Registry of Toxic Effects of Chemical Substances (RTECS)
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Butyl alcohol
RTECS #
EO1400000CAS #
71-36-3; 42031-19-6; 107569-51-7; 220713-25-7Updated
September 201Molecular Weight
74.14Molecular Formula
C4H10OSynonyms
1-Butanol1-Butyl alcohol
1-Hydroxybutane
Alcool butylique (French)
Butan-1-ol
Butanol
Butanolen (Dutch)
Butanolo (Italian)
Butyl hydroxide
Butylowy alkohol (Polish)
Butyric or normal primary butyl alcohol
CCS 203
Hemostyp
Methylolpropane
n-Butan-1-ol
n-Butanol
n-Butanol (ACGIH)
n-Butyl alcohol
n-Butyl alcohol (OSHA)
Propylcarbinol
Propylmethanol
RCRA waste number U031
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /human | 50 ppm | JIHTAB 25,282,1943 | |
| eye /human | 990 ppm/1H | HPV112 -,-,2008 | |
| eye /rabbit | 1.62 mg | severe | HPV112 -,-,2008 |
| eye /rabbit | 0.005 mL | severe | HPV112 -,-,2008 |
| eye /rabbit | 2 mg/24H | severe | 85JCAE -,193,1986 |
| skin /human | 20 µL/20M | HPV112 -,-,2008 | |
| skin /rabbit | 20 mg/24H | moderate | 85JCAE -,193,1986 |
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| sex chromosome loss and nondisjunction | /Aspergillus nidulans | 7000 ppm | MUREAV 215,187,1989 |
| sex chromosome loss and nondisjunction | lung/hamster | 100 mmol/L | MUREAV 182,135,1987 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | 6000 ppm/7H (1-19D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | FAATDF 12,469,1989 |
| inhalation/rat | 8000 ppm/7H (1-19D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system | FAATDF 12,469,1989 |
| inhalation/rat | 6000 ppm (1-20D pregnant) | Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Behavioral | HPV112 -,-,2008 |
| oral/rat | 113 gm/kg (1-20D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system | TOXID9 44,58,2005 |
| oral/rat | 35295 mg/kg (1-15D pregnant) | Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | ONGZAC 22(1),71,1991 |
| oral/rat | 35295 mg/kg (1-15D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Effects on newborn: Biochemical and metabolic | ONGZAC 22(1),71,1991 |
| oral/rat | 23100 mg/kg (8W prior to copulation/0-20D pregnant) | Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Specific developmental abnormalities: Musculoskeletal system | IOMHEZ 7,365,1994 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye/human | lowest published toxic dose: 72.5 mg/m3 | Eye: Conjunctiva irritation | VCVGK* -,103,1984 |
| In Vitro/Hamster, lung fibroblast | Inhibitor Concentration Low: >76.3 mmol/L/24H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | TIVIEQ 1,3,1987 |
| In Vitro/Human, liver tumor | Inhibitor Concentration Low: >76.3 mmol/L/24H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | TIVIEQ 1,3,1987 |
| In Vitro/Human, liver tumor | Inhibitor Concentration (50 percent kill): 57 mmol/L/24H | In Vitro Toxicity Studies: Cell protein synthesis | TIVIEQ 3,189,1989 |
| In Vitro/Mouse, fibroblast | Inhibitor Concentration Low: >65.4 mmol/L/24H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | TIVIEQ 1,3,1987 |
| In Vitro/Mouse, macrophage | Inhibitor Concentration Low: >76.3 mmol/L/24H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | TIVIEQ 1,3,1987 |
| inhalation/human | lowest published toxic concentration: 25 ppm | Olfaction: Other olfaction effects Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Other changes | JIHTAB 25,282,1943 |
| inhalation/mammal (species unspecified) | lethal concentration (50 percent kill): 28400 mg/m3 | GISAAA 51(5),61,1986 | |
| inhalation/mouse | lowest published toxic concentration: 500 ppm/6M | Lung, Thorax, or Respiration: Respiratory depression | TOLED5 9,137,1981 |
| inhalation/mouse | lowest published toxic concentration: 6600 ppm/2H | Behavioral: Somnolence (general depressed activity) | HPV112 -,-,2008 |
| inhalation/mouse | lowest published toxic concentration: 3010 ppm/4H | Lung, Thorax, or Respiration: Respiratory depression | HPV112 -,-,2008 |
| inhalation/rat | lowest published toxic concentration: 6530 ppm/4H | Behavioral: Muscle weakness | HPV112 -,-,2008 |
| inhalation/rat | lowest published toxic concentration: 7200 ppm/8H | Behavioral: Somnolence (general depressed activity) | HPV112 -,-,2008 |
| inhalation/rat | lethal concentration (50 percent kill): >8000 ppm/4H | HPV112 -,-,2008 | |
| inhalation/rat | lowest published toxic concentration: 1500 mg/m3 | Lung, Thorax, or Respiration: Other changes | VCVGK* -,101,1984 |
| inhalation/rat | lowest published toxic concentration: 4600 mg/m3/4H | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases | VCVGK* -,101,1984 |
