocyte (WBC) count | FAATDF 6,618,1986 |
| inhalation/rat | lowest published toxic concentration: 10 mg/m3/4W- continuous | Endocrine: Changes in spleen weight Blood: Changes in spleen | HPV303 -,,2003 |
| inhalation/rat | lowest published toxic concentration: 32 mg/m3/4W- continuous | Endocrine: Changes in spleen weight Blood: Methemoglobinemia- Carboxhemoglobinemia Blood: Changes in spleen | HPV303 -,,2003 |
| oral/mouse | lowest published toxic dose: 300 mg/kg/14D- intermittent | Blood: Methemoglobinemia- Carboxhemoglobinemia Blood: Changes in erythrocyte (RBC) count Blood: Changes in platelet count | NTPTR* NTP-TR-418,1993 |
| oral/mouse | lowest published toxic dose: 650 mg/kg/13W- intermittent | Liver: Other changes Blood: Methemoglobinemia- Carboxhemoglobinemia Blood: Changes in spleen | NTPTR* NTP-TR-418,1993 |
| oral/rat | lowest published toxic dose: 270 mg/kg/90D- continuous | Blood: Methemoglobinemia- Carboxhemoglobinemia Blood: Changes in spleen | HPV303 -,,2003 |
| oral/rat | lowest published toxic dose: 900 mg/kg/90D- continuous | Endocrine: Changes in spleen weight Blood: Methemoglobinemia- Carboxhemoglobinemia Blood: Changes in erythrocyte (RBC) count | HPV303 -,,2003 |
| oral/rat | lowest published toxic dose: 6750 mg/kg/2W- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTIS** OTS0533716 |
| oral/rat | lowest published toxic dose: 2700 mg/kg/90D- intermittent | Blood: Methemoglobinemia- Carboxhemoglobinemia Blood: Changes in spleen Blood: Changes in other cell count (unspecified) | TOXID9 3,128,1983 |
| oral/rat | lowest published toxic dose: 120 mg/kg/30D- intermittent | Blood: Methemoglobinemia- Carboxhemoglobinemia Blood: Changes in erythrocyte (RBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain | GISAAA 50(4),82,1985 |
| oral/rat | lowest published toxic dose: 180 mg/kg/26W- intermittent | Behavioral: Alteration of classical conditioning Blood: Methemoglobinemia- Carboxhemoglobinemia Blood: Changes in erythrocyte (RBC) count | GISAAA 50(4),82,1985 |
| oral/rat | lowest published toxic dose: 6552 mg/kg/2Y- intermittent | Blood: Methemoglobinemia- Carboxhemoglobinemia Blood: Changes in erythrocyte (RBC) count Endocrine: Changes in spleen weight | FAATDF 15,607,1990 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 3 mg/m3 (skin) | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | MUREAV 543,201,2003 | |
| TOXICOLOGY REVIEW | MUREAV 567,347,2004 | |
| TOXICOLOGY REVIEW | MUREAV 584,1,2005 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 1 ppm (6 mg/m3) (skin) | DTLVS* 3,182,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-ARAB Republic of Egypt | time-weighted average 1 ppm (6 mg/m3), Skin, JAN1993 | |
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 3 mg/m3, JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 1 ppm (6 mg/m3), skin, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 3 mg/m3, Skin, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 0.5 ppm (3 mg/m3), skin, MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 1 ppm (5.7 mg/m3), short term exposure limit 3 ppm (17 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 3 mg/m3, Skin, FEB2006 | |
| Occupational Exposure Limit-HUNGARY | time-weighted average 6 mg/m3, Skin, SEP2000 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 0.5 ppm (3 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-JAPAN | Occupational Exposure Limit 3 mg/m3, skin, MAY2012 | |
| Occupational Exposure Limit-KOREA | time-weighted average 3 mg/m3, skin, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 1 ppm (6 mg/m3) (skin), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 3 mg/m3, skin, JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 1 mg/m3, JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 3 mg/m3, JUL2005 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 3 mg/m3, MAC(short term exposure limit) 10 mg/m3, JAN1999 | |
| Occupational Exposure Limit-RUSSIA | time-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, Skin, JUN2003 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 0.5 ppm (3 mg/m3), skin, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 6 mg/m3, Skin, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 1 ppm (6 mg/m3), Skin, JAN1993 | |
| Occupational Exposure Limit-TURKEY | time-weighted average 1 ppm (6 mg/m3), Skin, JAN1993 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 1 ppm (6 mg/m3) (skin) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 1 ppm (6 mg/m3) (skin) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 1 ppm (6 mg/m3) (skin) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 1 ppm (6 mg/m3) (skin) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO p-NITROANILINE-air | 10H time-weighted average 3 mg/m3 (Sk) | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code M3131; Number of Industries 2; Total Number of Facilities 48; Number of Occupations 7; Total Number of Employees Exposed 1448; Total Number of Female Employees Exposed 262 | |
| National Occupational Hazard Survey 1974 | Hazard Code M3131; Number of Industries 4; Total Number of Facilities 281; Number of Occupations 10; Total Number of Employees Exposed 2814 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse | |
| EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE | FEREAC 47,26992,82 |
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| EPA TSCA Section 8(d) unpublished health/safety studies | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
| NCI Carcinogenesis Studies (gavage);equivocal evidence:rat | |
| NIOSH Analytical Method, 1994: p-Nitroaniline, 5033 |
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division