Registry of Toxic Effects of Chemical Substances (RTECS)
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m-Cresol
RTECS #
GO6125000CAS #
108-39-4Updated
September 201Molecular Weight
108.15Molecular Formula
C7H8OSynonyms
1-Hydroxy-3-methylbenzene3-Cresol
3-Hydroxytoluene
3-Methylphenol
Cresol
m-Cresol (ACGIH:OSHA)
m-Cresole
m-Cresylic acid
m-Hydroxytoluene
Mixture of meta and para-cresol (59%:41%
m-Kresol
m-Methylphenol
m-Oxytoluene
MPCRE)
m-Toluol
o-Cresol
Phenol, 3-methyl- (9CI)
RCRA waste number U052
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| DNA inhibition | HeLa cell/human | 10 µmol/L/4H | BECTA6 32,220,1984 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/rat | 2100 mg/kg (multigeneration) | Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) | TOXID9 12,198,1992 |
| oral/rat | 1400 mg/kg (multigeneration) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | TOXID9 12,198,1992 |
| oral/rat | 4500 mg/kg (6-15D pregnant) | Reproductive: Other effects on female | HPV299 -,-,2002 |
| oral/rabbit | 650 mg/kg (6-18D pregnant) | Reproductive: Other effects on female Reproductive: Effects on fertility: Abortion | HPV299 -,-,2002 |
| oral/rabbit | 3900 mg/kg (6-18D pregnant) | Reproductive: Other effects on female Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) Reproductive: Specific developmental abnormalities: Musculoskeletal system | HPV299 -,-,2002 |
| subcutaneous/rabbit | 390 mg/kg (6-18D pregnant) | Reproductive: Other effects on female Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | HPV299 -,-,2002 |
| subcutaneous/rabbit | 134 gm/kg (6-18D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | OYYAA2 16,1191,1978 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| skin/mouse | lowest published toxic dose: 2280 mg/kg/20W- intermittent | Tumorigenic: Neoplastic by RTECS criteria Skin and Appendages: Tumors | CNREA8 19,413,1959 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | lethal concentration (50 percent kill): 58 mg/m3 | Behavioral: Tetany Lung, Thorax, or Respiration: Acute pulmonary edema Kidney, Ureter, and Bladder: Hematuria | VCVGK* -,207,1994 |
| intraperitoneal/Dog | lowest published lethal dose: 100 mg/kg | VCVGK* -,207,1994 | |
| intraperitoneal/guinea pig | lowest published lethal dose: 100 mg/kg | HBAMAK 4,1361,1935 | |
| intraperitoneal/mouse | lethal dose (50 percent kill): 168 mg/kg | VCVGK* -,207,1994 | |
| intravenous/Dog | lowest published lethal dose: 150 mg/kg | VCVGK* -,207,1994 | |
| intravenous/rabbit | lowest published lethal dose: 280 mg/kg | VCVGK* -,207,1994 | |
| oral/mouse | lethal dose (50 percent kill): 600 mg/kg | Cardiac: Other changes Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGK* -,207,1994 |
| oral/mouse | lethal dose (50 percent kill): 828 mg/kg | GTPZAB 18(2),58,1974 | |
| oral/rabbit | lowest published lethal dose: 1400 mg/kg | JPETAB 80,233,1944 | |
| oral/rabbit | lethal dose (50 percent kill): 1400 mg/kg | Cardiac: Other changes Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGK* -,207,1994 |
| oral/rat | lethal dose (50 percent kill): 825 mg/kg | Kidney, Ureter, and Bladder: Hematuria Skin: After systemic exposure: Dermatitis, other | WDZAEK 9,108,1995 |
| oral/rat | lethal dose (50 percent kill): 242 mg/kg | Cardiac: Other changes Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGK* -,207,1994 |
| skin/rabbit | lethal dose (50 percent kill): 620 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Tetany | VCVGK* -,207,1994 |
| skin/rat | lethal dose (50 percent kill): 1000 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Tetany | VCVGK* -,207,1994 |
| skin/rat | lethal dose (50 percent kill): 1100 mg/kg | GTPZAB 18(2),58,1974 | |
| subcutaneous/cat | lowest published lethal dose: 180 mg/kg | VCVGK* -,207,1994 | |
