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Registry of Toxic Effects of Chemical Substances (RTECS)

Biphenyl, mixed with biphenyl oxide (3:7)

RTECS #

DV1500000

CAS #

8004-13-5

Updated

July 2013

Molecular Weight

324.44

Molecular Formula

C12H10O·C12H10

Synonyms

1,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene)
Biphenyl-diphenyl ether mixture
Dinil
Dinyl
Diphenyl mixed with diphenyl oxide
Diphyl
Dowtherm
Dowtherm A
Phenyl ether-biphenyl mixture (OSHA)
Phenyl ether-diphenyl mixture

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg/24H mild28ZPAK -,271,1972
skin /rabbit 500 mg/24H mild28ZPAK -,271,1972

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 3 ppmOlfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Other changes		28ZRAQ -,204,1960
inhalation/human lowest published toxic concentration: 26.8 mg/m3Eye: Conjunctiva irritation

Behavioral: Headache

Lung, Thorax, or Respiration: Cough		VCVGK* -,308,1984
oral/guinea pig lethal dose (50 percent kill): 3 gm/kg85GMAT -,61,1982
oral/mouse lethal dose (50 percent kill): 3200 mg/kgVCVGK* -,308,1984
oral/rabbit lethal dose (50 percent kill): 4200 mg/kgVCVGK* -,308,1984
oral/rat lethal dose (50 percent kill): 2460 mg/kg28ZPAK -,271,1972

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 200 µg/m3/24H/70D- continuousBehavioral: Muscle contraction or spasticity

Kidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Metabolism (intermediary): Porphyrin including bile pigments		GISAAA 26(5),3,1961
inhalation/rat lowest published toxic concentration: 20 mg/m3/4H/122D- intermittentLung, Thorax, or Respiration: Emphysema

Blood: Change in clotting factors

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		VCVGK* -,308,1994
inhalation/rat lowest published toxic concentration: 10 mg/m3/70D- continuousBehavioral: Muscle weakness

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Metabolism (intermediary): Porphyrin including bile pigments		VCVGK* -,308,1994
oral/rat lowest published toxic dose: 130 mg/kg/26W- intermittentKidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		ATORAI -,1,1948

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWATORAI -,-,1948

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 1 ppm (7 mg/m3) (vapor)DTLVS* 3,206,1971
Occupational Exposure Limit-MEXICOtime-weighted average 1 ppm (7 mg/m3) (vapor), 2004
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDceiling concentration 1 ppm (7 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 7 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 1 ppm (7 mg/m3), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 1 ppm (7 mg/m3), vaporCFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 1 ppm (7 mg/m3), vaporCFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 1 ppm (7 mg/m3), vaporCFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 1 ppm (7 mg/m3), vaporCFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHENYL ETHER-BIPHENYL MIXTURE, vapor-air10H time-weighted average 1 ppmNIOSH* DHHS#92-100,1992

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Phenyl ether-diphenyl mixture, 2013

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