Registry of Toxic Effects of Chemical Substances (RTECS)

Benzene, 2,4-diisocyanato-1-methyl-

RTECS #

CZ6300000

CAS #

584-84-9

Updated

September 201

Molecular Weight

174.17

Molecular Formula

C₉H₆N₂O₂

Synonyms

2,4-Diisocyanato-1-methylbenzene (9CI)
2,4-Diisocyanatotoluene
2,4-TDI
2,4-Toluenediisocyanate
2,4-Tolylenediisocyanate
4-Methyl-phenylene diisocyanate
4-Methyl-phenylene isocyanate
Cresorcinol diisocyanate
Desmodur T80
Di-isocyanate de toluylene (French)
Di-iso-cyanatoluene
Diisocyanat-toluol (German)
Hylene T
Isocyanic acid, 4-methyl-m-phenylene ester
Mondur TD
Mondur TD-80
Mondur TDS
Nacconate IOO
NCI-C50533
RCRA waste number U223
TDI
TDI (OSHA)
TDI-80
Tolueen-diisocyanaat (Dutch)
Toluen-disocianato (Italian)
Toluene 2,4-diisocyanate
Toluene diisocyanate
Toluene-2,4-diisocyanate
Toluene-2,4-diisocyanate (ACGIH:OSHA)
Toluilenodwuizocyjanian (Polish)
Toluylene-2,4-diisocyanate
Tolyene 2,4-diisocyanate
Tolylene-2,4-diisocyanate
Tuluylendiisocyanat (German)

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	100 mg	severe	EJTXAZ 9,41,1976
skin /rabbit	500 mg open irritation test	severe	UCDS** 3/8/1973
skin /rabbit	500 mg/24H	moderate	EJTXAZ 9,41,1976

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
micronucleus test	inhalation/rat	0.05 ppm/6H/4W	CRTXB2 31,737,2001
morphological transform	fibroblast/mouse	0.2 mg/L/21D (-enzymatic activation step)	EMMUEG 37,231,2001
mutation in microorganisms	/Salmonella typhimurium	0.033 mg/plate (+enzymatic activation step)	CRTXB2 31,737,2001
mutation in microorganisms	/Salmonella typhimurium	100 µg/plate (-enzymatic activation step)	ENMUDM 9(Suppl 9),1,1987
sister chromatid exchange	ovary/hamster	300 mg/L	EMMUEG 13,133,1989
specific locus test	lymphocyte/mouse	75 mg/L	EMMUEG 17,196,1991

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/guinea pig	lethal concentration (50 percent kill): 13 ppm/4H	Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance Lung, Thorax, or Respiration: Pleural effusion	AIHAAP 23,447,1962
inhalation/human	lowest published toxic concentration: 20 ppb/2Y	Lung, Thorax, or Respiration: Cough Lung, Thorax, or Respiration: Sputum	PRSMA4 63,372,1970
inhalation/human	lowest published toxic concentration: 500 ppb	Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Other changes	JOCMA7 1,448,1959
inhalation/human	lowest published toxic concentration: 80 ppb	Olfaction: Other olfaction effects Eye: Other eye effects Lung, Thorax, or Respiration: Other changes	ATXKA8 19,364,1962
inhalation/mouse	lethal concentration (50 percent kill): 10 ppm/4H	Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance	AIHAAP 23,447,1962
inhalation/mouse	lethal concentration (50 percent kill): 10 ppm/4H		ENTOX* -,204,2005
inhalation/rabbit	lethal concentration (50 percent kill): 11 ppm/4H	Behavioral: Excitement Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Changes in structure or function of salivary glands	AIHAAP 23,447,1962
inhalation/rat	lowest published toxic concentration: 0.004 gm/m³/4H	Liver: Hepatitis (hepatocellular necrosis), zonal	TPKVAL 9,37,1967
inhalation/rat	lethal concentration (50 percent kill): 14 ppm/4H		ENTOX* -,204,2005
inhalation/rat	lethal concentration (50 percent kill): 14 ppm/4H	Eye: Lacrimation Behavioral: Excitement Lung, Thorax, or Respiration: Dyspnea	AIHAAP 23,447,1962
inhalation/woman	lowest published toxic concentration: 300 ppt/8H/5D	Lung, Thorax, or Respiration: Respiratory obstruction	LANCAO 1,756,1980
intravenous/mouse	lethal dose (50 percent kill): 56 mg/kg		CSLNX* NX#07807
oral/rat	lethal dose (50 percent kill): 5800 mg/kg	Gastrointestinal: Other changes	AMIHAB 15,324,1957
oral/rat	lethal dose (30 percent kill): 6.17 gm/kg		ENTOX* -,204,2005
oral/wild bird	lethal dose (50 percent kill): 100 mg/kg		AECTCV 12,355,1983
skin/rabbit	lethal dose (50 percent kill): >16 mL/kg		UCDS** 3/8/1973

