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Registry of Toxic Effects of Chemical Substances (RTECS)

o-Anisidine

RTECS #

BZ5410000

CAS #

90-04-0

Updated

September 201

Molecular Weight

123.17

Molecular Formula

C7H9NO

Synonyms

1-Amino-2-methoxybenzene
2-Aminoanisole
2-Anisidine
2-Methoxy-1-aminobenzene
2-Methoxyaniline
2-Methoxybenzenamine
2-Methoxyphenylamine
Benzenamine, 2-methoxy- (9CI)
o-Aminoanisole
o-Anisidine (ACGIH:OSHA)
o-Anisylamine
o-Methoxyaniline
o-Methoxyphenylamine

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster1200 mg/LEMMUEG 10(Suppl 10),1,1987
DNA Damagelymphocyte/mouse1250 µmol/LMUREAV 203,155,1988
DNA Damageoral/mouse690 mg/kgMUREAV 412,155,1998
DNA inhibitionoral/mouse200 mg/kgMUREAV 46,305,1977
DNA repair/Escherichia coli31600 µmol/LMUREAV 272,145,1992
gene conversion and mitotic recombination/Drosophila melanogaster1 mmol/LMUREAV 514,193,2002
host-mediated assayEscherichia coli/mouse310 mg/kgMUREAV 272,161,1992
mutation in mammalian somatic cellslymphocyte/mouse2 mmol/LMUTAEX 3,193,1988
mutation in microorganisms/Salmonella typhimurium333 µg/plate (-enzymatic activation step)IMEMDT 27,63,1982
mutation in microorganismslymphocyte/mouse1 mmol/L (+enzymatic activation step)MUTAEX 3,193,1988
sister chromatid exchangeovary/hamster38 mg/LEMMUEG 10(Suppl 10),1,1987

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/mouse lethal dose (50 percent kill): 1400 mg/kgKidney, Ureter, and Bladder: Other changes

Blood: Normocytic anemia

Blood: Other changes		IMEMDT 27,63,1982
oral/rabbit lethal dose (50 percent kill): 870 mg/kgKidney, Ureter, and Bladder: Other changes

Blood: Normocytic anemia

Blood: Other changes		IMEMDT 27,63,1982
oral/rat lethal dose (50 percent kill): 1150 mg/kgTLSMA6 128,14,1979
oral/wild bird lethal dose (50 percent kill): 422 mg/kgAECTCV 12,355,1983

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.5 mg/m3 (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 73,49,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 27,63,1982
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 73,49,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 73,49,1999
TOXICOLOGY REVIEWENTOX* -,104,2005
TOXICOLOGY REVIEWMUREAV 752,99,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.1 ppm (0.5 mg/m3) (skin)DTLWS* 3,10,1973
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 ppm (0.5 mg/m3), JAN1993
Occupational Exposure Limit-AUSTRIATRK-TMW 0.1 ppm (0.5 mg/m3);KZW 0.2 ppm (1 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 ppm (0.5 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.1 ppm (0.5 mg/m3), skin, carc, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.1 ppm (0.5 mg/m3), short term exposure limit 0.3 ppm (1.5 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 0.1 ppm (0.5 mg/m3), Skin, C2 Carcinogen, FEB2006
Occupational Exposure Limit-HUNGARYceiling concentration 0.5 mg/m3, Carcinogen, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 0.1 ppm (0.5 mg/m3), carc, skin, NOV2011
Occupational Exposure Limit-INDIAtime-weighted average 0.1 ppm (0.5 mg/m3), Skin, JAN1993
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.1 ppm (0.5 mg/m3), skin, 2B carc, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 0.5 mg/m3, skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.1 ppm (0.5 mg/m3) (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 ppm (0.5 mg/m3), skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.1 ppm (0.5 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0.1 ppm (0.5 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.5 mg/m3, MAC(short term exposure limit) 1 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 ppm (0.5 mg/m3), carc 2, skin, JAN2011
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.5 mg/m3, Skin, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.5 mg/m3 (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.5 mg/m3 (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.5 mg/m3 (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.5 mg/m3 (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO o-ANISIDINE-air10H Carcinogen time-weighted average 0.5 mg/m3 (Sk)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code X8302; Number of Industries 1; Total Number of Facilities 50; Number of Occupations 3; Total Number of Employees Exposed 705

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Anisidine, 2514
On EPA IRIS database

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