Registry of Toxic Effects of Chemical Substances (RTECS)
Barium chloride
RTECS #
CQ8750000CAS #
10361-37-2Updated
September 201Molecular Weight
208.24Molecular Formula
BaCl2Synonyms
Barium dichlorideNCI-C61074
SBA 0108E
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
gene conversion and mitotic recombination | /Saccharomyes cerevisiae | 14 mmol/L | MUTAEX 1,21,1986 |
Reproductive Effects Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
intratesticular/rat | 16659 µg/kg (1D male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct | JRPFA4 7,21,1964 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
In Vitro/Guinea pig, myocard | Inhibitor Concentration Low: 1 mmol/L/30M | Cardiac: Pulse rate increased without fall in BP | TIVIEQ 2,49,1988 |
In Vitro/Human, liver tumor | Inhibitor Concentration (50 percent kill): 2.1 mmol/L/24H | In Vitro Toxicity Studies: Cell protein synthesis | TIVIEQ 3,189,1989 |
In Vitro/Human, melanoma | Inhibitor Concentration Low: 0.03 µmol/L | Gastrointestinal: Contraction (isolated tissue) | FTRPAE 83,1286,2012 |
In Vitro/Rat, kidney | Inhibitor Concentration Low: 300 µmol/L | In Vitro Toxicity Studies: Membrane currents | TXCYAC 271,45,2010 |
intracerebral/mouse | lethal dose (50 percent kill): 2.4 mg/kg | HBTME* -,407,2007 | |
intraperitoneal/mouse | lethal dose (50 percent kill): 56.2 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Tetany | VCVN1* -,136,1988 |
intraperitoneal/mouse | lethal dose (50 percent kill): 39 mg/kg | FATOBP 10,107,1975 | |
intraperitoneal/rat | lethal dose (50 percent kill): 24 mg/kg | HBTME* -,407,2007 | |
intravenous/cat | lowest published lethal dose: 40 mg/kg | EQSSDX 1,1,1975 | |
intravenous/mouse | lethal dose (50 percent kill): 12 mg/kg | TXAPA9 22,150,1972 | |
intravenous/rabbit | lowest published lethal dose: 15 mg/kg | EQSSDX 1,1,1975 | |
intravenous/rabbit | lowest published toxic dose: 4 mg/kg | Cardiac: Arrythmias (indlucing changes in conduction) | FATOAO 51,50,1988 |
intravenous/rat | lowest published lethal dose: 20 mg/kg | Behavioral: Muscle contraction or spasticity Lung, Thorax, or Respiration: Other changes | JLCMAK 15,35,1929 |
oral/Dog | lowest published lethal dose: 90 mg/kg | HBTME* -,407,2007 | |
oral/guinea pig | lethal dose (50 percent kill): 76 mg/kg | FOREAE 7,313,1942 | |
oral/horse, donkey | lowest published lethal dose: 800 mg/kg | HBTME* -,407,2007 | |
oral/mammal (species unspecified) | lethal dose (50 percent kill): 398 mg/kg | Autonomic Nervous System: Other (direct) parasympathomimetic Behavioral: Muscle weakness Gastrointestinal: Nausea or vomiting | GTPZAB 28(6),45,1984 |
oral/mouse | lethal dose (50 percent kill): 150 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Tetany | VCVN1* -,136,1988 |
oral/mouse | lowest published lethal dose: 70 mg/kg | EQSSDX 1,1,1975 | |
oral/rabbit | lowest published lethal dose: 170 mg/kg | HBTME* -,407,2007 | |
oral/rat | lowest published lethal dose: 300 mg/kg | HBTME* -,407,2007 | |
oral/rat | lethal dose (50 percent kill): 397 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Tetany | VCVN1* -,136,1988 |
oral/rat | lethal dose (50 percent kill): 118 mg/kg | FOREAE 7,313,1942 | |
parenteral/domestic animal | lowest published lethal dose: 7 mg/kg | Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change Behavioral: Muscle weakness | NEZTAF 47,150,1999 |
parenteral/rabbit | lowest published lethal dose: 20 mg/kg | Gastrointestinal: Hypermotility, diarrhea Kidney, Ureter, and Bladder: Urine volume increased | MELAAD 30,44,1939 |
parenteral/rat | lowest published toxic dose: 35 µg/kg | Cardiac: Arrythmias (indlucing changes in conduction) | PCJOAU 37,6,2003 |
subcutaneous/cat | lowest published lethal dose: 18 mg/kg | EQSSDX 1,1,1975 | |
subcutaneous/Dog | lowest published lethal dose: 10 mg/kg | EQSSDX 1,1,1975 | |
subcutaneous/frog | lowest published lethal dose: 910 mg/kg | HBAMAK 4,1289,1935 | |
subcutaneous/guinea pig | lowest published lethal dose: 55 mg/kg | 27ZIAQ -,53,1973 | |
subcutaneous/mouse | lowest published lethal dose: 10 mg/kg | NTIS** AEC-TR-6710 | |
subcutaneous/rabbit | lowest published lethal dose: 40 mg/kg | EQSSDX 1,1,1975 | |
subcutaneous/rat | lethal dose (50 percent kill): 178 mg/kg | 27ZIAQ -,53,1973 | |
unreported route/Dog | lethal dose (50 percent kill): 90 mg/kg | NEZTAF 47,150,1999 | |
