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Registry of Toxic Effects of Chemical Substances (RTECS)

Carbamic acid, methyl-, o-isopropoxyphenyl ester

RTECS #

FC3150000

CAS #

114-26-1

Updated

September 201

Molecular Weight

209.27

Molecular Formula

C11H15NO3

Synonyms

2(1-Methylethoxy)phenol methyl carbamate
2-(1-Methylethoxy)phenol methylcarbamate
2-Isopropoxyphenyl N-methylcarbamate
2-Isopropoxyphenyl-N-methylcarbamat (German)
2-Isopropoxyphenyl-N-methylcarbamate
Arprocarb
BAY 39007
BAY 5122
Bayer 39007
Bayer B 5122
Baygon
Baygon (OSHA)
Blattanex
Blattosep
Carbamic acid, methyl-, 2-(1-methylethoxy)phenyl ester
Chemagro 9010
ENT 25,671
Invisi-Gard
n-2-(1-Methylethoxy)phenyl methyl-carbamate
o-IMPC
o-Isopropoxyphenyl N-methylcarbamate
OMS-33
PHC (carbamate)
PHC 7
Phenol, o-isopropoxy-, methylcarbamate
Propoksuru (Polish)
Propoxur
Propoxur (ACGIH)
Propoxylor
Sendran
Suncide
Tendex
Tugon fliegenkugel
Unden (pesticide)

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisintraperitoneal/hamster250 mg/kgARTODN 58,152,1986
Cytogenetic Analysisovary/hamster0.05 mg/L/1HFCTOD7 45,928,2007
Cytogenetic Analysisovary/hamster0.04 mg/L/2HFCTOD7 45,928,2007
Dominant Lethal Testoral/mouse125 mg/kg/5D-continuousGISAAA 44(7),75,1979
micronucleus testlymphocyte/human50 mg/LMUREAV 232,45,1990
mutation in microorganisms/Salmonella typhimurium250 ng/plate (+enzymatic activation step)RPZHAW 30,81,1979
mutation in microorganisms/Saccharomyes cerevisiae5 ppm (-enzymatic activation step)RSTUDV 6,161,1976
sister chromatid exchangelymphocyte/human50 mg/LMUREAV 232,45,1990
sister chromatid exchangelung/hamster200 mg/LCRNGDP 19,623,1998

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 1600 mg/kg (6-22D preg/15D after birth)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Other postnatal measures or effects		BECTA6 20,624,1978
oral/rat 650 mg/kg (7-19D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemJPFCD2 20,373,1985
oral/mouse 600 mg/kg (7-16D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death		JPFCD2 20,373,1985
oral/mouse 50 mg/kg (7-16D pregnant)Reproductive: Specific developmental abnormalities: Urogenital systemJPFCD2 20,373,1985

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 1440 mg/m3/1H85GYAV -,70,1971
inhalation/rat lethal concentration (50 percent kill): 1440 mg/m3HBPTO* 2,1094,2001
intramuscular/rat lethal dose (50 percent kill): 53 mg/kgBJIMAG 22,317,1965
intraperitoneal/hamster lethal dose (50 percent kill): 500 mg/kgARTODN 58,152,1986
intraperitoneal/mouse lethal dose (50 percent kill): 12 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseJAFCAU 16,561,1968
intraperitoneal/rat lethal dose (50 percent kill): 30 mg/kgBehavioral: General anesthetic

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes		BWHOA6 44,241,1971
intravenous/rabbit lethal dose (50 percent kill): 5 mg/kgLung, Thorax, or Respiration: Other changesTXAPA9 165,27,2000
intravenous/rat lethal dose (50 percent kill): 11 mg/kgBJIMAG 22,317,1965
oral/chicken lethal dose (50 percent kill): 46500 µg/kgBehavioral: Convulsions or effect on seizure thresholdTXAPA9 7,606,1965
oral/Dog lowest published toxic dose: 5 mg/kgBrain and Coverings: Other degenerative changes

Behavioral: Alteration of classical conditioning

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase		HBPTO* 1,697,2001
oral/Dog lowest published toxic dose: 2 mg/kgEye: Other eye effects

