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Registry of Toxic Effects of Chemical Substances (RTECS)

1,3-Butadiene

RTECS #

EI9275000

CAS #

106-99-0; 130983-70-9

Updated

December 2013

Molecular Weight

54.10

Molecular Formula

C4H6

Synonyms

1,3-Butadiene (ACGIH:OSHA)
alpha,gamma-Butadiene
Biethylene
Bivinyl
Buta-1,3-dieen (Dutch)
Buta-1,3-dien (German)
Buta-1,3-diene
Butadieen (Dutch)
Butadien (Polish)
Butadiene
Butadiene (OSHA)
Butadiene-1,3
Divinyl
Erythrene
NCI-C50602
Pyrrolylene
Vinylethylene

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisinhalation/mouse625 ppm/6H/10D- intermittentENMUDM 9,235,1987
Cytogenetic Analysisinhalation/mouse1250 ppm/5D/2W- intermittentTOXID9 66,71,2002
Cytogenetic Analysisinhalation/rat1250 ppm/5D/2W- intermittentTOXID9 66,71,2002
Cytogenetic Analysislung/hamster20 pph/6H (+/-enzymatic activation step)MUREAV 652,122,2008
DNA adductinhalation/rat20 ppm/6HCBINA8 147,195,2004
DNA adductinhalation/mouse20 ppm/6HCBINA8 147,195,2004
DNA adductinhalation/rat1 ppm/5DCBINA8 147,195,2004
DNA adductinhalation/mouse1 ppm/5DCBINA8 147,195,2004
DNA adductinhalation/rat10 mg/kg/6HCBINA8 148,69,2004
DNA adductinhalation/mouse21 mg/kg/6HCBINA8 148,69,2004
DNA adductinhalation/mouse20 ppmMUREAV 577S,1,2005
DNA adductinhalation/mouse200 ppm/6H/5D-continuousMUREAV 397,3,1998
DNA Damageinhalation/mouse125 ppm/6H-continuousMUREAV 397,67,1998
DNA Damageinhalation/mouse20 ppm/1Y- intermittentCBINA8 135-136,373,2001
DNA Damageinhalation/rat1250 ppm/2W- intermittentEMMUEG 43,75,2004
DNA Damagelung/mouse500 µg/L/6H/28D- intermittentMUREAV 608,49,2006
DNA Damageinhalation/mouse625 ppm/2W- intermittentCRTOEC 21,1163,2008
DNA Damageother cell types/human100 ppm/30MTXAPA9 245,219,2010
DNA repairlung/mouse500 µg/L/6H/28D- intermittentMUREAV 608,49,2006
Dominant Lethal Testinhalation/mouse1250 ppm/6H/10W- intermittentMUREAV 309,295,1994
heritable translocation testinhalation/mouse500 ppm/6H/5D-continuousMUREAV 397,85,1998
micronucleus testinhalation/mouse500 ppm/5DMUREAV 491,81,2001
micronucleus testinhalation/mouse6250 ppb/6H/13W- intermittentMUREAV 209,171,1988
micronucleus testlung/mouse500 µg/L/6H/28D- intermittentMUREAV 608,49,2006
micronucleus testinhalation/mouse50 ppm/5D- intermittentHPV182 -,-,1999
mutation in mammalian somatic cellslymphocyte/mouse20 pphENMUDM 8(Suppl 6),75,1986
mutation in mammalian somatic cellsinhalation/mouse625 ppm/6H/2W- intermittentCRNGDP 15,719,1994
mutation in microorganisms/Salmonella typhimurium20 pph/20H-continuous (+enzymatic activation step)TOERD9 3,131,1981
mutation in microorganisms/Salmonella typhimurium2 pph (-enzymatic activation step)TOLED5 6,125,1980
sister chromatid exchangelymphocyte/human500 µmol/LMUREAV 261,117,1991
sister chromatid exchangeinhalation/mouse6250 ppb/6H/10D- intermittentENMUDM 9,235,1987
sister chromatid exchangeovary/hamster25 µmol/LMUREAV 263,47,1991
specific locus testinhalation/mouse3 ppm/14D- intermittentCBINA8 135-136,343,2001
specific locus testinhalation/mouse500 ppm/6H/5D-continuousMUREAV 309,307,1994
specific locus testinhalation/mouse1250 ppm/6H/2WEMMUEG 43,75,2004
specific locus testinhalation/rat1250 ppm/6H/2WEMMUEG 43,75,2004
specific locus testinhalation/human150 ppb/24YEMMUEG 41,140,2003
specific locus testinhalation/mouse20 ppm/7H/24DEMMUEG 42,106,2003
specific locus testinhalation/mouse20 ppm/6H/4WTOXID9 78,391,2004
specific locus testinhalation/mouse20 ppmMUREAV 577S,1,2005
specific locus testinhalation/mouse1250 ppm/2W- intermittentEMMUEG 43,75,2004
specific locus testinhalation/rat1250 ppm/2W- intermittentEMMUEG 43,75,2004
specific locus testinhalation/mouse1250 ppm/6H/2W- intermittentCBINA8 166,121,2007
specific locus testinhalation/rat62.5 ppm/6H/2W- intermittentCBINA8 166,121,2007
sperm morphologyinhalation/mouse130 ppm/6H/5D-continuousMUREAV 397,55,1998

