Registry of Toxic Effects of Chemical Substances (RTECS)
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p-Cresol, 2,6-di-tert-butyl-
RTECS #
GO7875000CAS #
128-37-0; 58500-82-6Updated
September 201Molecular Weight
220.39Molecular Formula
C15H24OSynonyms
2,6-Bis(1,1-dimethylethyl)-4-methylphenol2,6-Di-terc.butyl-p-kresol (Czech)
2,6-Di-tert-butyl-1-hydroxy-4-methylbenzene
2,6-Di-tert-butyl-4-methylphenol
2,6-Di-tert-butyl-p-cresol
2,6-Di-tert-butyl-p-cresol (ACGIH)
2,6-Di-tert-butyl-p-methylphenol
3,5-Di-tert-butyl-4-hydroxytoluene
4-Hydroxy-3,5-di-tert-butyltoluene
4-Methyl-2,6-di-terc. butylfenol (Czech)
4-Methyl-2,6-di-tert-butylphenol
Advastab 401
Agidol
Agidol 1
Alkofen BP
Antioxidant 29
Antioxidant 30
Antioxidant 4
Antioxidant 4K
Antioxidant DBPC
Antioxidant KB
Antrancine 8
AO 29
AO 4K
BHT
BHT (food grade)
BUKS
Butylated hydroxytoluene
Butylhydroxytoluene
Butylohydroksytoluenu (Polish)
CAO 1
CAO 3
Catalin cao-3
Chemanox 11
Dalpac
DBMP
DBPC
DBPC (technical grade)
Deenax
Dibunol
Dibutylated hydroxytoluene
Impruvol
Ionol
Ionol (antioxidant)
Ionol 1
Ionol CP
Ionole
Kerabit
Methyldi-tert-butylphenol
NCI-C03598
Nocrac 200
Nonox TBC
P 21
Parabar 441
Paranox 441
Phenol, 2,6-bis(1,1-dimethylethyl)-4-methyl- (9CI)
Stavox
Sumilizer BHT
Sustane BHT
Swanox BHT
Tenamene 3
Tenox BHT
Topanol
Topanol O
Topanol OC
Toxolan P
Vanlube PC
Vanlube PCX
Vianol
Vulkanox KB
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /rabbit | 100 mg/24H | moderate | 85JCAE -,229,1986 |
| skin /human | 500 mg/48H | mild | AMIHBC 5,311,1952 |
| skin /rabbit | 500 mg/48H | moderate | AMIHBC 5,311,1952 |
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| Cytogenetic Analysis | ovary/hamster | 100 µg/L | MUREAV 345,73,1995 |
| DNA Damage | oral/mouse | 100 mg/kg | MUREAV 519,103,2002 |
| DNA Damage | oral/rat | 1400 mg/kg/2D | HPV260 -,-,2001 |
| DNA Damage | oral/rat | 1400 mg/kg | FCTOD7 25,603,1987 |
| DNA inhibition | HeLa cell/human | 500 µmol/L | CRNGDP 13,2389,1992 |
| DNA inhibition | lymphocyte/human | 20 µmol/L | BBRCA9 80,963,1978 |
| DNA inhibition | intraperitoneal/mouse | 250 mg/kg | CBINA8 19,279,1977 |
| Dominant Lethal Test | oral/mouse | 12 gm/kg/10W-continuous | NTIS** PB278-026 |
| Dominant Lethal Test | oral/rat | 5460 mg/kg/10W-continuous | ENMUDM 8,357,1986 |
| mutation in mammalian somatic cells | lymphocyte/mouse | 6 mg/L | EMMUEG 11,91,1988 |
| mutation in microorganisms | lymphocyte/mouse | 6 mg/L (+enzymatic activation step) | EMMUEG 11,91,1988 |
| other mutation test systems | oral/mouse | 500 mg/kg | MUREAV 343,157,1995 |
| specific locus test | other cell types/mouse | 45 µmol/L | MUREAV 608,29,2006 |
| sperm morphology | intraperitoneal/mouse | 350 mg/kg/5D- intermittent | CMMUAO 5,257,1978 |
| Unscheduled DNA Synthesis | oral/rat | 16800 mg/kg/4W-continuous | TXAPA9 99,37,1989 |
| Unscheduled DNA Synthesis | liver/rat | 100 pmol/L | CRNGDP 5,1547,1984 |
| Unscheduled DNA Synthesis | intraperitoneal/rat | 1200 mg/kg/3D-continuous | DANKAS 287,371,1986 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/rat | 6 gm/kg (13W male/13W pre-3W after birth) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | FCTOD7 24,1,1986 |
| oral/rat | 18 gm/kg (2W male/2W pre-3W after birth) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Behavioral | FCTXAV 19,153,1981 |
| oral/rat | 9 gm/kg (2W male/2W pre-3W after birth) | Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) | FCTXAV 19,153,1981 |
| oral/rat | 35 gm/kg (10W male) | Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) | ENMUDM 8,357,1986 |
| oral/mouse | 43800 mg/kg (52D prior to copulation/1-21D pregnant) | Reproductive: Maternal effects: Parturition Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | FCTXAV 3,371,1965 |
| oral/mouse | 12600 mg/kg (1-21D pregnant) | Reproductive: Effects on newborn: Behavioral | FEPRA7 31,596,1972 |
