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Registry of Toxic Effects of Chemical Substances (RTECS)

Biphenyl, 4-nitro-

RTECS #

DV5600000

CAS #

92-93-3

Updated

September 201

Molecular Weight

199.22

Molecular Formula

C12H9NO2

Synonyms

4-Nitrobiphenyl
4-Nitrodiphenyl
4-Nitrodiphenyl (ACGIH)
4-Phenyl-nitrobenzene
PNB
p-Nitrobiphenyl
p-Nitrodiphenyl
p-Phenyl-nitrobenzene

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
body fluid assaySalmonella typhimurium/rat400 mg/kg/4DPNASA6 72,4607,1975
DNA adduct/Escherichia coli50 µmol/LMUREAV 89,95,1981
DNA adductoral/Dog60 µmol/kgEVHPAZ 49,125,1983
DNA Damageother cell types/human60 µmol/LEMMUEG 38,1,2001
DNA Damageliver/rat300 µmol/LSinJF# 26OCT1982
DNA repair/Escherichia coli250 mg/LJJIND8 62,873,1979
host-mediated assaySalmonella typhimurium/rat750 mg/kg/3DAJCNAC 30,1921,1977
morphological transformkidney/hamster80 µg/LBJCAAI 37,873,1978
morphological transformembryo/hamster100 µg/LIJCNAW 19,642,1977
mutation in microorganisms/Salmonella typhimurium20 µg/plate/48H (+/-enzymatic activation step)MUREAV 491,195,2001
mutation in microorganismslymphocyte/mouse77600 µg/L (+enzymatic activation step)MUREAV 97,49,1982
mutation in microorganisms/Bacillus subtilis50 mmol/L (-enzymatic activation step)EXPEAM 39,530,1983
mutation in microorganisms/Salmonella typhimurium40 µg/plate (+enzymatic activation step)MUREAV 172,37,1986
mutation in microorganisms/Salmonella typhimurium10 µg/plate (-enzymatic activation step)ESKGA2 29,63,1983
sister chromatid exchangeintraperitoneal/hamster100 mg/kgMUREAV 113,33,1983
sister chromatid exchangeovary/hamster10 µmol/LENMUDM 4,1,1982
sister chromatid exchangeoral/hamster125 mg/kgMUREAV 113,33,1983
Unscheduled DNA Synthesisliver/rat100 µmol/LENMUDM 3,11,1981

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published toxic dose: 7000 mg/kg/2Y- intermittentTumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors		JAMAAP 172,1611,1960
oral/Dog toxic dose: 7000 mg/kg/3Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors		IMSUAI 27,634,1958

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 347 mg/kgJJIND8 62,911,1979
oral/rabbit lethal dose (50 percent kill): 1970 mg/kgBehavioral: Coma

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		JIHTAB 29,1,1947
oral/rat lethal dose (50 percent kill): 2230 mg/kgBehavioral: Coma

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		JIHTAB 29,1,1947

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Control as low as possible (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Suspected human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 4,113,1974
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 4,113,1974
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,56,1987
TOXICOLOGY REVIEWADCSAJ 13,271,1970
TOXICOLOGY REVIEWMUREAV 567,347,2004
TOXICOLOGY REVIEWMUREAV 584,1,2005

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARDHUMAN CARCINOGENDTLWS* 3,24,1973
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIACarcinogen, JUL2008
Occupational Exposure Limit-BELGIUMSkin, MAR2002
Occupational Exposure Limit-KOREAcarcinogen, skin, 2006
Occupational Exposure Limit-NEW ZEALANDskin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.01 mg/m3, JAN1999
Occupational Exposure Limit-SWEDENGroup A Carcinogen, JUN2005
Occupational Exposure Limit-SWITZERLANDcarc 2, JAN2011
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)see Code of Federal Regulations (CFR) 29,1926.1103CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA)-cancer suspect agentCFRGBR 29,1910.1003,1987

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 4-NITROBIPHENYL-airCarcinogen use 29 Code of Federal Regulations (CFR) 1910.1003NIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: N crassa-aneuploidy; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: Host-mediated assay; E coli polA without S9
EPA GENETOX PROGRAM 1988, Positive: SHE-clonal assay; Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database

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