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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzenethiol

RTECS #

DC0525000

CAS #

108-98-5

Updated

September 201

Molecular Weight

110.18

Molecular Formula

C6H6S

Synonyms

Mercaptobenzene
Phenol, thio-
Phenyl mercaptan
Phenyl mercaptan (ACGIH:OSHA)
RCRA waste number P014
Thiofenol (Czech)
Thiophenol
USAF XR-19

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 108 mg severeAIHAAP 19,171,1958

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 500 mg/kg (6-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Other effects to embryo or fetus		NTIS** PB94-155009
oral/rat 18 mg/kg (multigenerations)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)NTIS** #PB96-211735
oral/rat 18 mg/kg (multigenerations)Reproductive: Specific developmental abnormalities: Urogenital systemNTIS** #PB96-211735
oral/rat 315 mg/kg (7D male/7D prior to copulation/21D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)NTIS** #PB96-211735
oral/rat 5145 mg/kg (21W prior to copulation)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)NTIS** #PB96-211735
oral/rat 9 mg/kg (multigenerations)Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)		NTIS** #PB96-211735
oral/rat 9 mg/kg (multigenerations)Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Urogenital system		NTIS** #PB96-211735
oral/rat 500 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)NTIS** #PB94-155009
oral/rat 500 mg/kg (6-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)		NTIS** #PB94-155009
oral/rat 500 mg/kg (6-15D pregnant)Reproductive: Other effects to embryo or fetusNTIS** #PB94-155009
oral/rat 245 mg/kg (7D prior to copulation)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)		HPV134 -,-,2004
oral/rat 200 mg/kg (6-15D pregnant)Reproductive: Other effects on femaleHPV134 -,-,2004
oral/rat 350 mg/kg (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)		HPV134 -,-,2004
oral/rabbit 140 mg/kg (6-19D pregnant)Reproductive: Other effects on femaleHPV134 -,-,2004

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 0.6 mg/m3/1MLung, Thorax, or Respiration: Structural or functional change in trachea or bronchiTOVEFN (6),38,1995
inhalation/mouse lethal concentration (50 percent kill): 25 ppmHPV134 -,-,2004
inhalation/mouse lethal concentration (50 percent kill): 28 ppm/4HLung, Thorax, or Respiration: Respiratory stimulation

Behavioral: Somnolence (general depressed activity)

Eye: Lacrimation		AIHAAP 19,171,1958
inhalation/mouse lethal concentration (50 percent kill): 514 mg/m3/2HTOVEFN (6),38,1995
inhalation/rat lethal concentration (50 percent kill): 634 mg/m3/4HTOVEFN (6),38,1995
inhalation/rat lowest published toxic concentration: 9.4 mg/m3/4HBehavioral: Alteration of classical conditioning

Liver: Liver function tests impaired

Kidney, Ureter, and Bladder: Renal function tests depressed		TOVEFN (6),38,1995
inhalation/rat lowest published toxic concentration: 9.4 mg/m3/4HBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: TransaminasesTOVEFN (6),38,1995
inhalation/rat lowest published toxic concentration: 2.4 mg/m3/4HLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Other changes		TOVEFN (6),38,1995
inhalation/rat lethal concentration (50 percent kill): 33 ppm/4HLung, Thorax, or Respiration: Respiratory stimulation

Behavioral: Somnolence (general depressed activity)

Eye: Lacrimation		AIHAAP 19,171,1958
intraperitoneal/mouse lethal dose (50 percent kill): 25 mg/kgNTIS** AD277-689
intraperitoneal/rat lethal dose (50 percent kill): 9800 µg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression		AIHAAP 19,171,1958
intraperitoneal/rat lethal dose (50 percent kill): 9.8 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Coma		HPV134 -,-,2004
intraperitoneal/rat lethal dose (50 percent kill): 39 mg/kgBehavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)

Behavioral: Coma		TOVEFN (6),38,1995
intraperitoneal/rat lethal dose (50 percent kill): 39 mg/kgLung, Thorax, or Respiration: Respiratory depressionTOVEFN (6),38,1995
oral/mouse lethal dose (50 percent kill): 267 mg/kgBehavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea		NTIS** OTS0557376
oral/mouse lethal dose (50 percent kill): 266 mg/kgGISAAA 1,7,1994
oral/rat lethal dose (50 percent kill): 200 mg/kgTOVEFN (6),38,1995
oral/rat lethal dose (16 percent kill): 140 mg/kgBehavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)

