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Registry of Toxic Effects of Chemical Substances (RTECS)

1,3-Benzenedicarbonitrile

RTECS #

CZ1900000

CAS #

626-17-5

Updated

September 201

Molecular Weight

128.14

Molecular Formula

C8H4N2

Synonyms

1,3-Benzendikarbonitril (Czech)
1,3-Dicyanobenzene
Dinitrile of isophthalic acid
IPN
Isoftalodinitril (Czech)
Isoftalonitril (Czech)
Isophthalodinitrile
Isophthalonitrile
m-Dicyanobenzene
m-Phthalodinitrile
m-Phthalodinitrile (ACGIH)
Nitril kyseliny isoftalove (Czech)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg/24H mild85JCAE -,905,1986

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): >8970 mg/m3/1HNTIS** OTS0533488
inhalation/rat lethal concentration (50 percent kill): >8970 mg/m3/1HLung, Thorax, or Respiration: Other changes

Blood: Hemorrhage

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		HPV271 -,-,2005
intraperitoneal/mouse lethal dose (50 percent kill): 450 mg/kgBehavioral: Convulsions or effect on seizure thresholdZAARAM 19,225,1969
intraperitoneal/rat lethal dose (50 percent kill): 520 mg/kgEye: Ptosis

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Acute pulmonary edema		APFRAD 48,23,1990
oral/cat lethal dose (50 percent kill): 500 mg/kgZAARAM 19,225,1969
oral/mouse lethal dose (50 percent kill): 369 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression		HPV271 -,-,2005
oral/mouse lethal dose (50 percent kill): 178 mg/kgJMCMAR 21,906,1978
oral/rabbit lethal dose (50 percent kill): 250 mg/kgZAARAM 19,225,1969
oral/rat lethal dose (50 percent kill): 1790 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes		HPV271 -,-,2005
oral/rat lethal dose (50 percent kill): 860 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Body temperature decrease		NTIS** OTS0533488
skin/rabbit lethal dose (50 percent kill): >2000 mg/kgHPV271 -,-,2005
skin/rat lethal dose (50 percent kill): >5 gm/kgNTIS** OTS0533488
unreported route/guinea pig lethal dose (50 percent kill): 370 mg/kgGISAAA 39(11),17,1974
unreported route/mouse lethal dose (50 percent kill): 548 mg/kgGISAAA 39(11),17,1974
unreported route/rabbit lethal dose (50 percent kill): 350 mg/kgGISAAA 39(11),17,1974
unreported route/rat lethal dose (50 percent kill): 1708 mg/kgGISAAA 39(11),17,1974

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 1250 mg/m3/6H/2W- intermittentGastrointestinal: Hypermotility, diarrhea

Skin and Appendages: Other: Hair

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		NTIS** OTS0533488
inhalation/rat lowest published toxic concentration: 1500 mg/m3/2W- intermittentBehavioral: Food intake (animal)

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		HPV271 -,-,2005
oral/mouse lowest published toxic dose: 13500 mg/kg/90D- intermittentBrain and Coverings: Changes in brain weight

Liver: Changes in liver weight

Related to Chronic Data: Changes in ovarian weight		NTIS** OTS0572435
oral/mouse lowest published toxic dose: 5250 mg/kg/35D- continuousLiver: Other changes

Liver: Changes in liver weight		NTIS** OTS0538085
oral/mouse lowest published toxic dose: 6300 mg/kg/35D- intermittentLiver: Other changes

Liver: Changes in liver weight		HPV271 -,-,2005
oral/mouse lowest published toxic dose: 12600 mg/kg/35D- intermittentLiver: Other changes

Liver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		HPV271 -,-,2005
oral/rabbit lowest published toxic dose: 4550 mg/kg/26W- intermittentLiver: Liver function tests impaired

Liver: Other changes

Blood: Pigmented or nucleated red blood cells		GISAAA 39(11),17,1974
oral/rat lowest published toxic dose: 495 mg/kg/99D- intermittentKidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Other proteins		HPV271 -,-,2005
oral/rat lowest published toxic dose: 2475 mg/kg/99D- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Other proteins		HPV271 -,-,2005
oral/rat lowest published toxic dose: 2475 mg/kg/99D- intermittentLiver: Other changes

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Urine volume increased		NTIS** OTS0537740
oral/rat lowest published toxic dose: 5250 mg/kg/1W- intermittentBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		NTIS** OTS0533488
oral/rat lowest published toxic dose: 4050 mg/kg/30D- intermittentBehavioral: Food intake (animal)

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		NTIS** OTS0533488
skin/rabbit lowest published toxic dose: 15000 mg/kg/21D- intermittentEndocrine: Evidence of thyroid hypofunction

Related to Chronic Data: Changes in ovarian weight		HPV271 -,-,2005
skin/rabbit lowest published toxic dose: 30000 mg/kg/21D- intermittentEndocrine: Evidence of thyroid hypofunction

Endocrine: Changes in spleen weight

Related to Chronic Data: Changes in ovarian weight		HPV271 -,-,2005

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 5 mg/m3 (inhal, vapor)DTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 5 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 5 mg/m3;KZW 10 mg/m3, inhal, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 5 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 5 mg/m3, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 5 mg/m3, short term exposure limit 20 mg/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 5 mg/m3, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 5 mg/m3, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 5 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 5 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 5 mg/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 5 mg/m3, JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 5 mg/m3, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 5 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO m-PHTHALODINITRILE-air10H time-weighted average 5 mg/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code X3037; Number of Industries 1; Total Number of Facilities 4; Number of Occupations 5; Total Number of Employees Exposed 208; Total Number of Female Employees Exposed 44

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

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