unreported route/horse, donkey | lethal dose (50 percent kill): 800 mg/kg | NEZTAF 47,150,1999 | |
unreported route/human | lowest published lethal dose: 114.3 mg/kg | VCVN1* -,138,1988 | |
unreported route/mouse | lethal dose (50 percent kill): 7 mg/kg | NEZTAF 47,150,1999 | |
unreported route/rabbit | lethal dose (50 percent kill): 170 mg/kg | NEZTAF 47,150,1999 | |
unreported route/rat | lethal dose (50 percent kill): 150 mg/kg | NEZTAF 47,150,1999 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/rat | lowest published toxic dose: 91 mg/kg/26W- intermittent | Behavioral: Alteration of classical conditioning Blood: Changes in leukocyte (WBC) count Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | GISAAA 45(6),86,1980 |
oral/rat | lowest published toxic dose: 3 gm/kg/10D- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field Related to Chronic Data: Changes in ovarian weight | JACTDZ 7(5),675,1988 |
oral/rat | lowest published toxic dose: 70 mg/kg/4W- continuous | Cardiac: Other changes Vascular: BP elevation not characterized in autonomic section | VCVN1* -,138,1988 |
oral/rat | lowest published toxic dose: 84 mg/kg/24W- intermittent | Behavioral: Alteration of classical conditioning Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | VCVN1* -,138,1988 |
subcutaneous/rat | lowest published toxic dose: 280 mg/kg/4W- intermittent | Liver: Other changes Endocrine: Other changes Blood: Changes in leukocyte (WBC) count | VCVN1* -,138,1988 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.5 mg(Ba)/m3 | DTLVS* TLV/BEI,2013 |
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
TOXICOLOGY REVIEW | FOREAE 7,313,1942 | |
TOXICOLOGY REVIEW | JTEHD6 4,395,2001 | |
TOXICOLOGY REVIEW | HBTME* ,407,2007 | |
TOXICOLOGY REVIEW | NBREV* 5,1,1981 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 0.5 mg(Ba)/m3 | DTLVS* 3,21,1971 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
Occupational Exposure Limit-AUSTRALIA | time-weighted average 0.5 mg(Ba)/m3, JUL2008 | |
Occupational Exposure Limit-BELGIUM | time-weighted average 0.5 mg(Ba)/m3, MAR2002 | |
Occupational Exposure Limit-DENMARK | time-weighted average 0.5 mg(Ba)/m3, MAY2011 | |
Occupational Exposure Limit-EC | time-weighted average 0.5 mg(Ba)/m3, FEB2006 | |
Occupational Exposure Limit-FINLAND | time-weighted average 0.5 mg(Ba)/m3, NOV2011 | |
Occupational Exposure Limit-FRANCE | VME 0.5 mg(Ba)/m3, FEB2006 | |
Occupational Exposure Limit-GERMANY | MAK 0.5 mg(Ba)/m3, inhal, 2011 | |
Occupational Exposure Limit-HUNGARY | time-weighted average 0.5 mg(Ba)/m3, short term exposure limit 2 mg(Ba)/m3, SEP2000 | |
Occupational Exposure Limit-KOREA | time-weighted average 0.5 mg(Ba)/m3, 2006 | |
Occupational Exposure Limit-MEXICO | time-weighted average 0.5 mg(Ba)/m3, 2004 | |
Occupational Exposure Limit-NEW ZEALAND | time-weighted average 0.5 mg(Ba)/m3, JAN2002 | |
Occupational Exposure Limit-NORWAY | time-weighted average 0.5 mg(Ba)/m3, JAN1999 | |
Occupational Exposure Limit-POLAND | MAC(time-weighted average) 0.5 mg(Ba)/m3, MAC(short term exposure limit) 1.5 mg(Ba)/m3, JAN1999 | |
Occupational Exposure Limit-RUSSIA | time-weighted average 0.3 mg/m3, short term exposure limit 1 mg/m3, JUN2003 | |
Occupational Exposure Limit-SWEDEN | time-weighted average 0.5 mg(Ba)/m3, JUN2005 | |
Occupational Exposure Limit-SWITZERLAND | MAK-week 0.5 mg(Ba)/m3, KZG-week 1 mg(Ba)/m3, inhal, JAN2011 | |
Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 0.5 mg(Ba)/m3, 2003 | |
Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 0.5 mg(Ba)/m3, JAN1993 | |
Occupational Exposure Limit-TURKEY | time-weighted average 0.5 mg(Ba)/m3, JAN1993 | |
Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 0.5 mg(Ba)/m3, sen, OCT2007 | |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 0.5 mg(Ba)/m3 | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 0.5 mg(Ba)/m3 | CFRGBR 41,50-204.50,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 0.5 mg(Ba)/m3 | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 0.5 mg(Ba)/m3 | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
Status in Federal Agencies
Organization | Reference |
---|---|
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE; B subtilis rec assay | |
EPA TSCA Section 8(b) CHEMICAL INVENTORY |
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division