Registry of Toxic Effects of Chemical Substances (RTECS)
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Carbamic acid, methyl-, 2,3-dihydro-2,2-dimethyl-7-benzofuranyl ester
RTECS #
FB9450000CAS #
1563-66-2Updated
September 201Molecular Weight
221.28Molecular Formula
C12H15NO3Synonyms
2,2-Dimethyl-2,3-dihydro-7-benzofuranyl N-methylcarbamate2,2-Dimethyl-7-coumaranyl N-methylcarbamate
2,3-Dihydro-2,2-dimethyl-7-benzofuranyl methylcarbamate
2,3-Dihydro-2,2-dimethylbenzofuran-7-yl methylcarbamate
2,3-Dihydro-2,2-dimethylbenzofuranyl-7-N-methylcarbamate
7-Benzofuranol, 2,3-dihydro-2,2-dimethyl-, methylcarbamate (9CI)
BAY 70143
C2292-59A
Carbamic acid, methyl-, 2,2-dimethyl-2,3-dihydrobenzofuran-7-yl ester
Carbofuran
Carbofuran (ACGIH)
Carbofurane
Chinufur
Crisfuran
Curaterr
D 1221
ENT 27,164
FMC 10242
Furacarb
Furadan
Furadan 3G
Furadan 4F
Furadan 75 WP
Furadane
Furodan
Karbofuranu (Polish)
ME F248
Methyl carbamic acid 2,3-dihydro-2,2-dimethyl-7-benzofuranyl ester
NIA 10242
NIA 10242 75 WP
Niagara 10242
Niagara nia-10242
N-Metylokarbaminian 2,3-dwuwodoro-2,2-dwumetylobenzofuranylu-7 (Polish)
OMS-864
Yaltox
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| skin /rabbit | 500 mg | mild | HPV028 -,-,2004 |
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| Cytogenetic Analysis | lymphocyte/human | 100 mg/L | TGANAK 18(1),17,1984 |
| Cytogenetic Analysis | oral/mouse | 3800 µg/kg | MUREAV 465,123,2000 |
| Cytogenetic Analysis | ovary/hamster | 0.15 mg/L/2H | FCTOD7 45,928,2007 |
| micronucleus test | ovary/hamster | 10 mg/L/24H | MUREAV 656,68,2008 |
| mutation in mammalian somatic cells | lung/hamster | 500 µmol/L | ENVRAL 29,48,1982 |
| mutation in microorganisms | /Salmonella typhimurium | 10 mg/plate (+/-enzymatic activation step) | MUREAV 116,185,1983 |
| mutation in microorganisms | /Other microorganisms | 60 mg/L (-enzymatic activation step) | MILEDM 12,79,1979 |
| mutation in microorganisms | /Salmonella typhimurium | 1048 µg/plate (-enzymatic activation step) | HPV028 -,-,2004 |
| other mutation test systems | oral/mouse | 5700 µg/kg | MUREAV 465,123,2000 |
| sister chromatid exchange | lymphocyte/human | 5 mg/L | MUREAV 147,296,1985 |
| sister chromatid exchange | ovary/hamster | 10 mg/L/24H | MUREAV 656,68,2008 |
| sperm morphology | intraperitoneal/mouse | 2 mg/kg | MUREAV 465,123,2000 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/rat | 70 mg/kg (6-19D pregnant) | Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | JPFCD2 20,373,1985 |
| oral/rat | 86 mg/kg (60D male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct | HETOEA 14,889,1995 |
| oral/mouse | 210 µg/kg (1-21D pregnant) | Reproductive: Effects on newborn: Biochemical and metabolic | JEPTDQ 2(2),357,1978 |
| oral/mouse | 10500 µg/kg (1-21D pregnant) | Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Delayed effects | JEPTDQ 4(5-6),53,1980 |
| oral/mouse | 220 mg/kg (6-16D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system | JPFCD2 20,373,1985 |
| oral/mouse | 110 mg/kg (6-16D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Effects on embryo or fetus: Fetal death | JPFCD2 20,373,1985 |
| oral/man | 6200 µg/kg (multigeneration) | Reproductive: Effects on newborn: Delayed effects | JRPFA4 113,95,1998 |
| oral/rat | 12 mg/kg (60D male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct | TOXID9 -,193,2008 |
| oral/rat | 124.8 mg/kg (multigeneration) | Reproductive: Other effects on male Reproductive: Other effects on female Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | HPV028 -,-,2004 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| In Vitro/Rat, neurons | Inhibitor Concentration (50 percent kill): 35.5 µmol/L/2H | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TIVIEQ 3,111,1989 |
