Registry of Toxic Effects of Chemical Substances (RTECS)
2-Butanone
RTECS #
EL6475000CAS #
78-93-3Updated
September 201Molecular Weight
72.12Molecular Formula
C4H8OSynonyms
2-Butanone (OSHA)3-Butanone
Acetone, methyl-
Aethylmethylketon (German)
Butanone
Butanone 2 (French)
Ethyl methyl cetone (French)
Ethylmethylketon (Dutch)
Ketone, ethyl methyl
Meetco
MEK (OSHA)
Methyl acetone
Methyl ethyl ketone
Methyl ethyl ketone (ACGIH:OSHA)
Metiletilchetone (Italian)
Metyloetyloketon (Polish)
RCRA waste number U159
Skin and Eye Irritation and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
eye /human | 350 ppm | JIHTAB 25,282,1943 | |
eye /rabbit | 80 mg | TXAPA9 19,276,1971 | |
skin /rabbit | 500 mg/24H | moderate | JIHTAB 25,282,1943 |
skin /rabbit | 402 mg/24H | mild | TXAPA9 19,276,1971 |
skin /rabbit | 14 mg/24H open irritation test | mild | AIHAAP 23,95,1962 |
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
sex chromosome loss and nondisjunction | /Saccharomyes cerevisiae | 33800 ppm | MUREAV 149,339,1985 |
Reproductive Effects Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/rat | 3000 ppm/7H (6-15D pregnant) | Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Specific developmental abnormalities: Homeostasis | TXAPA9 28,452,1974 |
inhalation/rat | 1000 ppm/7H (6-15D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system | TXAPA9 28,452,1974 |
inhalation/mouse | 3000 ppm/7H (6-15D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | FAATDF 16,742,1991 |
inhalation/rat | 2900 mg/m3 (6-10D pregnant) | Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Specific developmental abnormalities: Gastrointestinal system | VCVGK* -,418,1994 |
inhalation/mouse | 3000 ppm (6-15D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Specific developmental abnormalities: Musculoskeletal system | NTIS** #DE89-009563 |
inhalation/rat | 2000 ppm (6-20D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | FCTOD7 44,1287,2006 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
In Vitro/Human, liver tumor | Inhibitor Concentration (50 percent kill): 260 mmol/L/24H | In Vitro Toxicity Studies: Cell protein synthesis | TIVIEQ 3,189,1989 |
inhalation/cat | lowest published toxic concentration: 25000 mg/m3 | Gastrointestinal: Changes in structure or function of salivary glands | VCVGK* -,417,1984 |
inhalation/cat | lowest published toxic concentration: 50000 mg/m3 | Eye: Conjunctiva irritation | VCVGK* -,417,1984 |
inhalation/guinea pig | lowest published toxic concentration: 97300 mg/m3/30M | Behavioral: Ataxia | VCVGK* -,417,1984 |
inhalation/guinea pig | Lowest published lethal concentration: 97300 mg/m3/1H | Lung, Thorax, or Respiration: Emphysema Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGK* -,417,1984 |
inhalation/guinea pig | lowest published toxic concentration: 30000 mg/m3/2M | Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Cough | VCVGK* -,417,1984 |
inhalation/guinea pig | lowest published toxic concentration: 30000 mg/m3/4H | Behavioral: General anesthetic Lung, Thorax, or Respiration: Emphysema Liver: Other changes | VCVGK* -,417,1984 |
inhalation/human | lowest published toxic concentration: 100 ppm/5M | Olfaction: Other olfaction effects Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Other changes | JIHTAB 25,282,1943 |
inhalation/human | lowest published toxic concentration: 1000 mg/m3 | Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Cough | VCVGK* -,417,1994 |
inhalation/human | lowest published toxic concentration: 10 ppm/4H | Cardiac: Pulse rate decreased with fall in BP Lung, Thorax, or Respiration: Other changes | NRTXDN 24,179,2003 |
inhalation/mammal (species unspecified) | lethal concentration (50 percent kill): 38 gm/m3 | GISAAA 51(5),61,1986 | |
inhalation/mouse | lethal concentration (50 percent kill): 32 gm/m3/4H | CUTOEX 1,47,1993 | |
inhalation/mouse | lowest published toxic concentration: 25000 mg/m3/2H | Behavioral: General anesthetic Lung, Thorax, or Respiration: Emphysema Liver: Other changes | VCVGK* -,417,1984 |
inhalation/mouse | Lowest published lethal concentration: 40000 mg/m3 | Lung, Thorax, or Respiration: Emphysema Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGK* -,417,1984 |