| oral/mouse | 1200 mg/kg (9D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system | TRENAF 28(2),45,1977 |
| oral/rat | 28000 mg/kg (multigeneration) | Reproductive: Other effects on female Reproductive: Effects on newborn: Biochemical and metabolic | HPV260 -,-,2001 |
| oral/rat | 3300 mg/kg (7-17D pregnant) | Reproductive: Effects on newborn: Physical | HPV260 -,-,2001 |
| oral/mouse | 1200 mg/kg (9D pregnant) | Reproductive: Other effects on female | HPV260 -,-,2001 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/mouse | lowest published toxic dose: 435 mg/kg/69W- continuous | Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors Gastrointestinal: Tumors | FCTXAV 12,367,1974 |
| oral/mouse | toxic dose: 1423 mg/kg/43W- continuous | Tumorigenic: Neoplastic by RTECS criteria Liver: Tumors | TXCYAC 38,151,1986 |
| oral/mouse | lowest published toxic dose: 1200 mg/kg/3W- intermittent | Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors Tumorigenic: Tumor types after systemic administration not seen spontaneously | CALEDQ 145,101,1999 |
| oral/rat | lowest published toxic dose: 134 gm/kg/32W- continuous | Tumorigenic: Carcinogenic by RTECS criteria Kidney, Ureter, and Bladder: Bladder tumors Tumorigenic: Cells (cultured) transformed | CRNGDP 4,895,1983 |
| oral/rat | toxic dose: 247 gm/kg | Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors | FCTOD7 24,1121,1986 |
| oral/rat | toxic dose: 963 gm/kg | Tumorigenic: Carcinogenic by RTECS criteria Gastrointestinal: Tumors | FCTOD7 24,1071,1986 |
| oral/rat | toxic dose: 247 gm/kg/3Y- continuous | Tumorigenic: Carcinogenic by RTECS criteria Reproductive: Tumorigenic effects: Transplacental tumorigenesis Liver: Tumors | FCTOD7 24,1,1986 |
| oral/rat | toxic dose: 247 gm/kg/3Y- continuous | Tumorigenic: Neoplastic by RTECS criteria Reproductive: Tumorigenic effects: Ovarian tumors | FCTOD7 24,1,1986 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| In Vitro/Human, lung tumor | Inhibitor Concentration (50 percent kill): 0.15 mmol/L/24H | In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc. | TIVIEQ 1,85,1987 |
| In Vitro/Rat, lung | Inhibitor Concentration (50 percent kill): 4.04 mmol/L/24H | In Vitro Toxicity Studies: Cell counting | TIVIEQ 18,79,2004 |
| intraperitoneal/mouse | lowest published toxic dose: 150 mg/kg | Lung, Thorax, or Respiration: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes Biochemical: Metabolism (intermediary): Other proteins | CRTOEC 21,1631,2008 |
| intraperitoneal/mouse | lethal dose (50 percent kill): 138 mg/kg | Lung, Thorax, or Respiration: Acute pulmonary edema Blood: Hemorrhage | IJTOFN 21,19,2002 |
| intraperitoneal/mouse | lethal dose (50 percent kill): 138 mg/kg | ENTOX* -,365,2005 | |
| intraperitoneal/mouse | lethal dose (50 percent kill): 138 mg/kg | Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Lung, Thorax, or Respiration: Other changes Blood: Hemorrhage | TXAPA9 61,475,1981 |
| intraperitoneal/mouse | lowest published toxic dose: 100 mg/kg | Lung, Thorax, or Respiration: Fibrosis (interstitial) Lung, Thorax, or Respiration: Changes in lung weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | VCVGK* -,212,1994 |
| intraperitoneal/rat | lethal dose (50 percent kill): 8 gm/kg | IJTOFN 21,19,2002 | |
| intraperitoneal/rat | lowest published toxic dose: 10 mg/kg | Liver: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Metabolism (intermediary): Lipids including transport | FATOAO 55,34,1992 |
| intraperitoneal/rat | lowest published toxic dose: 1 mg/kg | Immunological Including Allergic: Other immediate (humoral): uticaria, allergic rhinitis, serum sickness (multiple organ involvement) | TXAPA9 223,164,2007 |
| intravenous/mouse | lethal dose (50 percent kill): 180 mg/kg | Behavioral: Sleep | JMCMAR 23,1350,1980 |
| oral/cat | lowest published lethal dose: 940 mg/kg | Gastrointestinal: Hypermotility, diarrhea Behavioral: Tremor Lung, Thorax, or Respiration: Respiratory depression | AMIHAB 11,93,1955 |