| inhalation/Dog | lethal concentration (50 percent kill): 52 mg/m3 | Eye: Other eye effects Gastrointestinal: Changes in structure or function of salivary glands Gastrointestinal: Nausea or vomiting | JJOMDZ 12,16,1970 |
| inhalation/rat | lethal concentration (50 percent kill): 85 mg/m3 | Eye: Other eye effects Gastrointestinal: Changes in structure or function of salivary glands Gastrointestinal: Nausea or vomiting | JJOMDZ 12,16,1970 |
| inhalation/rat | lowest published toxic concentration: 50 mg/m3 | Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Other changes | HPV028 -,-,2004 |
| intraperitoneal/rat | lowest published toxic dose: 1.5 mg/kg | Cardiac: Cardiomyopathy including infarction Musculoskeletal: Other changes Biochemical: Metabolism (intermediary): Other proteins | TXCYAC 266,48,2009 |
| intraperitoneal/rat | lowest published toxic dose: 1.5 mg/kg | Cardiac: Other changes | TXCYAC 271,36,2010 |
| intravenous/mouse | lethal dose (50 percent kill): 450 µg/kg | CSLNX* NX#11280 | |
| oral/chicken | lethal dose (50 percent kill): 6300 µg/kg | Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia | TXAPA9 11,49,1967 |
| oral/Dog | lethal dose (50 percent kill): 19 mg/kg | Eye: Other eye effects Gastrointestinal: Changes in structure or function of salivary glands Gastrointestinal: Nausea or vomiting | JJOMDZ 12,16,1970 |
| oral/Dog | lethal dose (50 percent kill): 19 mg/kg | HBPTO* 2,1094,2001 | |
| oral/domestic bird | lowest published toxic dose: 0.5 mg/kg | Liver: Hepatitis (hepatocellular necrosis), diffuse Blood: Hemorrhage Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | TOXID9 90,322,2006 |
| oral/duck | lethal dose (50 percent kill): 415 µg/kg | TXAPA9 22,556,1972 | |
| oral/man | lowest published toxic dose: 3571 mg/kg | Peripheral Nerve and Sensation: Fasciculations Cardiac: Change in rate Lung, Thorax, or Respiration: Dyspnea | JTCTDW 43,867,2005 |
| oral/man | lowest published toxic dose: 1428.6 µL/kg | Peripheral Nerve and Sensation: Paresthesia Eye: Miosis (pupilliary constriction) Nutritional and Gross Metabolic: Body temperature increase | JTCTDW 38,43,2000 |
| oral/man | lowest published toxic dose: 1.43 mL/kg | Peripheral Nerve and Sensation: Paresthesia Autonomic Nervous System: Other (direct) parasympathomimetic Behavioral: Muscle weakness | JTCTDW 38,43,2000 |
| oral/mouse | lethal dose (50 percent kill): 2 mg/kg | HBPTO* 2,1094,2001 | |
| oral/pigeon | lowest published toxic dose: 0.5 mg/kg | Behavioral: Change in psychophysiological tests | TXAPA9 219,241,2007 |
| oral/pigeon | lethal dose (50 percent kill): 1330 µg/kg | ASTTA8 (680),157,1979 | |
| oral/quail | lethal dose (50 percent kill): 3160 µg/kg | ASTTA8 (680),157,1979 | |
| oral/rat | lethal dose (50 percent kill): 5 mg/kg | PSSCBG 1,117,1970 | |
| oral/rat | lowest published toxic dose: 0.5 mg/kg | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TXAPA9 219,202,2007 |
| oral/rat | lethal dose (50 percent kill): 8 mg/kg | Behavioral: Convulsions or effect on seizure threshold Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) | EKFAE9 55,51,1992 |
| oral/rat | lowest published toxic dose: 0.5 mg/kg | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 72,305,2003 |
| oral/rat | lowest published toxic dose: 1.5 mg/kg | Brain and Coverings: Other degenerative changes Biochemical: Metabolism (intermediary): Effect on cyclic nucleotides Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TOXID9 12,471,2008 |
| oral/rat | lethal dose (50 percent kill): 8.8 mg/kg | Behavioral: Tremor Lung, Thorax, or Respiration: Acute pulmonary edema | HPV028 -,-,2004 |
| oral/wild bird | lethal dose (50 percent kill): 420 µg/kg | TXAPA9 26,154,1973 | |
| oral/woman | lowest published toxic dose: 1200 µg/kg | Behavioral: Hallucinations, distorted perceptions Lung, Thorax, or Respiration: Dyspnea Skin and Appendages: Other: Sweating | KHZDAN 24,445,1981 |