inhalation/mouse | lowest published toxic concentration: 4000 ppm/6M | Lung, Thorax, or Respiration: Respiratory depression | TOLED5 9,137,1981 |
inhalation/mouse | lethal concentration (50 percent kill): 32 mg/m3 | ENTOX* -,77,2005 | |
inhalation/rabbit | lowest published toxic concentration: 1250 mg/m3 | Peripheral Nerve and Sensation: Recording from peripheral motor nerve | VCVGK* -,417,1984 |
inhalation/rat | lethal concentration (50 percent kill): 23500 mg/m3/8H | AIHAAP 20,364,1959 | |
inhalation/rat | lethal concentration (50 percent kill): 23500 mg/m3 | ENTOX* -,77,2005 | |
intraperitoneal/guinea pig | lethal dose (50 percent kill): 2 gm/kg | ENTOX* -,77,2005 | |
intraperitoneal/guinea pig | lowest published lethal dose: 2 gm/kg | Liver: Other changes Immunological Including Allergic: Other immediate (humoral): uticaria, allergic rhinitis, serum sickness (multiple organ involvement) Biochemical: Metabolism (intermediary): Lipids including transport | FCTXAV 15,627,1977 |
intraperitoneal/mouse | lethal dose (50 percent kill): 616 mg/kg | ENTOX* -,77,2005 | |
intraperitoneal/rat | lowest published toxic dose: 361 mg/kg | Behavioral: Anticonvulsant | BJPCBM 158,872,2009 |
intraperitoneal/rat | lethal dose (50 percent kill): 607 mg/kg | ENTOX* -,77,2005 | |
oral/human | lowest published lethal dose: 714.3 mg/kg | VCVGK* -,417,1994 | |
oral/mouse | lethal dose (50 percent kill): 3000 mg/kg | VCVGK* -,417,1984 | |
oral/rat | lethal dose (50 percent kill): 2737 mg/kg | ENTOX* -,77,2005 | |
skin/rabbit | lethal dose (50 percent kill): 6480 mg/kg | SHELL* MSDS-5390-4 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/mammal (species unspecified) | lowest published toxic concentration: 588 mg/m3/12H/24W- intermittent | Peripheral Nerve and Sensation: Recording from peripheral motor nerve | VCVGK* -,418,1994 |
inhalation/rat | lowest published toxic concentration: 5000 ppm/6H/90D- intermittent | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Urine volume increased Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | FAATDF 3,264,1983 |
inhalation/rat | lowest published toxic concentration: 750 ppm/7H/7D- intermittent | Liver: Liver function tests impaired | TXAPA9 41,285,1977 |
inhalation/rat | : 4000 ppm/8D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FCTOD7 44,1287,2006 |
inhalation/rat | : 3000 ppm/15D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FCTOD7 44,1287,2006 |
inhalation/rat | : 3000 ppm/15D- intermittent | Liver: Changes in liver weight | FCTOD7 44,1287,2006 |
inhalation/woman | lowest published toxic concentration: 61 mg/m3/169W- intermittent | Peripheral Nerve and Sensation: Sensory change involving peripheral nerve Peripheral Nerve and Sensation: Recording from peripheral motor nerve | VCVGK* -,418,1994 |
subcutaneous/cat | lowest published toxic dose: 55500 mg/kg/37W- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TXAPA9 37,301,1976 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 200 ppm;short term exposure limit 300 ppm | DTLVS* TLV/BEI,2013 |
TOXICOLOGY REVIEW | TOLED5 127,111,2002 | |
TOXICOLOGY REVIEW | NTIS** DE89-563 | |
TOXICOLOGY REVIEW | TOLED5 128,99,2002 | |
TOXICOLOGY REVIEW | TOLED5 140-141,261,2003 | |
TOXICOLOGY REVIEW | ENTOX* -,77,2005 | |
TOXICOLOGY REVIEW | REPTED 25,192,2008 | |
TOXICOLOGY REVIEW | MUREAV 659,93,2008 | |
TOXICOLOGY REVIEW | HUTOX* -,577,1996 | |
TOXICOLOGY REVIEW | HUTOX* -,649,1996 | |
TOXICOLOGY REVIEW | NCLNA* 16,503,1998 | |
TOXICOLOGY REVIEW | NTAPM* -,629,1995 | |
TOXICOLOGY REVIEW | NTAPM* -,727,1995 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | Cancelled | RBREV* -,263,1998 |
Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 200 ppm (590 mg/m3) | DTLVS* 3,29,1971 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
Occupational Exposure Limit-AUSTRALIA | time-weighted average 150 ppm (445 mg/m3), short term exposure limit 300 ppm (890 mg/m3), JUL2008 | |
Occupational Exposure Limit-AUSTRIA | MAK-TMW 100 ppm (295 mg/m3);KZW 200 ppm (590 mg/m3), skin, 2007 | |
Occupational Exposure Limit-BELGIUM | time-weighted average 200 ppm(600 mg/m3), short term exposure limit 300 ppm(900 mg/m3), MAR2002 | |
