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Registry of Toxic Effects of Chemical Substances (RTECS)

2-Butanone, peroxide

RTECS #

EL9450000

CAS #

1338-23-4

Updated

September 201

Molecular Weight

176.24

Molecular Formula

C8H16O4

Synonyms

Butanox LPT
Butanox M 105
Butanox M 50
Chaloxyd MEKP-HA 1
Chaloxyd MEKP-LA 1
Esperfoam FR
Ethyl methyl ketone peroxide
FR 222
HI-Point 180
HI-Point 90
HI-Point PD-1
Kayamek A
Kayamek M
Ketonox
Lucidol DDM 9
Lucidol Delta X
Lupersol DDA 30
Lupersol DDM
Lupersol Delta X
Lupersol DNF
Lupersol DSW
MEK peroxide
MEKPO
Mepox
Methyl ethyl ketone hydroperoxide
Methyl ethyl ketone peroxide
Methyl ethyl ketone peroxide (ACGIH)
Methylethylketonhydroperoxide
NCI-C55447
Permek G
Permek N
Quickset Extra
Quickset super
RCRA waste number U160
Sprayset MEKP
Superox 46-710
Thermacure

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 3 mgAIHAAP 19,205,1958
eye /rabbit 40%VCVGK* -,529,1994
skin /rabbit 500 mgAIHAAP 19,205,1958

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium104 µg/plate/72H (-enzymatic activation step)MUTAEX 15,495,2000

Tumorigenic Data and References

Route/OrganismDoseEffectReference
unreported route/mouse lowest published toxic dose: 282 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Lymphoma including Hodgkin's disease		RARSAM 3,193,1963

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 170 ppm/4HLung, Thorax, or Respiration: DyspneaAIHAAP 19,205,1958
inhalation/mouse lethal concentration (50 percent kill): 2500 mg/m3/4HEye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough		VCVGK* -,528,1994
inhalation/rat lethal concentration (50 percent kill): 3600 mg/m3/4HEye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough		VCVGK* -,528,1994
inhalation/rat lethal concentration (50 percent kill): 200 ppm/4HLung, Thorax, or Respiration: DyspneaAIHAAP 19,205,1958
intraperitoneal/mouse lethal dose (50 percent kill): 200 mg/kgVCVGK* -,528,1994
intraperitoneal/rat lowest published toxic dose: 90 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)		VCVGK* -,528,1994
intraperitoneal/rat lethal dose (50 percent kill): 65 mg/kgBehavioral: Muscle weakness

Behavioral: Ataxia		AIHAAP 19,205,1958
oral/human lowest published toxic dose: 480 mg/kgGastrointestinal: Changes in structure or function of esophagus

Gastrointestinal: Nausea or vomiting

Gastrointestinal: Other changes		NCPBBY Jan/Feb,1969
oral/man lowest published toxic dose: 0.57 gm/kgGastrointestinal: Ulceration or bleeding from stomach

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases		JTCTDW 46,74,2008
oral/mouse lethal dose (50 percent kill): 250 mg/kgVCVGK* -,528,1994
oral/rat lethal dose (50 percent kill): 470 mg/kgVCVGK* -,528,1994
skin/rabbit lowest published toxic dose: 2000 mg/kgSkin: After topical application: Primary irritationVCVGK* -,528,1994

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published toxic dose: 273 mg/kg/7W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldAIHAAP 19,205,1958
oral/rat lowest published toxic dose: 2033 mg/kg/7W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		AIHAAP 19,205,1958
skin/mouse lowest published toxic dose: 141 mg/kg/4W- intermittentBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationCRNGDP 25,431,2004

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-ceiling concentration 0.2 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWHUTOX* -,649,1996

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAceiling concentration 0.2 ppm (1.5 mg/m3), JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.2 ppm (1.5 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKceiling concentration 1 mg/m3, MAY2011
Occupational Exposure Limit-FINLANDshort term exposure limit 0.2 ppm (1.5 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVLE 0.2 ppm (1.5 mg/m3), FEB2006
Occupational Exposure Limit-ICELANDshort term exposure limit 0.1 ppm (1 mg/m3), NOV2011
Occupational Exposure Limit-KOREAceiling concentration 0.2 ppm (1.5 mg/m3), 2006
Occupational Exposure Limit-NEW ZEALANDceiling concentration 0.2 ppm (1.5 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 1 mg/m3, JAN1999
Occupational Exposure Limit-PERUshort term exposure limit 0,2 ppm (1,4 mg/m3), JUL2005
Occupational Exposure Limit-SWEDENceiling concentration 0.2 ppm (1.5 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.2 ppm (1.5 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-C 1.5 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMshort term exposure limit 0.2 ppm (1.5 mg/m3), OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL ETHYL KETONE PEROXIDE-airceiling concentration 0.2 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 80105; Number of Industries 23; Total Number of Facilities 1879; Number of Occupations 31; Total Number of Employees Exposed 25827; Total Number of Female Employees Exposed 6514
National Occupational Hazard Survey 1974Hazard Code 80105; Number of Industries 29; Total Number of Facilities 2226; Number of Occupations 31; Total Number of Employees Exposed 20053

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Methyl ethyl ketone peroxide, 3508
NTP Toxicity studies, RPT# TOX-18, October 2000
On EPA IRIS database
OSHA ANALYTICAL METHOD #77

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