| oral/cat | lowest published lethal dose: 940 mg/kg | VCVGK* -,212,1994 | |
| oral/guinea pig | lethal dose (50 percent kill): 10700 mg/kg | Gastrointestinal: Hypermotility, diarrhea Behavioral: Tremor Lung, Thorax, or Respiration: Respiratory depression | AMIHAB 11,93,1955 |
| oral/guinea pig | lethal dose (50 percent kill): 10700 mg/kg | ENTOX* -,365,2005 | |
| oral/mouse | lethal dose (50 percent kill): 1040 mg/kg | ENTOX* -,365,2005 | |
| oral/mouse | lethal dose (50 percent kill): 650 mg/kg | Behavioral: Tremor Behavioral: Ataxia Lung, Thorax, or Respiration: Other changes | IJTOFN 21,19,2002 |
| oral/mouse | lowest published toxic dose: 50 mg/kg | Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | EKFAE9 62,56,1999 |
| oral/mouse | lethal dose (50 percent kill): 650 mg/kg | Behavioral: Tremor Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion | SRTCAC 36(1-4),10,1989 |
| oral/rabbit | lowest published lethal dose: 2100 mg/kg | Gastrointestinal: Hypermotility, diarrhea Behavioral: Tremor Lung, Thorax, or Respiration: Respiratory depression | AMIHAB 11,93,1955 |
| oral/rabbit | lethal dose (50 percent kill): 2100 mg/kg | VCVGK* -,212,1994 | |
| oral/rabbit | lowest published lethal dose: 2000 mg/kg | VCVGK* -,212,1994 | |
| oral/rat | lowest published toxic dose: 25 mg/kg | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes | EKFAE9 62,56,1999 |
| oral/rat | lethal dose (50 percent kill): 890 mg/kg | ENTOX* -,365,2005 | |
| oral/woman | lowest published toxic dose: 80 mg/kg | Behavioral: Coma Gastrointestinal: Gastritis Gastrointestinal: Nausea or vomiting | NEJMAG 314,648,1986 |
| rectal/mouse | lowest published toxic dose: 50 mg/kg | Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | EKFAE9 62,56,1999 |
| rectal/rat | lowest published toxic dose: 25 mg/kg | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes | EKFAE9 62,56,1999 |
| skin/rat | lethal dose (50 percent kill): >2000 mg/kg | HPV260 -,-,2001 | |
| subcutaneous/mouse | lethal dose (50 percent kill): 650 mg/kg | ENTOX* -,365,2005 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intraperitoneal/guinea pig | lowest published toxic dose: 570 mg/kg/3D- intermittent | Blood: Change in clotting factors | VCVGK* -,212,1994 |
| intraperitoneal/hamster | lowest published toxic dose: 1140 mg/kg/3D- intermittent | Brain and Coverings: Changes in circulation Behavioral: Tremor | VCVGK* -,212,1994 |
| intraperitoneal/mouse | lowest published toxic dose: 1750 mg/kg/1W- intermittent | Gastrointestinal: Tumors Liver: Tumors Kidney, Ureter, and Bladder: Bladder tumors | VCVGK* -,213,1994 |
| intraperitoneal/mouse | lowest published toxic dose: 600 mg/kg/4W- intermittent | Lung, Thorax, or Respiration: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes Biochemical: Metabolism (intermediary): Other proteins | CRTOEC 21,1631,2008 |
| intraperitoneal/mouse | lowest published toxic dose: 750 mg/kg/3W- intermittent | Lung, Thorax, or Respiration: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TXCYAC 169,1,2001 |
| intraperitoneal/mouse | lowest published toxic dose: 750 mg/kg/3W- intermittent | Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TXCYAC 169,1,2001 |
| intraperitoneal/mouse | lowest published toxic dose: 735 mg/kg/4W- intermittent | Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | JNCIEQ 97,1778,2005 |
| intraperitoneal/rabbit | lowest published toxic dose: 480 mg/kg/4D- intermittent | Cardiac: Other changes Biochemical: Metabolism (intermediary): Lipids including transport | FATOAO 55,19,1992 |
| oral/hamster | lowest published toxic dose: 1596 mg/kg/14D- continuous | Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases | FCTOD7 34,595,1996 |
| oral/monkey | lowest published toxic dose: 14 gm/kg/4W- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases | FCTXAV 10,769,1972 |
