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Registry of Toxic Effects of Chemical Substances (RTECS)

Clay (kaolin)

RTECS #

GF1670500

CAS #

1332-58-7

Updated

September 201

Molecular Weight

N/R

Molecular Formula

N/R

Synonyms

Altowhites
Argilla
Bentone
China clay
Emathlite
Fitrol
Fitrol desiccite 25
Glomax
Hydrite
Kaolin
Kaolin (ACGIH:OSHA)
Kaopaous
Kaophills-2
Langford
Mcnamee
Parclay
Porcelain clay
Snow tex

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 590 gm/kg (37D prior to copulation/1-22D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)JONUAI 107,2020,1977
oral/rat 370 gm/kg (37D prior to copulation/1-22D pregnant)Reproductive: Other effects on female

Reproductive: Effects on newborn: Other neonatal measures or effects		JONUAI 107,2020,1977

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intracerebral/rat lowest published toxic dose: 125 mg/kg/2MBrain and Coverings: Changes in cerebral spinal fluid

Brain and Coverings: Other degenerative changes

Immunological Including Allergic: Increase in cellular immune response		IJNUB7 92,9,1997
intrapleural/guinea pig lowest published toxic dose: 150 mg/kgLung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)INHEAO 19,85,1981
intratracheal/guinea pig lowest published toxic dose: 150 mg/kg/2MLung, Thorax, or Respiration: Fibrosis (interstitial)INDHE* 19,85,1981

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/hamster lowest published toxic concentration: 30 mg/m3/72W- intermittentLung, Thorax, or Respiration: Fibrosis (interstitial)

Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Tumors		8COLD* 1,480,1993
inhalation/hamster lowest published toxic concentration: 30 mg/m3/72W- intermittentLung, Thorax, or Respiration: Fibrosis (interstitial)

Lung, Thorax, or Respiration: Tumors		EPASR* 89-900000360
inhalation/hamster lowest published toxic concentration: 30 mg/m3/24W- intermittentLung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Fibrosis (interstitial)		EVHPAZ 102,207,1994
inhalation/hamster lowest published toxic concentration: 30 mg/m3/48W- intermittentLung, Thorax, or Respiration: Fibrosis (interstitial)

Lung, Thorax, or Respiration: Tumors		INHTE5 7,503,1995
inhalation/rat lowest published toxic concentration: 30 mg/m3/96W- intermittentLung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Tumors		EVHPAZ 102,207,1994
inhalation/rat lowest published toxic concentration: 30 mg/m3/72W- intermittentLung, Thorax, or Respiration: TumorsEPASR* 89-900000360
inhalation/rat lowest published toxic concentration: 30 mg/m3/48W- intermittentLung, Thorax, or Respiration: Fibrosis (interstitial)EPASR* 89-900000360
inhalation/rat lowest published toxic concentration: 300 mg/m3/12W- intermittentLung, Thorax, or Respiration: Other changes17IPC* -,897,1990
inhalation/rat lowest published toxic concentration: 30 mg/m3/96W- intermittentLung, Thorax, or Respiration: Fibrosis (interstitial)

Lung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Tumors		8COLD* 1,480,1993
inhalation/rat lowest published toxic concentration: 9 mg/m3/96W- intermittentLung, Thorax, or Respiration: Fibrosis (interstitial)8COLD* 1,480,1993
oral/rat lowest published toxic dose: 370 gm/kg/37D- intermittentBlood: Normocytic anemia

Blood: Other changes

Blood: Changes in erythrocyte (RBC) count		JONUAI 107,2020,1977

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 2 mg/m3 (resp)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWIJTOFN 22,37,2003
TOXICOLOGY REVIEWMUREAV 727,72,2011
TOXICOLOGY REVIEWMUREAV 727,72,2011

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARDNUISANCE PARTICULATESDTLWS* 3,21,1973
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-BELGIUMtime-weighted average 2 mg/m3 (resp. dust), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 2 mg/m3 (respirable), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 2 mg/m3, resp. dust, NOV2011
Occupational Exposure Limit-FRANCEVME 10 mg/m3, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 2 mg/m3 (resp. dust), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 10 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 10 mg/m3;short term exposure limit 20 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 10 mg/m3 (inspirable dust), JAN2002
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 2 mg/m3 (respirable dust), JAN2002
Occupational Exposure Limit-PERUtime-weighted average 2 mg/m3, JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 3 mg/m3, resp, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 10 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 2 mg/m3 (resp. dust), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 5 mg/m3, respirable fractionCFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 5 mg/m3, respirable fractionCFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 5 mg/m3, respirable fractionCFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO KAOLIN, respirable fraction-air10H time-weighted average 5 mg/m3NIOSH* DHHS #92-100,1992
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO KAOLIN, total dust-air10H time-weighted average 10 mg/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code X1959; Number of Industries 1; Total Number of Facilities 3; Number of Occupations 1; Total Number of Employees Exposed 17
National Occupational Exposure Survey 1983Hazard Code X6880; Number of Industries 23; Total Number of Facilities 1734; Number of Occupations 24; Total Number of Employees Exposed 25166; Total Number of Female Employees Exposed 3162
National Occupational Exposure Survey 1983Hazard Code X9449; Number of Industries 1; Total Number of Facilities 7; Number of Occupations 2; Total Number of Employees Exposed 1354
National Occupational Exposure Survey 1983Hazard Code X9507; Number of Industries 1; Total Number of Facilities 62; Number of Occupations 1; Total Number of Employees Exposed 125
National Occupational Exposure Survey 1983Hazard Code 41775; Number of Industries 240; Total Number of Facilities 43700; Number of Occupations 156; Total Number of Employees Exposed 745593; Total Number of Female Employees Exposed 114032
National Occupational Hazard Survey 1974Hazard Code 41775; Number of Industries 111; Total Number of Facilities 14181; Number of Occupations 88; Total Number of Employees Exposed 155396

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

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