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Registry of Toxic Effects of Chemical Substances (RTECS)

Bromine

RTECS #

EF9100000

CAS #

7726-95-6

Updated

September 201

Molecular Weight

159.82

Molecular Formula

Br2

Synonyms

Brom (German)
Brome (French)
Bromine (ACGIH:OSHA)
Bromo (Italian)
Broom (Dutch)
Dibromine

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/cat Lowest published lethal concentration: 1200 mg/m3VCVN5* -,389,1989
inhalation/cat Lowest published lethal concentration: 150 mg/m3/7HLung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Dyspnea		VCVN5* -,389,1989
inhalation/guinea pig Lowest published lethal concentration: 150 mg/m3/7HLung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Dyspnea		VCVN5* -,389,1989
inhalation/guinea pig Lowest published lethal concentration: 1200 mg/m3VCVN5* -,389,1989
inhalation/human Lowest published lethal concentration: 1000 ppm34ZIAG -,645,1969
inhalation/human lowest published toxic concentration: 13 mg/m3Lung, Thorax, or Respiration: CoughVCVN5* -,390,1989
inhalation/human lowest published toxic concentration: 11 mg/m3Lung, Thorax, or Respiration: Respiratory depressionVCVN5* -,390,1989
inhalation/human Lowest published lethal concentration: 220 mg/m3VCVN5* -,390,1989
inhalation/mammal (species unspecified) lowest published toxic concentration: 50 mg/m3Cardiac: Other changes

Endocrine: Other changes		VCVN5* -,389,1989
inhalation/mammal (species unspecified) lowest published toxic concentration: 100 mg/m3Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)VCVN5* -,389,1989
inhalation/mouse lethal concentration (50 percent kill): 2900 mg/m3VCVN5* -,389,1989
inhalation/mouse lethal concentration (50 percent kill): 750 ppm/9MAIHAAP 39,129,1978
inhalation/rabbit Lowest published lethal concentration: 180 ppm/6.5HHBTXAC 1,324,1955
inhalation/rabbit Lowest published lethal concentration: 1200 mg/m3VCVN5* -,389,1989
inhalation/rabbit Lowest published lethal concentration: 150 mg/m3/7HLung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Dyspnea		VCVN5* -,389,1989
inhalation/rat lethal concentration (50 percent kill): 2700 mg/m3Lung, Thorax, or Respiration: Other changesGTPZAB 20(3),36,1976
inhalation/rat lethal concentration (50 percent kill): 2700 mg/m3VCVN5* -,389,1989
inhalation/rat lowest published toxic concentration: 10 mg/m3/4HOlfaction: Change in sensation of smell

Lung, Thorax, or Respiration: Respiratory depression		VCVN5* -,389,1989
inhalation/rat lowest published toxic concentration: 10 mg/m3/4HBehavioral: Alteration of classical conditioningTPKVAL 14,63,1975
inhalation/rat lowest published toxic concentration: 500 mg/m3/4HLung, Thorax, or Respiration: Structural or functional change in trachea or bronchiTPKVAL 14,63,1975
inhalation/rat lowest published toxic concentration: 100 mg/m3/4HLung, Thorax, or Respiration: Other changesTPKVAL 14,63,1975
inhalation/rat lowest published toxic concentration: 200 mg/m3/4HOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi		TPKVAL 14,63,1975
oral/guinea pig lethal dose (50 percent kill): 5500 mg/kgVCVN5* -,389,1989
oral/human lowest published lethal dose: 14 mg/kg34ZIAG -,645,1969
oral/mammal (species unspecified) lethal dose (50 percent kill): 440 mg/kgGISAAA 39(4),86,1974
oral/mouse lethal dose (50 percent kill): 3100 mg/kgVCVN5* -,389,1989
oral/rabbit lethal dose (50 percent kill): 2500 mg/kgVCVN5* -,389,1989
oral/rat lethal dose (50 percent kill): 1700 mg/kgVCVN5* -,389,1989
skin/pig lowest published toxic dose: 0.06 mL/kgSkin: After systemic exposure: Dermatitis, irritative