| oral/mouse | lowest published toxic dose: 13500 mg/kg/18D- intermittent | Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes | FCTXAV 3,417,1965 |
| oral/mouse | lowest published toxic dose: 48600 mg/kg/30D- continuous | Lung, Thorax, or Respiration: Changes in lung weight Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) | FCTOD7 30,89,1992 |
| oral/mouse | lowest published toxic dose: 10.08 mg/kg/1W- continuous | Brain and Coverings: Changes in circulation Blood: Hemorrhage Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | VCVGK* -,212,1994 |
| oral/mouse | lowest published toxic dose: 2000 mg/kg/4D- intermittent | Liver: Multiple effects Kidney, Ureter, and Bladder: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | VCVGK* -,212,1994 |
| oral/rat | lowest published toxic dose: 6.3 mg/kg/1W- continuous | Brain and Coverings: Changes in circulation Blood: Hemorrhage Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | VCVGK* -,212,1994 |
| oral/rat | lowest published toxic dose: 547.5 mg/kg/2Y- continuous | Brain and Coverings: Changes in brain weight Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | VCVGK* -,213,1994 |
| oral/rat | lowest published toxic dose: 1200 mg/kg/3D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases | FATOAO 50,81,1987 |
| oral/rat | lowest published toxic dose: 840 mg/kg/14D- intermittent | Cardiac: Other changes Biochemical: Metabolism (intermediary): Lipids including transport | EKFAE9 56,47,1993 |
| oral/rat | lowest published toxic dose: 5185 mg/kg/4W- continuous | Liver: Other changes Liver: Changes in liver weight | TOLED5 87,103,1996 |
| oral/rat | lowest published toxic dose: 109 gm/kg/2Y- continuous | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood: Changes in erythrocyte (RBC) count Blood: Changes in leukocyte (WBC) count | FCTXAV 19,147,1981 |
| oral/rat | lowest published toxic dose: 27 gm/kg/90D- continuous | Liver: Changes in liver weight Endocrine: Evidence of thyroid hyperfunction Endocrine: Changes in thyroid weight | TOLED5 10,239,1982 |
| oral/rat | lowest published toxic dose: 37800 mg/kg/6W- continuous | Liver: Changes in liver weight Endocrine: Changes in adrenal weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | AJEBAK 39,353,1961 |
| oral/rat | lowest published toxic dose: 5600 mg/kg/16W- continuous | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Other changes in urine composition | FCTXAV 3,433,1965 |
| oral/rat | lowest published toxic dose: 275 mg/kg/26W- continuous | Liver: Changes in liver weight Skin and Appendages: Other: Hair Nutritional and Gross Metabolic: Weight loss or decreased weight gain | AJEBAK 37,533,1959 |
| oral/rat | lowest published toxic dose: 112 gm/kg/80W- continuous | Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical: Metabolism (intermediary): Other proteins | TXCYAC 7,289,1977 |
| oral/rat | lowest published toxic dose: 5040 mg/kg/7D- continuous | Liver: Changes in liver weight Blood: Changes in erythrocyte (RBC) count Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | APTOA6 49,14,1981 |
| oral/rat | lowest published toxic dose: 350 mg/kg/7D- intermittent | Gastrointestinal: Other changes Liver: Other changes | FATOAO 47,87,1984 |
| oral/rat | lowest published toxic dose: 350 mg/kg/7D- intermittent | Gastrointestinal: Other changes | FATOAO 47,87,1984 |
| oral/rat | lowest published toxic dose: 500 mg/kg/5D- intermittent | Gastrointestinal: Other changes Biochemical: Metabolism (intermediary): Lipids including transport | EKFAE9 61,21,1998 |
| oral/rat | lowest published toxic dose: 39.7 mg/kg/3D- intermittent | Blood: Change in clotting factors | EKFAE9 62,38,1999 |
| oral/rat | lowest published toxic dose: 6300 mg/kg/6W- continuous | Liver: Tumors Tumorigenic: Protects against induction of experimental tumors Tumorigenic: Active as anti-cancer agent | CALEDQ 143,173,1999 |