| skin/mammal (species unspecified) | lethal dose (50 percent kill): 837 mg/kg | Olfaction: Other olfaction effects Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Changes in structure or function of salivary glands | GISAAA 53(2),89,1988 |
| skin/rabbit | lethal dose (50 percent kill): 885 mg/kg | GUCHAZ 6,81,1973 | |
| skin/rabbit | lowest published toxic dose: 2010 mg/kg | Eye: Miosis (pupilliary constriction) Behavioral: Tremor Kidney, Ureter, and Bladder: Hematuria | HPV028 -,-,2004 |
| skin/rat | lethal dose (50 percent kill): 120 mg/kg | WRPCA2 9,119,1970 | |
| skin/wild bird | lethal dose (50 percent kill): 100 mg/kg | TXAPA9 26,154,1973 | |
| subcutaneous/rat | lowest published toxic dose: 1.5 mg/kg | Behavioral: Convulsions or effect on seizure threshold Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 44,204,2005 |
| subcutaneous/rat | lowest published toxic dose: 1.5 mg/kg | Biochemical: Metabolism (intermediary): Other | TOXID9 44,204,2005 |
| subcutaneous/rat | lowest published toxic dose: 1.5 mg/kg | Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Changes in structure or function of salivary glands Biochemical: Metabolism (intermediary): Lipids including transport | TXCYAC 208,13,2005 |
| subcutaneous/rat | lowest published toxic dose: 1.5 mg/kg | Endocrine: Estrogenic Endocrine: Hypoglycemia Nutritional and Gross Metabolic: Body temperature decrease | TOXID9 78,117,2004 |
| subcutaneous/rat | lowest published toxic dose: 1.25 mg/kg | Brain and Coverings: Other degenerative changes Biochemical: Metabolism (intermediary): Effect on mitochondrial function Biochemical: Metabolism (intermediary): Other | TOXID9 1,49,2001 |
| subcutaneous/rat | lowest published toxic dose: 1.5 mg/kg | Peripheral Nerve and Sensation: Fasciculations Musculoskeletal: Other changes Biochemical: Metabolism (intermediary): Effect on cyclic nucleotides | TOXID9 78,309,2004 |
| subcutaneous/rat | lowest published toxic dose: 1.5 mg/kg | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Metabolism (intermediary): Lipids including transport Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation | TOXID9 90,102,2006 |
| subcutaneous/rat | lowest published toxic dose: 1.5 mg/kg | Brain and Coverings: Other degenerative changes Peripheral Nerve and Sensation: Fasciculations Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TXAPA9 219,97,2007 |
| unreported route/mouse | lethal dose (50 percent kill): 5 mg/kg | GISAAA 49(10),23,1984 | |
| unreported route/rabbit | lethal dose (50 percent kill): 885 mg/kg | 30ZDA9 -,192,1971 | |
| unreported route/rat | lethal dose (50 percent kill): 19 mg/kg | GISAAA 49(10),23,1984 | |
| unreported route/rat | lethal dose (50 percent kill): 8 mg/kg | Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) | FATOAO 50,97,1987 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intraperitoneal/mammal (species unspecified) | lowest published toxic dose: 10.5 mg/kg/6W- intermittent | Blood: Other changes | HBPTO* 1,776,2001 |
| intraperitoneal/mouse | lowest published toxic dose: 3 mg/kg/6W- intermittent | Brain and Coverings: Other degenerative changes Liver: Other changes Biochemical: Metabolism (intermediary): Lipids including transport | TXCYAC 38,69,1986 |
| multiple/non-mammalian species | : 50 mg/m3/7D- continuous | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases | TXCYAC 212,107,2005 |
| oral/chicken | lowest published toxic dose: 1960 mg/kg/2W- continuous | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TXAPA9 11,49,1967 |
| oral/Dog | lowest published toxic dose: 4550 mg/kg/1Y- continuous | Blood: Other changes Blood: Changes in erythrocyte (RBC) count Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | RCTOE4 104,35,1988 |
| oral/mouse | lowest published toxic dose: 39 mg/kg/30D- intermittent | Reproductive: Maternal effects: Oogenesis Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in ovarian weight | BECTA6 71,422,2003 |