| inhalation/rat | lowest published toxic concentration: 7400 mg/m3/4H | Liver: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases | VCVGK* -,101,1984 |
| inhalation/rat | lethal concentration (50 percent kill): 24000 mg/m3/4H | VCVGK* -,101,1984 | |
| intraperitoneal/mouse | lethal dose (50 percent kill): 254 mg/kg | Liver: Other changes | RCOCB8 26,75,1979 |
| intraperitoneal/rat | lethal dose (50 percent kill): 200 mg/kg | VCVGK* -,101,1984 | |
| intraperitoneal/rat | lowest published toxic dose: 400 mg/kg | Behavioral: Ataxia | VCVGK* -,101,1984 |
| intravenous/cat | lowest published lethal dose: 243 mg/kg | JPETAB 16,1,1920 | |
| intravenous/mouse | lethal dose (50 percent kill): 377 mg/kg | AIPTAK 135,330,1962 | |
| intravenous/rat | lethal dose (50 percent kill): 310 mg/kg | EVHPAZ 61,321,1985 | |
| oral/Dog | lowest published lethal dose: 1760 mg/kg | Gastrointestinal: Other changes Blood: Hemorrhage | COREAF 81,192,1875 |
| oral/Dog | lethal dose (50 percent kill): 1782 mg/kg | HPV112 -,-,2008 | |
| oral/hamster | lethal dose (50 percent kill): 1.2 gm/kg | HPV112 -,-,2008 | |
| oral/human | lowest published lethal dose: 428 mg/kg | VCVGK* -,103,1984 | |
| oral/mouse | lethal dose (50 percent kill): 100 mg/kg | VCVGK* -,101,1984 | |
| oral/rabbit | lethal dose (50 percent kill): 3484 mg/kg | Eye: Corneal damage Cardiac: Pulse rate decreased with fall in BP Lung, Thorax, or Respiration: Dyspnea | IMSUAI 41,31,1972 |
| oral/rabbit | lowest published toxic dose: 0.8 gm/kg | Behavioral: General anesthetic | HPV112 -,-,2008 |
| oral/rabbit | lethal dose (50 percent kill): 3400 mg/kg | VCVGK* -,102,1984 | |
| oral/rat | lethal dose (50 percent kill): 4.36 gm/kg | Gastrointestinal: Gastritis Liver: Other changes Blood: Hemorrhage | HPV112 -,-,2008 |
| oral/rat | lethal dose (50 percent kill): 0.79 gm/kg | HPV112 -,-,2008 | |
| oral/rat | lethal dose (50 percent kill): 790 mg/kg | Liver: Fatty liver degeneration Kidney, Ureter, and Bladder: Other changes Blood: Other changes | SAMJAF 43,795,1969 |
| oral/wild bird | lethal dose (50 percent kill): 2500 mg/kg | AECTCV 12,355,1983 | |
| skin/rabbit | lethal dose (50 percent kill): 3400 mg/kg | NPIRI* 1,10,1974 | |
| skin/rabbit | lowest published lethal dose: 5 mL/kg | HPV112 -,-,2008 | |
| subcutaneous/Dog | lowest published lethal dose: 2 gm/kg | Gastrointestinal: Other changes Blood: Hemorrhage | COREAF 81,192,1875 |
| subcutaneous/mouse | lethal dose (50 percent kill): 3200 mg/kg | TXAPA9 18,185,1971 | |
| unreported route/rabbit | lowest published lethal dose: 3500 mg/kg | THMOAM 6,327,1892 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/mammal (species unspecified) | lowest published toxic concentration: 5 mg/m3/4H/5W- intermittent | Liver: Changes in liver weight | VCVGK* -,103,1994 |
| inhalation/mouse | lowest published toxic concentration: 6600 µg/m3/24H/17W- continuous | Brain and Coverings: Recordings from specific areas of CNS Liver: Liver function tests impaired Nutritional and Gross Metabolic: Other changes | GISAAA 41(11),12,1976 |
| inhalation/rat | lowest published toxic concentration: 1.36 mg/m3/30D- continuous | Brain and Coverings: Other degenerative changes | TOLED5 135,S122,2002 |
| inhalation/rat | lowest published toxic concentration: 14.6 mg/m3/30D- continuous | Liver: Multiple effects Endocrine: Changes in adrenal weight | TOLED5 135,S122,2002 |
| inhalation/rat | lowest published toxic concentration: 212 mg/m3/5H/26W- intermittent | Immunological Including Allergic: Increase in cellular immune response | VCVGK* -,103,1994 |
| inhalation/rat | lowest published toxic concentration: 6.6 mg/m3/5H/122D- intermittent | Brain and Coverings: Other degenerative changes | VCVGK* -,103,1994 |
| inhalation/rat | lowest published toxic concentration: 20 mg/m3/24H/90D- continuous | Brain and Coverings: Other degenerative changes Behavioral: Somnolence (general depressed activity) Gastrointestinal: Other changes | VCVGK* -,103,1994 |
| inhalation/rat | lowest published toxic concentration: 6600 µg/m3/24H/17W- continuous | Brain and Coverings: Recordings from specific areas of CNS Vascular: Regional or general arteriolar or venous dilation Liver: Liver function tests impaired | GISAAA 41(11),12,1976 |
| inhalation/rat | lowest published toxic concentration: 2000 ppm/6H/3D- intermittent | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes | ATSUDG 8,418,1985 |
| oral/rat | lowest published toxic dose: 46500 mg/kg/13W- intermittent | Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia Blood: Changes in erythrocyte (RBC) count | NTIS** OTS0531032 |
| oral/rat | lowest published toxic dose: 7 mL/kg/7D- intermittent | Liver: Other changes Biochemical: Effect on specific coenzyme: B vitamins including folate | JDGRAX 10(1-2),25,1978 |