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 8000 ppm/6H (6-15D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemEPASR* 8EHQ-0382-0441
inhalation/mouse 500 ppm/6H (5D male)Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material)		MUREAV 397,55,1998
inhalation/mouse 1000 ppm/6H (6-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)		EVHPAZ 86,79,1990
inhalation/mouse 1000 ppm/6H (6-15D pregnant)Reproductive: Maternal effects: Uterus, cervix, vaginaEVHPAZ 86,79,1990
inhalation/mouse 200 ppm (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)		HPV182 -,-,1999
inhalation/rat 200 ppm (6-15D pregnant)Reproductive: Other effects on femaleHPV182 -,-,1999

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/mouse toxic concentration (other than lowest): 625 ppm/6H/65W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Eye: Tumors

Cardiac: Tumors		EVHPAZ 86,27,1990
inhalation/mouse toxic concentration (other than lowest): 63 ppm/6H/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Vascular: Tumors

Liver: Tumors		NTPTR* NTP-TR-434,1993
inhalation/mouse toxic concentration (other than lowest): 200 ppm/6H/1Y- intermittentTumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains		CBINA8 135-136,373,2001
inhalation/mouse lowest published toxic concentration: 20 ppm/6H/1Y- intermittentTumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains		CBINA8 135-136,373,2001
inhalation/mouse toxic concentration (other than lowest): 216 mg/kg/8W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Other changes		CALEDQ 152,129,2000
inhalation/mouse lowest published toxic concentration: 22500 mg/kg/60W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Cardiac: Tumors

Lung, Thorax, or Respiration: Tumors		NTIS** PB85-179646/AS
inhalation/mouse lowest published toxic concentration: 22875 mg/kg/61W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Cardiac: Tumors

Lung, Thorax, or Respiration: Tumors		NTIS** PB85-179646/AS
inhalation/mouse lowest published toxic concentration: 45750 mg/kg/61W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Skin and Appendages: Tumors		NTIS** PB85-179646/AS
inhalation/mouse lowest published toxic concentration: 1730.4 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Lymphoma including Hodgkin's disease		NTIS** PB94-101631
inhalation/mouse lowest published toxic concentration: 540.75 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Lymphoma including Hodgkin's disease		NTIS** PB94-101631
inhalation/mouse lowest published toxic concentration: 625 ppm/6H/13W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Brain and Coverings: Tumors		TOPADD 33,307,2005
inhalation/mouse lowest published toxic concentration: 625 ppm/6H/13W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Cardiac: Tumors		CNREA8 50,6592,1990
inhalation/mouse toxic concentration (other than lowest): 200 ppm/40W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors		EVHPAZ 86,37,1990
inhalation/rat toxic concentration (other than lowest): 8000 ppm/6H/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Endocrine: Thyroid tumors

