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Registry of Toxic Effects of Chemical Substances (RTECS)

Asphalt

RTECS #

CI9900000

CAS #

8052-42-4

Updated

September 201

Molecular Weight

N/R

Molecular Formula

N/R

Synonyms

Asphalt fumes (ACGIH)
Asphalt, petroleum
Asphaltum
Bitumen
Bitumen fumes
Judean pitch
Mineral pitch
Petroleum asphalt
Petroleum bitumen
Petroleum pitch
Petroleum roofing tar
Road asphalt

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA adductskin/mouse600 mg/kgCRNGDP 9,1253,1988
DNA Damageother cell types/rat641 µg/LMUREAV 557,137,2004
micronucleus testother cell types/rat57.8 µg/LMUREAV 557,137,2004

Tumorigenic Data and References

Route/OrganismDoseEffectReference
intramuscular/mouse lowest published toxic dose: 12 gm/kg/12W- intermittentTumorigenic: Neoplastic by RTECS criteria

Tumorigenic: Tumors at site of application		ARPAAQ 70,372,1960
intramuscular/rat lowest published toxic dose: 5400 mg/kg/24W- intermittentTumorigenic: Neoplastic by RTECS criteria

Tumorigenic: Facilitates action of known carcinogens		ARPAAQ 70,372,1960
skin/mouse lowest published toxic dose: 130 gm/kg/81W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors		HYSAAV 33(4-6),180,1968
skin/mouse toxic dose: 69 gm/kg/43W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors		HYSAAV 33(4-6),180,1968
skin/mouse lowest published toxic dose: 905 gm/kg/2Y- intermittentTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors		IMSUAI 34,255,1965

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): >94.4 mg/m3HPV123 -,-,2002
oral/rat lethal dose (50 percent kill): >5000 mg/kgGastrointestinal: Hypermotility, diarrheaHPV123 -,-,2002

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic dose: 10 mg/m3/5.5Y- intermittentEye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough

Gastrointestinal: Changes in structure or function of salivary glands		ARTODN 81,35,2007
inhalation/human lowest published toxic dose: 10 mg/m3/9Y- intermittentLung, Thorax, or Respiration: Other changes

Gastrointestinal: Changes in structure or function of salivary glands

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation		ARTODN 81,35,2007
inhalation/mouse lowest published toxic concentration: 35 mg/m3/10D- intermittentImmunological Including Allergic: Decrease in humoral immune responseTOXID9 60,27,2001
inhalation/rat lowest published toxic concentration: 100 mg/m3/14W- intermittentKidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects		HPV123 -,-,2002
inhalation/rat lowest published toxic concentration: 100 mg/m3/6H/14W- intermittentOlfaction: Tumors

Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		TOLED5 135,S140,2002
intratracheal/rat lowest published toxic dose: 1.35 mg/kg/3D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)JJTHEC 65,1247,2002
intratracheal/rat lowest published toxic dose: 26.64 mg/kg/3D- intermittentBlood: Changes in bone marrow not included in aboveJJTHEC 65,1247,2002

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.5 mg/m3 (inhal)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 35,39,1985
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,133,1987

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,101,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 5 mg/m3 (fume)DTLVS* 3,19,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 5 mg/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 5 mg/m3 (fume), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 1 mg/m3, MAY2011
Occupational Exposure Limit-ICELANDtime-weighted average 5 mg/m3, NOV2011
Occupational Exposure Limit-JAPAN2B carc, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 5 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 10 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 5 mg/m3 (fume), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0.5 mg/m3, JUL2005
Occupational Exposure Limit-POLANDtime-weighted average 5 mg/m3 (fume), short term exposure limit 15 mg/m3 (fume), JAN1999
Occupational Exposure Limit-SWITZERLANDMAK-week 10 mg/m3, carc 3, skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 5 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 5 mg/m3;short term exposure limit 10 mg/m3, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ASPHALT FUMES-airCarcinogen ceiling concentration 5 mg/m3/15MNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 90320; Number of Industries 177; Total Number of Facilities 26349; Number of Occupations 109; Total Number of Employees Exposed 471039; Total Number of Female Employees Exposed 18959
National Occupational Hazard Survey 1974Hazard Code 90320; Number of Industries 175; Total Number of Facilities 38326; Number of Occupations 111; Total Number of Employees Exposed 573807

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; selected, October 2000

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