site ID
NIOSH

Registry of Toxic Effects of Chemical Substances (RTECS)

1-Butanol, 3-methyl-

RTECS #

EL5425000

CAS #

123-51-3

Updated

September 201

Molecular Weight

88.17

Molecular Formula

C5H12O

Synonyms

2-Methyl-4-butanol
3-Methyl butanol
3-Methyl-1-butanol
3-Methylbutan-1-ol
3-Metil-butanolo (Italian)
Alcool amilico (Italian)
Alcool isoamylique (French)
Amylowy alkohol (Polish)
Fermentation amyl alcohol
Isoamyl alcohol
Isoamyl alcohol (ACGIH)
Isoamyl alcohol, primary (OSHA)
Isoamyl alkohol (Czech)
Iso-amylalkohol (German)
Isoamylol
Isobutylcarbinol
Isopentanol
Isopentyl alcohol

Skin and Eye Irritation and References

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Route/OrganismDoseEffectReference
eye /human 150 ppmJIHTAB 25,282,1943
eye /rabbit 20 mg/24H moderate85JCAE -,196,1986
skin /rabbit 20 mg/24H moderate85JCAE -,196,1986

Tumorigenic Data and References

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Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 27 gm/kg/75W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Leukemia		ARGEAR 45,19,1975
subcutaneous/rat lowest published toxic dose: 3800 mg/kg/85W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Leukemia		ARGEAR 45,19,1975

Acute Toxicity Data and References

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Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 150 ppmOlfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Other changes		JIHTAB 25,282,1943
intraperitoneal/mouse lowest published lethal dose: 233 mg/kgFCTXAV 16,785,1978
intraperitoneal/rat lowest published lethal dose: 813 mg/kgAEPPAE 132,214,1928
intravenous/cat lowest published lethal dose: 210 mg/kgFCTXAV 16,785,1978
intravenous/mouse lethal dose (50 percent kill): 234 mg/kgAIPTAK 135,330,1962
intravenous/rabbit lowest published lethal dose: 1570 mg/kgBehavioral: AntipsychoticFCTXAV 16,785,1978
oral/rabbit lethal dose (50 percent kill): 3438 mg/kgEye: Corneal damage

Cardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Dyspnea		IMSUAI 41,31,1972
oral/rat lethal dose (50 percent kill): 1300 mg/kgLiver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Other changes

Blood: Other changes		SAMJAF 43,795,1969
oral/rat lethal dose (50 percent kill): 4300 mg/kgVCVGK* -,108,1984
skin/rabbit lethal dose (50 percent kill): 3970 µL/kgAIHAAP 30,470,1969
subcutaneous/mouse lowest published lethal dose: 7480 mg/kgFCTXAV 16,785,1978

Reviews

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OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 100 ppm;short term exposure limit 125 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWMUREAV 539,77,2003

Standards and Regulations

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OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 100 ppm (360 mg/m3)DTLVS* 3,139,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 100 ppm (361 mg/m3), short term exposure limit 125 ppm (452 mg/m3), JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 100 ppm(366 mg/m3), short term exposure limit 125 ppm(459 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 100 ppm (360 mg/m3), MAY2011
Occupational Exposure Limit-FRANCEVME 100 ppm (360 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 20 ppm (73 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 360 mg/m3, short term exposure limit 1440 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 100 ppm (360 mg/m3), NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 100 ppm (360 mg/m3), MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 100 ppm (360 mg/m3), short term exposure limit 125 ppm (450 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 100 ppm (360 mg/m3);short term exposure limit 125 ppm (450 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 100 ppm (361 mg/m3); short term exposure limit 125 ppm (452 mg/m3), JAN2002
Occupational Exposure Limit-PERUtime-weighted average 100 ppm (360 mg/m3); short term exposure limit 125 ppm (450 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 20 ppm (73 mg/m3), KZG-week 80 ppm (292 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 360 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 100 ppm (360 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 100 ppm (360 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 100 ppm (366 mg/m3);short term exposure limit 125 ppm (458 mg/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 100 ppm (360 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 100 ppm (360 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 100 ppm (360 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 100 ppm (360 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

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OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ISOAMYL ALCOHOL, primary-airtime-weighted average 100 ppm;short term exposure limit 125 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 40380; Number of Industries 43; Total Number of Facilities 3803; Number of Occupations 49; Total Number of Employees Exposed 65499; Total Number of Female Employees Exposed 22006
National Occupational Hazard Survey 1974Hazard Code 40380; Number of Industries 16; Total Number of Facilities 2530; Number of Occupations 18; Total Number of Employees Exposed 24606

Status in Federal Agencies

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OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Alcohols III, 1402

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