Behavioral: Coma		TOVEFN (6),38,1995
oral/rat lethal dose (16 percent kill): 140 mg/kgLung, Thorax, or Respiration: Respiratory depressionTOVEFN (6),38,1995
oral/rat lethal dose (50 percent kill): 355 mg/kgBehavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)

Behavioral: Coma		TOVEFN (6),38,1995
oral/rat lethal dose (50 percent kill): 355 mg/kgLung, Thorax, or Respiration: Respiratory depressionTOVEFN (6),38,1995
oral/rat lethal dose (50 percent kill): 46200 µg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression		AIHAAP 19,171,1958
oral/rat lethal dose (50 percent kill): 46.2 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression		HPV134 -,-,2004
oral/rat lowest published lethal dose: 302 mg/kgTOVEFN (6),38,1995
oral/wild bird lethal dose (50 percent kill): 24 mg/kgTXAPA9 21,315,1972
skin/rabbit lethal dose (50 percent kill): 134 mg/kgBehavioral: Muscle weakness

Behavioral: Ataxia

Lung, Thorax, or Respiration: Cyanosis		AIHAAP 19,171,1958
skin/rat lethal dose (50 percent kill): 300 mg/kgBehavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression

Skin: After topical application: Primary irritation		AIHAAP 19,171,1958
skin/rat lethal dose (50 percent kill): 300 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Coma		HPV134 -,-,2004

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rabbit lowest published toxic dose: 420 mg/kg/14D- intermittentBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		NTIS** #PB94-201183
oral/rabbit lowest published toxic dose: 700 mg/kg/14D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTIS** #PB94-155009
oral/rabbit lowest published toxic dose: 80 mg/kg/8D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldHPV134 -,-,2004
oral/rat lowest published toxic dose: 200 mg/kg/10D- intermittentBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		NTIS** #PB94-155009
oral/rat lowest published toxic dose: 500 mg/kg/10D- intermittentBehavioral: Fluid intake

Liver: Changes in liver weight		NTIS** #PB94-155009
oral/rat lowest published toxic dose: 27 mg/kg/30D- intermittentCardiac: EKG changes not diagnostic of above

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase		GISAAA 1,7,1994
oral/rat lowest published toxic dose: 1.825 mg/kg/26W- intermittentBehavioral: Change in motor activity (specific assay)

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases		GISAAA 1,7,1994
oral/rat lowest published toxic dose: 18.25 mg/kg/26W- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: PhosphatasesGISAAA 1,7,1994
oral/rat lowest published toxic dose: 5145 mg/kg/21W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTIS** #PB96-211735
oral/rat lowest published toxic dose: 1323 mg/kg/21W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight		NTIS** #PB96-211735
oral/rat lowest published toxic dose: 1323 mg/kg/21W- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in kidney weight		NTIS** #PB96-211735
oral/rat lowest published toxic dose: 1323 mg/kg/21W- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)		NTIS** #PB96-211735
oral/rat lowest published toxic dose: 2646 mg/kg/21W- intermittentLiver: Other changes

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)		NTIS** #PB96-211735
skin/rabbit lowest published toxic dose: 500 µL/kg/5D- intermittentSkin: After systemic exposure: Dermatitis, otherNTIS** OTS0557376

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.1 ppm (skin)DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWREPTED 25,192,2008

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.5 ppm (2.3 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.4 ppm (2 mg/m3);KZW 0.8 ppm (4 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.5 ppm (2.3 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.5 ppm (2.3 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDshort term exposure limit 0.5 ppm (2.3 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 0.5 ppm (2 mg/m3), FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 0.5 ppm (2.3 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.5 ppm (2 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.5 ppm (2 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.5 ppm (2.3 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.5 ppm (2 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0,5 ppm (2,3 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.2 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 0.5 ppm (2.3 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 2 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BENZENETHIOL-airceiling concentration 0.1 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code X4092; Number of Industries 1; Total Number of Facilities 24; Number of Occupations 2; Total Number of Employees Exposed 879; Total Number of Female Employees Exposed 187

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database

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