| subcutaneous/frog | lowest published lethal dose: 250 mg/kg | HBAMAK 4,1361,1935 | |
| subcutaneous/guinea pig | lowest published lethal dose: 300 mg/kg | VCVGK* -,207,1994 | |
| subcutaneous/mouse | lowest published lethal dose: 450 mg/kg | VCVGK* -,207,1994 | |
| subcutaneous/rabbit | lethal dose (50 percent kill): 2050 mg/kg | VCVGK* -,207,1994 | |
| subcutaneous/rabbit | lowest published lethal dose: 500 mg/kg | HBAMAK 4,1361,1935 | |
| subcutaneous/rat | lowest published lethal dose: 900 mg/kg | VCVGK* -,207,1994 | |
| subcutaneous/rat | lethal dose (50 percent kill): 300 mg/kg | TOXID9 66,266,2002 | |
| unreported route/mouse | lethal dose (50 percent kill): 600 mg/kg | GTPPAF 8,145,1972 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/mouse | lowest published toxic dose: 101 gm/kg/28D- continuous | Brain and Coverings: Changes in brain weight Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** PB92-174242 |
| oral/mouse | lowest published toxic dose: 867000 mg/kg/2Y- continuous | Lung, Thorax, or Respiration: Other changes Gastrointestinal: Tumors Tumorigenic: Tumor types after systemic administration not seen spontaneously | TOXID9 -,106,2008 |
| oral/mouse | lowest published toxic dose: 33600 mg/kg/28D- intermittent | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | HPV299 -,-,2002 |
| oral/rat | lowest published toxic dose: 42 gm/kg/28D- continuous | Brain and Coverings: Changes in brain weight Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight | NTIS** PB92-174242 |
| oral/rat | lowest published toxic dose: 14000 mg/kg/28D- intermittent | Liver: Changes in liver weight | HPV299 -,-,2002 |
| oral/rat | lowest published toxic dose: 42000 mg/kg/28D- intermittent | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HPV299 -,-,2002 |
| oral/rat | lowest published toxic dose: 40950 mg/kg/13W- intermittent | Lung, Thorax, or Respiration: Dyspnea Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | HPV299 -,-,2002 |
| oral/rat | lowest published toxic dose: 1800 mg/kg/18D- intermittent | Behavioral: Tremor | TOXID9 72,390,2003 |
| oral/rat | lowest published toxic dose: 5400 mg/kg/18D- intermittent | Lung, Thorax, or Respiration: Respiratory depression Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TOXID9 72,390,2003 |
| oral/rat | lowest published toxic dose: 28 gm/kg/28D- intermittent | Behavioral: Tremor Lung, Thorax, or Respiration: Respiratory depression Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TOXID9 72,390,2003 |
| oral/rat | lowest published toxic dose: 5400 mg/kg/18D- intermittent | Brain and Coverings: Changes in brain weight Lung, Thorax, or Respiration: Respiratory depression Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) | JTSCDR 28,59,2003 |
| oral/rat | lowest published toxic dose: 1800 mg/kg/18D- intermittent | Liver: Changes in liver weight | JTSCDR 28,59,2003 |
| oral/rat | lowest published toxic dose: 400 mg/kg/4D- intermittent | Behavioral: Tremor | JTSCDR 28,59,2003 |
| oral/rat | lowest published toxic dose: 1200 mg/kg/4D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JTSCDR 28,59,2003 |
| oral/rat | lowest published toxic dose: 5400 mg/kg/18D- intermittent | Brain and Coverings: Changes in brain weight Lung, Thorax, or Respiration: Respiratory depression Liver: Changes in liver weight | JTSCDR 28,59,2003 |
| oral/rat | lowest published toxic dose: 3000 mg/kg/10D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JTSCDR 28,59,2003 |
| oral/rat | lowest published toxic dose: 14000 mg/kg/14D- intermittent | Behavioral: Tremor Kidney, Ureter, and Bladder: Changes in kidney weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JTSCDR 28,59,2003 |
| oral/rat | lowest published toxic dose: 14000 mg/kg/14D- intermittent | Behavioral: Tremor Gastrointestinal: Changes in structure or function of salivary glands Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JTSCDR 28,59,2003 |