Skin and Appendages: Tumors		EVHPAZ 86,19,1990
inhalation/rat lowest published toxic concentration: 625 ppm/6H/61WTumorigenic: Carcinogenic by RTECS criteria

Cardiac: Tumors

Lung, Thorax, or Respiration: Tumors		NTPTR* NTP-TR-288,1984
inhalation/rat toxic concentration (other than lowest): 1000 ppm/6H/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors		AIHAAP 48,407,1987
inhalation/rat toxic concentration (other than lowest): 8000 ppm/6H/2Y- intermittentTumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors

Endocrine: Thyroid tumors		AIHAAP 48,407,1987
inhalation/rat toxic concentration (other than lowest): 8000 ppm/6H/15W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Endocrine: Tumors		EPASR* 8EHQ-0482-0370

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 2000 ppm/7HEye: Other eye effects

Behavioral: Hallucinations, distorted perceptions		JIHTAB 26,69,1944
inhalation/human lowest published toxic concentration: 8000 ppmEye: Visual field changes

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough		INMEAF 17,199,1948
inhalation/human lowest published toxic concentration: 1 pph/5MCardiac: Pulse rate decreased with fall in BP

Gastrointestinal: Changes in structure or function of salivary glands		VCVGH* -,60,1990
inhalation/mouse lowest published toxic concentration: 62.5 ppm/6HKidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)		TOXID9 72(Suppl 1),242,2003
inhalation/mouse lethal concentration (50 percent kill): 117000 ppm/4HENTOX* -,353,2005
inhalation/mouse lethal concentration (16 percent kill): 203000 mg/m3/2HVCVGH* -,60,1990
inhalation/mouse lethal concentration (84 percent kill): 375000 mg/m3/2HVCVGH* -,60,1990
inhalation/mouse lethal concentration (50 percent kill): 270000 mg/m3/2HHPV182 -,-,1999
inhalation/rabbit Lowest published lethal concentration: 250000 ppmVCVGH* -,60,1990
inhalation/rabbit lowest published toxic concentration: 200000 mg/m3/2HBlood: Changes in leukocyte (WBC) countVCVGH* -,60,1990
inhalation/rabbit Lowest published lethal concentration: 25 pph/23MEye: Mydriasis (pupilliary dilation)

Behavioral: Tremor

Behavioral: Muscle weakness		JIHTAB 26,69,1944
inhalation/rat lowest published toxic concentration: 62.5 ppm/6HKidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)		TOXID9 72(Suppl 1),242,2003
inhalation/rat lethal concentration (50 percent kill): 128000 ppm/4HENTOX* -,353,2005
inhalation/rat lethal concentration (50 percent kill): 285 gm/m3/4HBehavioral: General anesthetic

Lung, Thorax, or Respiration: Respiratory depression		RPTOAN 31,162,1968
inhalation/rat lethal concentration (16 percent kill): 175000 mg/m3/4HVCVGH* -,60,1990
inhalation/rat lethal concentration (84 percent kill): 460000 mg/m3/4HVCVGH* -,60,1990
inhalation/rat lethal concentration (50 percent kill): 285000 mg/m3/4HHPV182 -,-,1999
oral/mouse lethal dose (50 percent kill): 3210 mg/kgENTOX* -,353,2005
oral/rat lethal dose (50 percent kill): 5480 mg/kgENTOX* -,353,2005