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/guinea pig	lowest published toxic concentration: 3100 ppb/4H/5D- intermittent	Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Blood: Changes in leukocyte (WBC) count	EXLRDA 11,145,1986
inhalation/mouse	lowest published toxic concentration: 990 ppb/6H/14D- intermittent	Olfaction: Other olfaction effects	JJATDK 15,207,1995
inhalation/rabbit	lowest published toxic dose: 1500 ppb/71D- intermittent	Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	AMIHAB 15,324,1957
inhalation/rabbit	lowest published toxic concentration: 1500 ppb/6H/79D- intermittent	Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi	AMIHAB 15,324,1957
inhalation/rat	lowest published toxic concentration: 204 µg/m³/24H/84D- continuous	Behavioral: Muscle contraction or spasticity Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Metabolism (intermediary): Lipids including transport	GISAAA 28(6),8,1963
inhalation/rat	lowest published toxic concentration: 102 ppb/24H/7D- continuous	Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi	JJATDK 14,369,1994
inhalation/rat	lowest published toxic concentration: 26 ppm/6H/5W- intermittent	Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTIS** OTS0570993
intradermal/mouse	lowest published toxic dose: 500 mg/kg/3D- intermittent	Skin: After topical application: Cutaneous sensitization (experimental)	EXPDE* 15,322,2006
intratracheal/rat	lowest published toxic dose: 48.84 µL/kg/21D- intermittent	Immunological Including Allergic: Other immediate (humoral): uticaria, allergic rhinitis, serum sickness (multiple organ involvement) Biochemical: Metabolism (intermediary): Histamines (including liberation not immunochemical in origin)	JPHSC* 109,606,2009
multiple/mouse	lowest published toxic dose: 0.3 pph/3D- intermittent	Lung, Thorax, or Respiration: Bronchiolar constriction, including asthma Lung, Thorax, or Respiration: Acute pulmonary edema Lung, Thorax, or Respiration: Changes in lung weight	TOXID9 72,43,2003
oral/guinea pig	lowest published toxic dose: 70 mg/kg/7D- intermittent	Immunological Including Allergic: Other immediate (humoral): uticaria, allergic rhinitis, serum sickness (multiple organ involvement) Biochemical: Metabolism (intermediary): Histamines (including liberation not immunochemical in origin)	ACPSI* 24,251,2003
oral/rat	lowest published toxic dose: 15 gm/kg/10D- intermittent	Gastrointestinal: Other changes Liver: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	AMIHAB 15,324,1957
skin/mouse	lowest published toxic dose: 1 pph/3D- intermittent	Immunological Including Allergic: Increased immune response Biochemical: Metabolism (intermediary): Other proteins Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	TXCYAC 261,103,2009
skin/mouse	lowest published toxic dose: 90 mg/kg/3D- intermittent	Skin: After topical application: Dermatitis, allergic Biochemical: Metabolism (intermediary): Other proteins Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	TOLED5 190,231,2009
skin/mouse	lowest published toxic dose: 7.2 mg/kg/6D- intermittent	Skin: After topical application: Cutaneous sensitization (experimental)	FCTOD7 48,1704,2010
skin/mouse	lowest published toxic dose: 12 mg/kg/8D- intermittent	Blood: Other changes Skin: After topical application: Cutaneous sensitization (experimental)	TXCYAC 279,85,2011
skin/mouse	lowest published toxic dose: 15 mg/kg/3D- intermittent	Skin: After topical application: Cutaneous sensitization (experimental) Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	TXAPA9 184,46,2002
skin/mouse	lowest published toxic dose: 800 mg/kg/4D- intermittent	Immunological Including Allergic: Increased immune response Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	EJPHAZ 446,195,2002
skin/mouse	lowest published toxic dose: 240 mg/kg/28D- intermittent	Immunological Including Allergic: Increase in humoral response	TOSCF2 94,108,2006
skin/mouse	lowest published toxic dose: 0.03 mL/kg/3D- intermittent	Skin: After topical application: Cutaneous sensitization (experimental)	TOLED5 177,1,2008
skin/mouse	lowest published toxic dose: 1.8 ul/kg/3D- intermittent	Skin: After topical application: Cutaneous sensitization (experimental)	TOLED5 180,1,2008
skin/mouse	lowest published toxic dose: 18 ul/kg/17D- intermittent	Skin: After topical application: Cutaneous sensitization (experimental)	TOLED5 180,1,2008
skin/mouse	lowest published toxic dose: 18.2 ul/kg/31D- intermittent	Skin: After topical application: Cutaneous sensitization (experimental) Immunological Including Allergic: Increased immune response	TOLED5 180,1,2008
skin/mouse	lowest published toxic dose: 1.7 mg/kg/17D- intermittent	Immunological Including Allergic: Increase in cellular immune response Immunological Including Allergic: Increase in humoral response	TOLED5 181,163,2008
skin/mouse	lowest published toxic dose: 90 mg/kg/3D- intermittent	Immunological Including Allergic: Increase in humoral response Biochemical: Metabolism (intermediary): Other proteins Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	TXCYAC 250,116,2008
skin/mouse	lowest published toxic dose: 4.8 mg/kg/8D- intermittent	Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	TOXID9 -,11,2009