| oral/mouse | lowest published toxic dose: 10.5 mg/kg/15D- intermittent | Endocrine: Differential effect of sex or castration on observed toxicity Related to Chronic Data: Changes in ovarian weight | TXCYAC 204,87,2004 |
| oral/mouse | lowest published toxic dose: 13686 mg/kg/2Y- continuous | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | RCTOE4 104,35,1988 |
| oral/rabbit | lowest published toxic dose: 0.99 mg/kg/33D- continuous | Immunological Including Allergic: Decrease in humoral immune response | TXAPA9 32,587,1975 |
| oral/rabbit | lowest published toxic dose: 1.71 mg/kg/57D- continuous | Blood: Changes in spleen | TXAPA9 32,587,1975 |
| oral/rabbit | lowest published toxic dose: 1.32 mg/kg/44D- continuous | Immunological Including Allergic: Decreased immune response | TXAPA9 32,587,1975 |
| oral/rat | lowest published toxic dose: 21 mg/kg/30D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS | BCTKAG 14,289,1981 |
| oral/rat | lowest published toxic dose: 3640 mg/kg/2Y- continuous | Brain and Coverings: Other degenerative changes Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | RCTOE4 104,35,1988 |
| oral/rat | lowest published toxic dose: 12 mg/kg/60D- intermittent | Endocrine: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TOXID9 -,193,2008 |
| oral/rat | lowest published toxic dose: 900 mg/kg/24W- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | HPV028 -,-,2004 |
| oral/wild bird | lowest published toxic dose: 71600 µg/kg/7D- continuous | Behavioral: Somnolence (general depressed activity) Behavioral: Food intake (animal) Nutritional and Gross Metabolic: Weight loss or decreased weight gain | AECTCV 11,611,1982 |
| skin/rabbit | lowest published toxic dose: 17 gm/kg/20D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | JJOMDZ 12,16,1970 |
| skin/rat | lowest published toxic dose: 5250 mg/kg/21D- intermittent | Behavioral: Tremor Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TOXID9 -,55,2008 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.1 mg/m3 (inhal, vapor) | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | JAVMA4 164,277,1974 | |
| TOXICOLOGY REVIEW | TOLED5 128,45,2002 | |
| TOXICOLOGY REVIEW | MUREAV 562,77,2004 | |
| TOXICOLOGY REVIEW | MUTAEX 21,93,2006 | |
| TOXICOLOGY REVIEW | NETOX* 26,531,2005 | |
| TOXICOLOGY REVIEW | HTOPA* 1,501,2002 | |
| TOXICOLOGY REVIEW | FEREAC 73,44864,2008 | |
| TOXICOLOGY REVIEW | FEREAC 74,23046,2009 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | Supported | RBREV* -,94,1998 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 0.1 mg/m3, JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 0.1 mg/m3;KZW 0.2 mg/m3, inhal, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 0.1 mg/m3, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 0.1 mg/m3, MAY2011 | |
| Occupational Exposure Limit-FRANCE | VME 0.1 mg/m3, FEB2006 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 0.1 mg/m3, NOV2011 | |
| Occupational Exposure Limit-INDIA | time-weighted average 0.1 mg/m3, JAN1993 | |
| Occupational Exposure Limit-KOREA | time-weighted average 0.1 mg/m3, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 0.1 mg/m3, 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 0.1 mg/m3, JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 0.1 mg/m3, JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 0.1 mg/m3, JUL2005 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 0.1 mg/m3, JAN1999 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 0.1 mg/m3, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 0.1 mg/m3, 2003 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CARBOFURAN-air | 10H time-weighted average 0.1 mg/m3 | NIOSH* DHHS #95-121,1995 |
Status in Federal Agencies
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division