| oral/rat | lowest published toxic dose: 2.625 mg/kg/1W- continuous | Liver: Other changes Blood: Change in clotting factors Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | VCVGK* -,212,1994 |
| oral/rat | lowest published toxic dose: 2000 mg/kg/4D- intermittent | Liver: Multiple effects Kidney, Ureter, and Bladder: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | VCVGK* -,212,1994 |
| oral/rat | lowest published toxic dose: 4200 mg/kg/14D- continuous | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases | BIJOAK 300,117,1994 |
| oral/rat | lowest published toxic dose: 778.4 mg/kg/28D- continuous | Liver: Other changes | FCTOD7 46,2616,2008 |
| oral/rat | lowest published toxic dose: 2458.4 mg/kg/28D- continuous | Liver: Other changes Liver: Changes in liver weight | FCTOD7 46,2616,2008 |
| oral/rat | lowest published toxic dose: 4673.2 mg/kg/28D- continuous | Liver: Other changes Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) | FCTOD7 46,2616,2008 |
| oral/rat | lowest published toxic dose: 8999.2 mg/kg/28D- continuous | Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | FCTOD7 46,2616,2008 |
| oral/rat | lowest published toxic dose: 32446.4 mg/kg/28D- continuous | Liver: Other changes Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FCTOD7 46,2616,2008 |
| oral/rat | lowest published toxic dose: 239400 mg/kg/76W- intermittent | Liver: Other changes Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HPV260 -,-,2001 |
| oral/rat | lowest published toxic dose: 119700 mg/kg/76W- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HPV260 -,-,2001 |
| skin/mouse | lowest published toxic dose: 5 gm/kg/4W- intermittent | Lung, Thorax, or Respiration: Changes in lung weight Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TOLED5 34,99,1986 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 2 mg/m3 (inhal, vapor) | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Limited Evidence | IMEMDT 40,161,1986 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human No Adequate Data | IMEMDT 40,161,1986 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Group 3 | IMSUDL 7,56,1987 |
| TOXICOLOGY REVIEW | IJTOFN 21,19,2002 | |
| TOXICOLOGY REVIEW | ENTOX* -,365,2005 | |
| TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
| TOXICOLOGY REVIEW | MUREAV 659,15,2008 | |
| TOXICOLOGY REVIEW | HUTOX* -,259,1996 | |
| TOXICOLOGY REVIEW | HUTOX* -,577,1996 | |
| TOXICOLOGY REVIEW | MUREAV 705,184,2010 | |
| TOXICOLOGY REVIEW | MUREAV 721,27,2011 |
Standards and Regulations
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 2,6-DI-t-BUTYL-p-CRESOL-air | 10H time-weighted average 10 mg/m3 | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 83383; Number of Industries 210; Total Number of Facilities 27242; Number of Occupations 154; Total Number of Employees Exposed 591238; Total Number of Female Employees Exposed 163774 | |
| National Occupational Hazard Survey 1974 | Hazard Code 83383; Number of Industries 32; Total Number of Facilities 1526; Number of Occupations 39; Total Number of Employees Exposed 28860 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-reciprocal translocation | |
| EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus; Sperm morphology-mouse | |
| EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal | |
| EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; Mouse specific locus | |
| EPA GENETOX PROGRAM 1988, Positive: D melanogaster-whole sex chrom. loss | |
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| EPA TSCA Section 8(d) unpublished health/safety studies | |
| EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9076 | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
| NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat | NCITR* NCI-TR-150,1979 |
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division