| oral/rat | lowest published toxic dose: 7000 mg/kg/14D- intermittent | Liver: Changes in liver weight | JTSCDR 28,59,2003 |
| oral/rat | lowest published toxic dose: 7000 mg/kg/14D- intermittent | Liver: Changes in liver weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | JTSCDR 28,59,2003 |
| oral/rat | lowest published toxic dose: 28000 mg/kg/28D- intermittent | Brain and Coverings: Changes in brain weight Behavioral: Fluid intake Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | JTSCDR 28,59,2003 |
| oral/rat | lowest published toxic dose: 28000 mg/kg/28D- intermittent | Brain and Coverings: Changes in brain weight Behavioral: Fluid intake Kidney, Ureter, and Bladder: Changes in kidney weight | JTSCDR 28,59,2003 |
| oral/rat | lowest published toxic dose: 657000 mg/kg/2Y- continuous | Lung, Thorax, or Respiration: Other changes Kidney, Ureter, and Bladder: Other changes | TOXID9 -,106,2008 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 20 mg/m3 (inhal, vapor, skin) | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | MUREAV 47,75,1978 | |
| TOXICOLOGY REVIEW | ENTOX* -,678,2005 | |
| TOXICOLOGY REVIEW | HUTOX* -,259,1996 | |
| TOXICOLOGY REVIEW | MUREAV 741,32,2012 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | RED Completed | RBREV* -,305,1998 |
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 5 ppm (22 mg/m3) | DTLVS* 3,61,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 5 ppm (22 mg/m3), JUL2008 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 5 ppm (22 mg/m3), Skin, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 5 ppm (22 mg/m3), skin, EC-limit, MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 5 ppm (22 mg/m3), short term exposure limit 10 ppm (45 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 5 ppm (22 mg/m3), FEB2006 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 5 ppm (22 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-JAPAN | Occupational Exposure Limit 5 ppm (22 mg/m3), skin, MAY2012 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 5 ppm (22 mg/m3), skin, JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 5 ppm (22 mg/m3), JAN1999 | |
| Occupational Exposure Limit-SWEDEN | time-weighted average 1 ppm (4.5 mg/m3);short term exposure limit 2 ppm (9 mg/m3), Skin, JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | ceiling concentration 5 ppm (22 5 mg/m3), skin, JAN2011 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 5 ppm (22 mg/m3) (skin) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 5 ppm (22 mg/m3) (skin) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 5 ppm (22 mg/m3) (skin) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 5 ppm (22 mg/m3) (skin) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO m-CRESOL-air | 10H time-weighted average 2.3 ppm | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 84497; Number of Industries 5; Total Number of Facilities 144; Number of Occupations 11; Total Number of Employees Exposed 5615; Total Number of Female Employees Exposed 1174 | |
| National Occupational Hazard Survey 1974 | Hazard Code 84497; Number of Industries 16; Total Number of Facilities 1317; Number of Occupations 20; Total Number of Employees Exposed 11161 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE | FEREAC 47,26992,82 |
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| EPA TSCA Section 8(d) unpublished health/safety studies | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
| NIOSH Analytical Method, 1994: Cresol (all isomers) and phenol, 2546 | |
| NIOSH Analytical Method, 1996: Volatile organic compound, 2549 | |
| NTP Toxicity studies, RPT# TOX-09, October 2000 | |
| On EPA IRIS database |
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division