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation		TOLED5 182,69,2008

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rabbit lowest published toxic concentration: 12.4 mg/m3/24H/17W- continuousLung, Thorax, or Respiration: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes		VCVN5* -,390,1989
inhalation/rabbit lowest published toxic concentration: 1.4 mg/m3/24H/17W- continuousOlfaction: Other olfaction effectsVCVN5* -,390,1989
inhalation/rat lowest published toxic concentration: 1.4 mg/m3/24H/17W- continuousOlfaction: Other olfaction effectsVCVN5* -,390,1989
inhalation/rat lowest published toxic concentration: 1400 µg/m3/17W- intermittentLung, Thorax, or Respiration: Respiratory depression

Endocrine: Evidence of thyroid hypofunction

Endocrine: Changes in thyroid weight		GTPZAB 20(3),36,1976
inhalation/rat lowest published toxic concentration: 12.4 mg/m3/24H/17W- continuousCardiac: Other changes

Endocrine: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		VCVN5* -,390,1989
oral/rat lowest published toxic dose: 3094 mg/kg/13W- intermittentEndocrine: Hyperglycemia

Skin and Appendages: Other: Hair

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase		VCVN5* -,390,1989
unreported route/rat lowest published toxic dose: 3375 mg/kg/15D- intermittentEndocrine: EstrogenicVCVN5* -,390,1989

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.1 ppm;short term exposure limit 0.2 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWKOTTAM 11,1300,1975
TOXICOLOGY REVIEWFOREAE 7,313,1942
TOXICOLOGY REVIEWCLCHAU 19,361,1973
TOXICOLOGY REVIEWENTOX* -,342,2005
TOXICOLOGY REVIEWHUTOX* -,661,1996

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,298,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.1 ppm (0.7 mg/m3)DTLVS* 3,27,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.1 ppm (0.7 mg/m3), JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 ppm (0.66 mg/m3), short term exposure limit 0.3 ppm (2 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.1 ppm (0.7 mg/m3);KZW 0.1 ppm (0.7 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 ppm (0.67 mg/m3), MAR2002
Occupational Exposure Limit-BELGIUMshort term exposure limit 0.2 ppm (1.3 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.1 ppm (0.7 mg/m3), MAY2011
Occupational Exposure Limit-ECtime-weighted average 0.7 mg/m3 (0.1 ppm), FEB2006
Occupational Exposure Limit-FINLANDshort term exposure limit 0.1 ppm (0.66 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVLE 0.1 ppm (0.7 mg/m3), FEB2006
Occupational Exposure Limit-HUNGARYtime-weighted average 0.7 mg/m3, short term exposure limit 0.7 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 0.1 ppm (0.7 mg/m3), NOV2011
Occupational Exposure Limit-INDIAtime-weighted average 0.1 ppm (0.7 mg/m3), short term exposure limit 0.3 ppm (2 mg/m3), JAN1993
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.1 ppm (0.65 mg/m3), MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 0.1 ppm (0.7 mg/m3), short term exposure limit 0.3 ppm (2 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.1 ppm (0.7 mg/m3);short term exposure limit 0.3 ppm (2 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 ppm (0.66 mg/m3); short term exposure limit 0.3 ppm (2 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.1 ppm (0.7 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0.1 ppm (0.65 mg/m3); short term exposure limit 0.2 ppm (1.3 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.7 mg/m3, MAC(short term exposure limit) 2 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.5 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.1 ppm (0.7 mg/m3);short term exposure limit 0.3 ppm (2 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDceiling concentration 0.1 ppm (0.7 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.7 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.1 ppm (0.7 mg/m3), JAN1999
Occupational Exposure Limit-TURKEYtime-weighted average 0.1 ppm (0.7 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.1 ppm (0.66 mg/m3);short term exposure limit 0.2 ppm (1.3 mg/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.1 ppm (0.7 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.1 ppm (0.7 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.1 ppm (0.7 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.1 ppm (0.7 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BROMINE-air10H time-weighted average 0.1 ppm;short term exposure limit 0.3 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 13100; Number of Industries 40; Total Number of Facilities 1679; Number of Occupations 55; Total Number of Employees Exposed 62214; Total Number of Female Employees Exposed 10780
National Occupational Hazard Survey 1974Hazard Code 13100; Number of Industries 17; Total Number of Facilities 583; Number of Occupations 16; Total Number of Employees Exposed 23977

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Bromine and chlorine, 6011
OSHA ANALYTICAL METHOD #ID-108

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