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.005 ppm;short term exposure limit 0.02 ppm (sen)	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Sufficient Evidence	IMEMDT 39,287,1986
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Sufficient Evidence	IMEMDT 71,865,1999
International Agency for Research on Cancer (IARC)	Cancer Review:Human No Adequate Data	IMEMDT 39,287,1986
International Agency for Research on Cancer (IARC)	Cancer Review:Human Inadequate Evidence	IMEMDT 71,865,1999
International Agency for Research on Cancer (IARC)	Cancer Review:Group 2B	IMEMDT 71,865,1999
TOXICOLOGY REVIEW		MUREAV 539,77,2003
TOXICOLOGY REVIEW		AOHYA3 17,143,1974
TOXICOLOGY REVIEW		JJOMDZ 15,808,1973
TOXICOLOGY REVIEW		CMTVAS 10(3),49,1973
TOXICOLOGY REVIEW		MUREAV 567,227,2004
TOXICOLOGY REVIEW		DIMON* 46,551,2000
TOXICOLOGY REVIEW		ENTOX* -,204,2005
TOXICOLOGY REVIEW		MUREAV 584,1,2005
TOXICOLOGY REVIEW		MUREAV 681,93,2009

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD	air-ceiling concentration 0.02 ppm (0.14 mg/m³)	DTLVS* 3,260,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypt	time-weighted average 0.02 ppm (0.14 mg/m³), JAN1993
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.02 mg(NCO)/m³, short term exposure limit 0.07 mg(NCO)/m³, JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.005 ppm (0.035 mg/m³);KZW 0.02 ppm (0.14 mg/m³), sen, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 0.005 ppm (0.037 mg/m³), MAR2002
Occupational Exposure Limit-BELGIUM	short term exposure limit 0.02 ppm (0.14 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.005 ppm (0.035 mg/m³), carc, MAY2011
Occupational Exposure Limit-HUNGARY	ceiling concentration 0.035 mg/m³, Carcinogen, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 0.005 ppm (0.04 mg/m³), short term exposure limit 0.01 ppm (0.07 mg/m³), sen, NOV2011
Occupational Exposure Limit-JAPAN	Occupational Exposure Limit 0.005 ppm, skin, 2B carc, s1 sen, MAY2012
Occupational Exposure Limit-JAPAN	ceiling concentration 0.02 ppm (0.14 mg/m³), MAY2012
Occupational Exposure Limit-KOREA	time-weighted average 0.005 ppm (0.04 mg/m³), short term exposure limit 0.02 ppm (0.15 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 0.02 ppm (0.14 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.02 mg(NCO)/m³; short term exposure limit 0.07 mg(NCO)/m³, sen, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 0.005 ppm (0.035 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 0,005 ppm (0,036 mg/m³); short term exposure limit 0,02 ppm (0,014 mg/m³), JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 0.035 mg/m³, MAC(short term exposure limit) 0.070 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	short term exposure limit 0.05 mg/m³, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 0.002 ppm (0.014 mg/m³), Carcinogen, Sen, JUN2005
Occupational Exposure Limit-SWEDEN	ceiling concentration 0.005 ppm (0.04 mg/m³), JUN2005
Occupational Exposure Limit-SWITZERLAND	ceiling concentration 0.02 mg(NCO)/m³, skin, sen, JAN2011
Occupational Exposure Limit-THAILAND	time-weighted average 0.02 ppm (0.14 mg/m³), JAN1993
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 0.04 mg/m³, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 0.02 ppm (0.14 mg/m³), JAN1993
Occupational Exposure Limit-TURKEY	time-weighted average 0.02 ppm (0.14 mg/m³), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	ceiling concentration 0.02 ppm (0.14 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	ceiling concentration 0.02 ppm (0.14 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	ceiling concentration 0.02 ppm (0.14 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	ceiling concentration 0.02 ppm (0.14 mg/m³)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TOLUENE DIISOCYANATE-air	Carcinogen lowest feasible conc	NIOSH* DHHS#92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 73390; Number of Industries 19; Total Number of Facilities 838; Number of Occupations 30; Total Number of Employees Exposed 10921; Total Number of Female Employees Exposed 545
National Occupational Hazard Survey 1974	Hazard Code 73390; Number of Industries 47; Total Number of Facilities 2310; Number of Occupations 54; Total Number of Employees Exposed 26654

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Isocyanates, monomeric, 5521
NIOSH Analytical Method, 1994: Toluene-2,4-diisocyanate, 2535
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
OSHA ANALYTICAL METHOD #18, SUPERSEDED BY #42
OSHA ANALYTICAL METHOD #33

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Page last reviewed:March 7, 2014
Page last updated:February 6, 2017
Content source:
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