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Registry of Toxic Effects of Chemical Substances (RTECS)

Anisole, 2,4-diamino-

RTECS #

BZ8580500

CAS #

615-05-4

Updated

July 2013

Molecular Weight

138.19

Molecular Formula

C7H10N2O

Synonyms

1,3-Benzenediamine, 4-methoxy- (9CI)
2,4-Diamineanisole
2,4-Diamino-1-methoxybenzene
2,4-Diaminoanisole
2,4-Diaminoanisole base
4-Methoxy-1,3-benzenediamine
4-Methoxy-m-phenylenediamine
C.I. 76050
C.I. Oxidation Base 12
Furro L
m-Diaminoanisole 1,3-diamino-4-methoxybenzene
m-Phenylenediamine, 4-methoxy- (8CI)
Pelagol DA
Pelagol Grey L
Pelagol L
p-Methoxy-m-phenylenediamine

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 12500 µg/24H mildFCTXAV 15,607,1977

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA adductliver/rat500 µmol/LCBINA8 31,35,1980
DNA Damagefibroblast/human50 µmol/LMUREAV 127,107,1984
DNA Damageintraperitoneal/rat660 µmol/kgCRNGDP 2,1317,1981
mutation in mammalian somatic cellslymphocyte/mouse18750 gm/LJEPTDQ 1(1),87,1977
mutation in microorganisms/Salmonella typhimurium1 nmol/plate/20MEMMUEG 38,268,2001
mutation in microorganisms/Salmonella typhimurium50 µg/plate (-enzymatic activation step)CRNGDP 7,899,1986
sister chromatid exchangeintraperitoneal/mouse12 mg/kgMUREAV 108,225,1983

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
subcutaneous/mammal (species unspecified) 65100 µg/kg (10D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)JIDOAA 35,387,1986

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lethal dose (50 percent kill): 116 mg/kgKidney, Ureter, and Bladder: Urine volume increased

Kidney, Ureter, and Bladder: Other changes in urine composition		BCPCA6 30,2715,1981
oral/rat lethal dose (50 percent kill): 460 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Skin and Appendages: Other: Hair		FCTXAV 15,607,1977

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 3780 mg/kg/6W- continuousEndocrine: Evidence of thyroid hypofunction

Endocrine: Other changes		BMERE* 12,77,1991

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 79,-,2000
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 79,-,2000
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 79,-,2000
TOXICOLOGY REVIEWMUREAV 567,347,2004
TOXICOLOGY REVIEWIMEMDT 79,621,
TOXICOLOGY REVIEWTXAPA9 243,239,2010

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-JAPAN2B carc, MAY2012
Occupational Exposure Limit-SWEDENGroup B Carcinogen, JUN2005
Occupational Exposure Limit-SWITZERLANDcarc 2, JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 2,4-DIAMINOANISOLE-airCarcinogen lowest feasible conc.NIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal; Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 19, 1978

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