Occupational Exposure Limit-DENMARK | time-weighted average 50 ppm (145 mg/m3), skin, MAY2011 | |
Occupational Exposure Limit-EC | time-weighted average 600 mg/m3 (200 ppm);short term exposure limit 900 mg/m3 (300 ppm), JUN2000 | |
Occupational Exposure Limit-FINLAND | short term exposure limit 100 ppm (300 mg/m3), skin, NOV2011 | |
Occupational Exposure Limit-FRANCE | VME 200 ppm (600 mg/m3), VLE 300 ppm (900 mg/m3), FEB2006 | |
Occupational Exposure Limit-GERMANY | MAK 200 ppm (600 mg/m3), 2011 | |
Occupational Exposure Limit-HUNGARY | time-weighted average 600 mg/m3, short term exposure limit 900 mg/m3, Skin, SEP2000 | |
Occupational Exposure Limit-ICELAND | time-weighted average 50 ppm (145 mg/m3), short term exposure limit 300 ppm (900 mg/m3), skin, NOV2011 | |
Occupational Exposure Limit-INDIA | time-weighted average 200 ppm (590 mg/m3), short term exposure limit 300 ppm (885 mg/m3), JAN1993 | |
Occupational Exposure Limit-JAPAN | Occupational Exposure Limit 200 ppm (590 mg/m3), MAY2012 | |
Occupational Exposure Limit-KOREA | time-weighted average 200 ppm (590 mg/m3), short term exposure limit 300 ppm (885 mg/m3), 2006 | |
Occupational Exposure Limit-MEXICO | time-weighted average 200 ppm (590 mg/m3);short term exposure limit 300 ppm (885 mg/m3), 2004 | |
Occupational Exposure Limit-NEW ZEALAND | time-weighted average 150 ppm (445 mg/m3); short term exposure limit 300 ppm (890 mg/m3), JAN2002 | |
Occupational Exposure Limit-NORWAY | time-weighted average 75 ppm (220 mg/m3), JAN1999 | |
Occupational Exposure Limit-PERU | time-weighted average 200 ppm (590 mg/m3); short term exposure limit 300 ppm (885 mg/m3), JUL2005 | |
Occupational Exposure Limit-POLAND | MAC(time-weighted average) 200 mg/m3, MAC(short term exposure limit) 850 mg/m3, JAN1999 | |
Occupational Exposure Limit-RUSSIA | time-weighted average 200 mg/m3, short term exposure limit 400 mg/m3, JUN2003 | |
Occupational Exposure Limit-SWEDEN | time-weighted average 50 ppm (150 mg/m3);short term exposure limit 100 ppm (300 mg/m3), JUN2005 | |
Occupational Exposure Limit-SWITZERLAND | ceiling concentration 200 ppm (590 mg/m3), skin, JAN2011 | |
Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 590 mg/m3, Skin, 2003 | |
Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 200 ppm (590 mg/m3), JAN1993 | |
Occupational Exposure Limit-TURKEY | time-weighted average 200 ppm (590 mg/m3), JAN1993 | |
Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 200 ppm (600 mg/m3);short term exposure limit 300 ppm (899 mg/m3), skin, OCT2007 | |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 200 ppm (590 mg/m3) | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 200 ppm (590 mg/m3) | CFRGBR 41,50-204.50,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 200 ppm (590 mg/m3) | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 200 ppm (590 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL ETHYL KETONE-air | 10H time-weighted average 200 ppm;short term exposure limit 300 ppm | NIOSH* DHHS #92-100,1992 |
National Occupational Exposure Survey 1983 | Hazard Code 13980; Number of Industries 318; Total Number of Facilities 87227; Number of Occupations 208; Total Number of Employees Exposed 1447456; Total Number of Female Employees Exposed 245372 | |
National Occupational Hazard Survey 1974 | Hazard Code 13980; Number of Industries 319; Total Number of Facilities 64013; Number of Occupations 177; Total Number of Employees Exposed 801382 |
Status in Federal Agencies
Organization | Reference |
---|---|
ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/110708/AS) | |
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay | |
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE | FEREAC 47,26992,82 |
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
EPA TSCA Section 8(d) unpublished health/safety studies | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
NIOSH Analytical Method, 1994: Methyl ethyl ketone, 2500; in blood, 8002 | |
NIOSH Analytical Method, 1996: Volatile organic compound, 2549 | |
On EPA IRIS database | |
OSHA ANALYTICAL METHOD #1004 | |
OSHA ANALYTICAL METHOD #84 |
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division