| oral/rat | lowest published toxic dose: 1 mg/kg/5D- intermittent | Endocrine: Changes in adrenal weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases | TOLED5 135,S122,2002 |
| oral/rat | lowest published toxic dose: 4 mg/kg/20D- intermittent | Endocrine: Changes in adrenal weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases | TOLED5 135,S122,2002 |
| oral/rat | lowest published toxic dose: 6 mg/kg/30D- intermittent | Endocrine: Changes in adrenal weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases | TOLED5 135,S122,2002 |
| oral/rat | lowest published toxic dose: 113080 mg/kg/20D- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TOXID9 44,58,2005 |
| oral/rat | lowest published toxic dose: 45500 mg/kg/13W- intermittent | Behavioral: Ataxia | HPV112 -,-,2008 |
| skin/rabbit | lowest published toxic dose: 136080 mg/kg/4D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | HPV112 -,-,2008 |
| subcutaneous/rat | lowest published toxic dose: 157 mg/kg/4D- intermittent | Behavioral: Ataxia | NETEEC 10,81,1988 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 20 ppm | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | JACTDZ 6(3),403,1987 | |
| TOXICOLOGY REVIEW | TOLED5 140-141,239,2003 | |
| TOXICOLOGY REVIEW | MUREAV 628,67,2007 | |
| TOXICOLOGY REVIEW | NCLNA* 16,503,1998 | |
| TOXICOLOGY REVIEW | NTAPM* -,629,1995 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 100 ppm (300 mg/m3) | DTLVS* 3,31,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | ceiling concentration 50 ppm (152 mg/m3), JUL2008 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 50 ppm (154 mg/m3), Skin, MAR2002 | |
| Occupational Exposure Limit-DENMARK | ceiling concentration 50 ppm (150 mg/m3), skin, MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 50 ppm (150 mg/m3), short term exposure limit 75 ppm (230 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VLE 50 ppm (150 mg/m3), FEB2006 | |
| Occupational Exposure Limit-GERMANY | MAK 100 ppm (310 mg/m3), 2011 | |
| Occupational Exposure Limit-HUNGARY | time-weighted average 45 mg/m3, short term exposure limit 90 mg/m3, Skin, SEP2000 | |
| Occupational Exposure Limit-ICELAND | short term exposure limit 50 ppm (150 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-INDIA | time-weighted average 50 ppm (150 mg/m3), Skin, JAN1993 | |
| Occupational Exposure Limit-JAPAN | ceiling concentration 50 ppm (150 mg/m3), skin, MAY2012 | |
| Occupational Exposure Limit-KOREA | ceiling concentration 50 ppm (150 mg/m3), 2006 | |
| Occupational Exposure Limit-MEXICO | peak 50 ppm (150 mg/m3) (skin), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | ceiling concentration 50 ppm (150 mg/m3), skin, JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 25 ppm (75 mg/m3), JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 20 ppm (61 mg/m3); short term exposure limit 50 ppm (152 mg/m3), JUL2005 | |
| Occupational Exposure Limit-POLAND | time-weighted average 50 mg/m3, short term exposure limit 140 mg/m3, JAN1999 | |
| Occupational Exposure Limit-RUSSIA | time-weighted average 10 mg/m3, short term exposure limit 30 mg/m3, JUN2003 | |
| Occupational Exposure Limit-SWEDEN | time-weighted average 15 ppm (45 mg/m3), ceiling concentration 30 ppm (90 mg/m3), Skin, JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | ceiling concentration 50 ppm (150 mg/m3), JAN2011 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 100 ppm (300 mg/m3), JAN1993 | |
| Occupational Exposure Limit-TURKEY | time-weighted average 100 ppm (300 mg/m3), JAN1993 | |
| Occupational Exposure Limit-UNITED KINGDOM | short term exposure limit 50 ppm (154 mg/m3), skin, OCT2007 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 100 ppm (300 mg/m3) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 100 ppm (300 mg/m3) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 100 ppm (300 mg/m3) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 100 ppm (300 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO n-BUTYL ALCOHOL-air | ceiling concentration 50 ppm (Sk) | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 13850; Number of Industries 304; Total Number of Facilities 57416; Number of Occupations 179; Total Number of Employees Exposed 1059965; Total Number of Female Employees Exposed 269422 | |
| National Occupational Hazard Survey 1974 | Hazard Code 13850; Number of Industries 306; Total Number of Facilities 60975; Number of Occupations 160; Total Number of Employees Exposed 678026 |
Status in Federal Agencies
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division