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lowest published toxic concentration: 14800 mg/m3/7H/32W- intermittentKidney, Ureter, and Bladder: Other changesVCVGH* -,61,1990
inhalation/mouse lowest published toxic concentration: 500 ppm/9D- intermittentBlood: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		TIHEEC 21,15,2005
inhalation/mouse lowest published toxic concentration: 1000 ppm/20H/4D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainTIHEEC 21,15,2005
inhalation/mouse lowest published toxic concentration: 500 ppm/25H/5D- intermittentBlood: Other changesTIHEEC 21,15,2005
inhalation/mouse lowest published toxic concentration: 2500 ppm/9W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainHPV182 -,-,1999
inhalation/mouse lowest published toxic concentration: 1000 ppm/5D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)HPV182 -,-,1999
inhalation/mouse lowest published toxic concentration: 1250 ppm/6H/14W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-288,1984
inhalation/mouse lowest published toxic concentration: 1250 ppm/6H/6W- intermittentBlood: Normocytic anemia

Blood: Changes in bone marrow not included in above

Blood: Changes in erythrocyte (RBC) count		TXAPA9 85,450,1986
inhalation/mouse lowest published toxic concentration: 1250 ppm/6H/24W- intermittentBlood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count		TXAPA9 83,95,1986
inhalation/mouse lowest published toxic concentration: 8000 ppm/6H/15D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTPTR* NTP-TR-288,1984
inhalation/rabbit lowest published toxic concentration: 100 mg/m3/4H/17W- intermittentImmunological Including Allergic: Decrease in cellular immune response

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase		GISAAA 31(12),18,1966
inhalation/rat lowest published toxic concentration: 1000 ppm/6H/13W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight		FAATDF 32,1,1996
inhalation/rat lowest published toxic concentration: 1000 ppm/6H/1Y- intermittentLiver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		AIHAAP 48,407,1987
inhalation/rat lowest published toxic concentration: 2200 mg/m3/4H/17W- intermittentBlood: Luekopenia

Biochemical: Metabolism (intermediary): Lipids including transport

Biochemical: Metabolism (intermediary): Other proteins		GISAAA 31(12),18,1966
inhalation/rat lowest published toxic concentration: 8000 ppm/6H/2Y- intermittentBehavioral: Ataxia

Kidney, Ureter, and Bladder: Changes in bladder weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		NTIS** OTS0538010
inhalation/rat lowest published toxic concentration: 8000 ppm/14W- intermittentGastrointestinal: Changes in structure or function of salivary glandsHPV182 -,-,1999