Gastrointestinal: Other changes

Skin and Appendages: Other: Sweating		HBPTO* 1,697,2001
oral/duck lethal dose (50 percent kill): 9580 µg/kgTXAPA9 22,556,1972
oral/guinea pig lethal dose (50 percent kill): 40 mg/kgHBPTO* 2,1094,2001
oral/human lowest published toxic dose: 0.36 mg/kgOlfaction: Other olfaction effects

Gastrointestinal: Hypermotility, diarrhea		HBPTO* 1,697,2001
oral/human lowest published toxic dose: 0.36 mg/kgEye: Other eye effects

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase		HBPTO* 2,1097,2001
oral/human lowest published toxic dose: 1.5 mg/kgBehavioral: Headache

Cardiac: Pulse rate increased without fall in BP

Gastrointestinal: Nausea or vomiting		HBPTO* 2,1097,2001
oral/mammal (species unspecified) lethal dose (50 percent kill): 90 mg/kgHPBIA9 21,53,1975
oral/mouse lethal dose (50 percent kill): 37 mg/kgHBPTO* 2,1094,2001
oral/mouse lethal dose (50 percent kill): 23500 µg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation		TOIZAG 17,60,1970
oral/pigeon lethal dose (50 percent kill): 7500 µg/kgASTTA8 (680),157,1979
oral/quail lethal dose (50 percent kill): 28 mg/kgTXAPA9 20,57,1971
oral/rabbit lowest published lethal dose: 30 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Somnolence (general depressed activity)		HBPTO* 1,697,2001
oral/rat lowest published toxic dose: 25 mg/kgBehavioral: Muscle contraction or spasticityHBPTO* 1,697,2001
oral/rat lethal dose (50 percent kill): 41 mg/kgYKYUA6 37,1621,1986
oral/rat lowest published toxic dose: 30 mg/kgBrain and Coverings: Recordings from specific areas of CNSNRTXDN 29,87,2008
oral/rat lowest published toxic dose: 10 mg/kgNutritional and Gross Metabolic: Body temperature decreaseNRTXDN 29,87,2008
oral/rat lowest published toxic dose: 3 mg/kgBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase		NRTXDN 29,87,2008
oral/rat lowest published toxic dose: 0.3 mg/kgBehavioral: Change in motor activity (specific assay)TOXID9 44,397,2005
oral/wild bird lethal dose (50 percent kill): 3800 µg/kgTXAPA9 21,315,1972
oral/woman lowest published lethal dose: 24 mg/kgBehavioral: Coma

Cardiac: Pulse rate decreased with fall in BP

Blood: Change in clotting factors		PGMJAO 63,311,1987
oral/woman lowest published lethal dose: 0.6 mL/kgCardiac: Arrythmias (indlucing changes in conduction)

Blood: Other hemolysis with or without anemia

Nutritional and Gross Metabolic: Changes in: Metabolic acidosis		JEMME* 34,295,2008
skin/mammal (species unspecified) lethal dose (50 percent kill): 800 mg/kgPSTDAN 15(10),37,1981
skin/mouse lethal dose (50 percent kill): >1360 mg/kgYKYUA6 31,711,1980
skin/rabbit lowest published toxic dose: 2000 mg/kgHBPTO* 1,697,2001
skin/rabbit lethal dose (50 percent kill): 500 mg/kgHBPTO* 2,1094,2001
skin/rabbit lowest published toxic dose: 2000 mg/kgBehavioral: Change in motor activity (specific assay)

Behavioral: Muscle contraction or spasticity		HBPTO* 1,697,2001
skin/rat lethal dose (50 percent kill): 800 mg/kgRPZHAW 22,579,1971
subcutaneous/mouse lethal dose (50 percent kill): 11400 µg/kgTOIZAG 17,60,1970
subcutaneous/mouse lowest published lethal dose: 22.2 mg/kgARTODN 76,173,2002
subcutaneous/rat lowest published toxic dose: 10 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands		TXAPA9 219,151,2007
subcutaneous/rat lethal dose (50 percent kill): 56 mg/kgYKYUA6 32,471,1981
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 100 mg/kgGISAAA 41(8),82,1976
unreported route/rat lethal dose (50 percent kill): 100 mg/kg30ZDA9 -,193,1971

