Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Butylamine

RTECS #

EO2975000

CAS #

109-73-9

Updated

September 201

Molecular Weight

73.16

Molecular Formula

C4H11N

Synonyms

1-Amino-butaan (Dutch)
1-Aminobutan (German)
1-Aminobutane
1-Butanamine
Butylamine (OSHA)
Monobutilamina (Romanian)
Monobutylamine
Mono-n-butylamine
n-Butilamina (Italian)
n-Butylamin (German)
n-Butylamine
n-Butylamine (ACGIH)
Norvalamine

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 250 µg/24H severe85JCAE -,431,1986
skin /rabbit 10 mg/24H open irritation testJIHTAB 26,269,1944
skin /rabbit 500 mg open irritation test severeUCDS** 7/19/1965

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisoral/rat110 mg/kgZKKOBW 86,47,1976

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 2.4 gm/kg (1-6D pregnant)Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Other developmental abnormalities		FCTOD7 40,1833,2002
oral/rat 6 gm/kg (1-6D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system		FCTOD7 40,1833,2002

Tumorigenic Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 800 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors		BCPCA6 2,168,1959

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/cat lowest published toxic concentration: 0.5 gm/m3Behavioral: Alteration of classical conditioningTPKVAL 7,56,1965
inhalation/human lowest published toxic concentration: 0.1 gm/m3Gastrointestinal: Other changes

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)		TPKVAL 7,56,1965
inhalation/mammal (species unspecified) Lowest published lethal concentration: 8 gm/m3Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Lung, Thorax, or Respiration: Respiratory obstruction		TPKVAL 7,56,1965
inhalation/mouse lethal concentration (50 percent kill): 800 mg/m3/4HENTOX* -,360,2005
inhalation/mouse lethal concentration (50 percent kill): 800 mg/m3/2H85GMAT -,28,1982
inhalation/rat Lowest published lethal concentration: 4000 ppm/4HJIHTAB 31,343,1949
intraperitoneal/mouse lethal dose (50 percent kill): 629 mg/kgJPETAB 88,82,1946
intravenous/mouse lethal dose (50 percent kill): 198 mg/kgJPETAB 88,82,1946
oral/guinea pig lethal dose (50 percent kill): 430 mg/kgGISAAA 40(11),21,1975
oral/mouse lethal dose (50 percent kill): 430 mg/kgGISAAA 40(11),21,1975
oral/rat lethal dose (50 percent kill): 366 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression		TXAPA9 63,150,1982
oral/rat lethal dose (50 percent kill): 366 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Acute pulmonary edema		ENTOX* -,360,2005
parenteral/rat lowest published lethal dose: 600 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Coma

Lung, Thorax, or Respiration: Dyspnea		JPETAB 20,435,1923
skin/guinea pig lethal dose (50 percent kill): 500 µL/kgJIHTAB 26,269,1944
skin/rabbit lethal dose (50 percent kill): 850 mg/kgENTOX* -,360,2005
skin/rabbit lethal dose (50 percent kill): 850 µL/kgUCDS** 7/19/1965
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 590 mg/kgTPKVAL 14,80,1975

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 17 ppm/6H/14D- intermittentOlfaction: Other olfaction effectsFCTOD7 40,1833,2002
intramuscular/rat lowest published toxic dose: 6 gm/kg/6D- intermittentBehavioral: Food intake (animal)FCTOD7 40,1833,2002

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-ceiling concentration 5 ppm (skin)DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWCHREAY 9,389,1931
TOXICOLOGY REVIEWENTOX* -,360,2005

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARDair-ceiling concentration 5 ppm (15 mg/m3) (skin)DTLVS* 3,32,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAceiling concentration 5 ppm (15 mg/m3), JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 5 ppm (15 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKceiling concentration 5 ppm (15 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDshort term exposure limit 5 ppm (15 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVLE 5 ppm (15 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 2 ppm (6.1 mg/m3), 2011
Occupational Exposure Limit-ICELANDshort term exposure limit 5 ppm (15 mg/m3), skin, NOV2011
Occupational Exposure Limit-JAPANceiling concentration 5 ppm (15 mg/m3), skin, MAY2012
Occupational Exposure Limit-KOREAceiling concentration 5 ppm (15 mg/m3), skin, 2006
Occupational Exposure Limit-MEXICOpeak 5 ppm (15 mg/m3) (skin), 2004
Occupational Exposure Limit-NORWAYtime-weighted average 5 ppm (15 mg/m3), JAN1999
Occupational Exposure Limit-PERUshort term exposure limit 5 ppm (15 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENceiling concentration 5 ppm (15 mg/m3), Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 2 ppm (6.1 mg/m3), KZG-week 4 ppm (12.2 mg/m3), skin, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 5 ppm (15 mg/m3), JAN1993
Occupational Exposure Limit-THE NETHERLANDSMAC-C 15 mg/m3, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 5 ppm (15 mg/m3), Skin, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 5 ppm (15 mg/m3), Skin, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)ceiling concentration 5 ppm (15 mg/m3) (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)ceiling concentration 5 ppm (15 mg/m3) (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)ceiling concentration 5 ppm (15 mg/m3) (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)ceiling concentration 5 ppm (15 mg/m3) (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BUTYLAMINE-airceiling concentration 5 ppm (Sk)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 14440; Number of Industries 2; Total Number of Facilities 20; Number of Occupations 1; Total Number of Employees Exposed 414; Total Number of Female Employees Exposed 85
National Occupational Hazard Survey 1974Hazard Code 14440; Number of Industries 4; Total Number of Facilities 97; Number of Occupations 9; Total Number of Employees Exposed 1168

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: n-Butylamine, 2012

Follow NIOSH

NIOSH Homepage

TOP