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 2 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Suspected human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 39,155,1986
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 71,109,1999
International Agency for Research on Cancer (IARC)Cancer Review:Animal SUFFICENT EVIDENCEIMEMDT 54,237,1992
International Agency for Research on Cancer (IARC)Cancer Review:Human LIMITED EVIDENCIMEMDT 54,237,1992
International Agency for Research on Cancer (IARC)Cancer Review:Human Limited EvidenceIMEMDT 71,109,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 39,155,1986
International Agency for Research on Cancer (IARC)Cancer Review: Group 1IMEMDT 97,164,2008
International Agency for Research on Cancer (IARC)Cancer Review:Group 2AIMEMDT 71,109,1999
TOXICOLOGY REVIEWMUREAV 566,21,2004
TOXICOLOGY REVIEWCBINA8 135-136,65,2001
TOXICOLOGY REVIEWTOLED5 134,51,2002
TOXICOLOGY REVIEWTOLED5 134,31,2002
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWMUREAV 567,227,2004
TOXICOLOGY REVIEWMUREAV 567,109,2004
TOXICOLOGY REVIEWMUREAV 567,347,2004
TOXICOLOGY REVIEWMUTAEX 14,141,1999
TOXICOLOGY REVIEWMUREAV 566,209,2004
TOXICOLOGY REVIEWENTOX* -,353,2005
TOXICOLOGY REVIEWFCTOD7 44,1699,2006
TOXICOLOGY REVIEWMUREAV 627,10,2007
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWBCLPT* 96,131,2005
TOXICOLOGY REVIEWMUREAV 636,95,2007
TOXICOLOGY REVIEWJTEHD6 6,55,2003
TOXICOLOGY REVIEWREPTED 25,192,2008
TOXICOLOGY REVIEWMUREAV 544,273,2003
TOXICOLOGY REVIEWREPTED 23,428,2007
TOXICOLOGY REVIEWMUREAV 658,215,2008
TOXICOLOGY REVIEWMUREAV 659,202,2008
TOXICOLOGY REVIEWMUREAV 544,313,2003
TOXICOLOGY REVIEWMUREAV 544,339,2003
TOXICOLOGY REVIEWHUTOX* -,577,1996
TOXICOLOGY REVIEWMUREAV 608,136,2006
TOXICOLOGY REVIEWHTOPA* 1,501,2002
TOXICOLOGY REVIEWMUREAV 543,195,2003
TOXICOLOGY REVIEWMUREAV 681,3,2009
TOXICOLOGY REVIEWMUREAV 681,93,2009
TOXICOLOGY REVIEWMUREAV 590,1,2005
TOXICOLOGY REVIEWMUTAEX 22,161,2007
TOXICOLOGY REVIEWCBINA8 166,150,2007
TOXICOLOGY REVIEWTXAPA9 243,180,2010
TOXICOLOGY REVIEWMUREAV 705,107,2010
TOXICOLOGY REVIEWMUTAEX 26,33,2011
TOXICOLOGY REVIEWMUREAV 678,76,2009
TOXICOLOGY REVIEWMUREAV 727,1,2011
TOXICOLOGY REVIEWMUREAV 751,49,2012
TOXICOLOGY REVIEWFCTOD7 49,2921,2011
TOXICOLOGY REVIEWMUTAEX 28,485,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 1000 ppm (2200 mg/m3)DTLVS* 3,28,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 10 ppm (22 mg/m3), Carcinogen, JUL2008
Occupational Exposure Limit-AUSTRIATRK-TMW 5 ppm (11 mg/m3);KZW 20 ppm (44 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 2 ppm (4.5 mg/m3), Carcinogen, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 10 ppm (22 mg/m3), carc, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 1 ppm (2.2 mg/m3), NOV2011
Occupational Exposure Limit-HUNGARYceiling concentration 1 mg/m3, Carcinogen, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 10 ppm (20 mg/m3), carc, NOV2011
Occupational Exposure Limit-JAPAN1 carc, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 10 ppm (22 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 1000 ppm (2200 mg/m3);short term exposure limit 1250 ppm, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 10 ppm (22 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 1 ppm (2.2 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 2 ppm (4.4 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 10 mg/m3, short term exposure limit 40 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 100 mg/m3, MAR2004
Occupational Exposure Limit-SWEDENtime-weighted average 0.5 ppm (1 mg/m3);short term exposure limit 5 ppm (10 mg/m3), Carcinogen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 5 ppm (11 mg/m3), carc 2, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 46.2 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 1000 ppm (2200 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 1000 ppm (2200 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 10 ppm (22 mg/m3), carc, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 1000 ppm (2200 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 1000 ppm (2200 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 1000 ppm (2200 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 1000 ppm (2200 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1,3-BUTADIENE-airCarcinogen lowest feasible conc.NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 13410; Number of Industries 20; Total Number of Facilities 2201; Number of Occupations 34; Total Number of Employees Exposed 51971; Total Number of Female Employees Exposed 1410
National Occupational Hazard Survey 1974Hazard Code 13410; Number of Industries 26; Total Number of Facilities 3086; Number of Occupations 71; Total Number of Employees Exposed 66326

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (inhal);clear evidence:mouse
NIOSH Analytical Method, 1994: 1,3-Butadiene, 1024
NIOSH CURRENT INTELLIGENCE BULLETIN 41, 1984
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
NTP Carcinogenesis studies (inhalation);clear evidence:mouse NTPTR* NTP-TR-434,1993
On EPA IRIS database
OSHA ANALYTICAL METHOD #ID-56

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