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 40 mg/kg/4W- intermittentImmunological Including Allergic: Increase in humoral responseINIMP* 4,1223,2004
intraperitoneal/mouse lowest published toxic dose: 200 mg/kg/4W- intermittentEndocrine: Changes in thymus weight

Blood: Changes in spleen

Immunological Including Allergic: Decrease in humoral immune response		INIMP* 4,1223,2004
intraperitoneal/mouse lowest published toxic dose: 40 mg/kg/28D- intermittentImmunological Including Allergic: Increase in humoral response

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase		INIMP* 4,1223,2004
intraperitoneal/mouse lowest published toxic dose: 200 mg/kg/28D- intermittentEndocrine: Changes in thymus weight

Blood: Changes in spleen

Immunological Including Allergic: Decrease in cellular immune response		INIMP* 4,1223,2004
oral/rat lowest published toxic dose: 255.3 mg/kg/6W- intermittentBehavioral: Change in psychophysiological tests

Liver: Changes in liver weight		EESADV 57,270,2004
oral/rat lowest published toxic dose: 85.1 mg/kg/2W- intermittentBehavioral: Alteration of classical conditioningEESADV 57,270,2004
oral/rat lowest published toxic dose: 864 mg/kg/13W- intermittentGastrointestinal: Other changes

Biochemical: Metabolism (intermediary): Other		KHZDAN 22(6),584,1979
oral/rat lowest published toxic dose: 37500 µg/kg/50D- continuousBrain and Coverings: Recordings from specific areas of CNS

Endocrine: Changes in thymus weight

Biochemical: Metabolism (intermediary): Other proteins		TXAPA9 27,465,1974
oral/rat lowest published toxic dose: 180 mg/kg/30D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)		BECTA6 23,438,1979
oral/rat lowest published toxic dose: 1000 mg/kg/50D- continuousBehavioral: Change in psychophysiological testsHBPTO* 2,1100,2001
oral/rat lowest published toxic dose: 238.28 mg/kg/4W- intermittentEndocrine: Changes in thymus weight

Blood: Changes in erythrocyte (RBC) count		TXCYAC 178,161,2002
oral/rat lowest published toxic dose: 238 mg/kg/4W- intermittentLiver: Changes in liver weight

Endocrine: Changes in adrenal weight		TXCYAC 178,161,2002
oral/rat lowest published toxic dose: 714 mg/kg/12W- intermittentLiver: Changes in liver weight

Endocrine: Changes in adrenal weight

Endocrine: Changes in thymus weight		TXCYAC 178,161,2002
subcutaneous/rat lowest published toxic dose: 70 mg/kg/7D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase		TXAPA9 219,151,2007

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.5 mg/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWRREVAH 63,1,1976
TOXICOLOGY REVIEWNEJMAG 342,186,2000
TOXICOLOGY REVIEWNETOX* 26,531,2005
TOXICOLOGY REVIEWNETOX* 26,573,2005
TOXICOLOGY REVIEWJTPAE7 19,1,2006
TOXICOLOGY REVIEWHUTOX* -,683,1996
TOXICOLOGY REVIEWHETOEA 26,321,2007
TOXICOLOGY REVIEWNBREV* 9,479,1985
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,203,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.5 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.5 mg/m3, inhal, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.5 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.5 mg/m3, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.5 mg/m3, short term exposure limit 1.5 mg/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 0.5 mg/m3, FEB2006
Occupational Exposure Limit-GERMANYMAK 2 mg/m3, inhal, 2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.5 mg/m3, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.5 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.05 mg/m3;short term exposure limit 2 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.5 mg/m3, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 0,5 mg/m3, JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.5 mg/m3, MAC(short term exposure limit) 2 mg/m3, JAN1999
Occupational Exposure Limit-SWITZERLANDMAK-week 0.5 mg/m3, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.5 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.5 mg/m3;short term exposure limit 2 mg/m3, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PROPOXUR-air10H time-weighted average 0.5 mg/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code M1931; Number of Industries 15; Total Number of Facilities 2701; Number of Occupations 16; Total Number of Employees Exposed 27304; Total Number of Female Employees Exposed 4206
National Occupational Hazard Survey 1974Hazard Code M1931; Number of Industries 18; Total Number of Facilities 2519; Number of Occupations 14; Total Number of Employees Exposed 18098

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay
EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
On EPA IRIS database

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