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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzene, 1,2,3-trimethyl-

RTECS #

DC3300000

CAS #

526-73-8

Updated

July 2013

Molecular Weight

120.21

Molecular Formula

C9H12

Synonyms

1,2,3-Trimethylbenzene
1,2,3-Trimethylbenzene (ACGIH)
Hemimellitene
Hemimellitol

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium5 µg/plate (-enzymatic activation step)MUREAV 412,299,1998
sister chromatid exchangeintraperitoneal/mouse730 mg/kgMUREAV 412,299,1998

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published lethal dose: 10 mL/kgLung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Hemorrhage		AMIHAB 19,403,1959

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 100 ppm/6H/20D- intermittentBehavioral: Alteration of classical conditioningNRTXDN 22,79,2001
inhalation/rat lowest published toxic concentration: 20 mg/m3/16W- continuousKidney, Ureter, and Bladder: Other changes in urine compositionVCVGH* -,176,1990

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-DENMARKtime-weighted average 20 ppm (100 mg/m3), MAY2011
Occupational Exposure Limit-ECtime-weighted average 100 mg/m3 (20 ppm), JUN2000
Occupational Exposure Limit-FRANCEVLE 20 ppm (100 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 20 ppm (100 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 100 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 20 ppm (100 mg/m3), NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 25 ppm (120 mg/m3), MAY2012
Occupational Exposure Limit-MEXICOtime-weighted average 25 ppm (125 mg/m3);short term exposure limit 35 ppm (170 mg/m3), 2004
Occupational Exposure Limit-NORWAYtime-weighted average 20 ppm (100 mg/m3), JAN1999
Occupational Exposure Limit-SWEDENtime-weighted average 25 ppm (120 mg/m3);short term exposure limit 35 ppm (170 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 20 ppm (100 mg/m3), KZG-week 40 ppm (200 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 100 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 25 ppm (125 mg/m3), OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code T1997; Number of Industries 2; Total Number of Facilities 13; Number of Occupations 2; Total Number of Employees Exposed 279

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

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