Registry of Toxic Effects of Chemical Substances (RTECS)
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m-Cresol, 4,4'-thiobis(6-tert-butyl-
RTECS #
GP3150000CAS #
96-69-5Updated
September 201Molecular Weight
358.58Molecular Formula
C22H30O2SSynonyms
1,1'-Thiobis(2-methyl-4-hydroxy-5-tert-butylbenzene)4,4'-Thiobis
4,4'-Thiobis(2-(1,1-dimethylethyl)-5-methylphenol)
4,4'-Thiobis(2-tert-butyl-5-methylphenol)
4,4'-Thiobis(3-methyl-6-tert-butylphenol)
4,4'-Thiobis(6-tert-butyl-3-methylphenol)
4,4'-Thiobis(6-tert-butyl-m-cresol)
4,4'-Thiobis(6-tert-butyl-m-cresol) (ACGIH,OSHA)
Antage Crystal
Antioxidant AO
Antioxidant TMB 6
AO 4
Bis(3-tert-butyl-4-hydroxy-6-methylphenyl) sulfide
Bis(4-hydroxy-5-tert-butyl-2-methylphenyl) sulfide
Disperse MB-61
Nocrac 300
Nonflex BPS
Phenol, 4,4'-thiobis(2-(1,1-dimethylethyl)-5-methyl- (9CI)
Santonox
Santonox BM
Santonox R
Santowhite crystals
Santox
Sumilizer WX
Sumilizer WX-R
Thioalkofen BM 4
Thioalkofen BMCH
Thioalkofen MBCH
Thioalkophene BM-4
USAF B-15
Yoshinox S
Yoshinox SR
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/mouse | 5508.3 mg/kg (61D male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands | ARTODN 80,225,2006 |
| oral/mouse | 25803 mg/kg (61D male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands | ARTODN 80,225,2006 |
| oral/rat | 11742.5 mg/kg (61D male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands | ARTODN 80,225,2006 |
| oral/rabbit | 26 mg/kg (6-18D pregnant) | Reproductive: Other effects on female Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) | HPV260 -,-,2001 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intraperitoneal/mouse | lethal dose (50 percent kill): 50 mg/kg | NTIS** AD277-689 | |
| oral/rabbit | lethal dose (50 percent kill): 3200 mg/kg | IPSTB3 3,93,1976 | |
| oral/rat | lethal dose (50 percent kill): 4150 mg/kg | Behavioral: Food intake (animal) Gastrointestinal: Gastritis Liver: Other changes | HPV260 -,-,2001 |
| oral/rat | lethal dose (50 percent kill): 2345 mg/kg | IPSTB3 3,93,1976 | |
| skin/rabbit | lethal dose (50 percent kill): >5010 mg/kg | Lung, Thorax, or Respiration: Other changes Liver: Other changes Kidney, Ureter, and Bladder: Other changes | HPV260 -,-,2001 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/mouse | lowest published toxic dose: 1400 mg/kg/14D- intermittent | Liver: Changes in liver weight Endocrine: Changes in spleen weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) | FAATDF 10,691,1988 |
| oral/mouse | lowest published toxic dose: 5915 mg/kg/13W- continuous | Liver: Changes in liver weight Endocrine: Changes in spleen weight | NTPTR* NTP-TR-435,1994 |
| oral/mouse | lowest published toxic dose: 5508.3 mg/kg/61D- intermittent | Related to Chronic Data: Changes in testicular weight | ARTODN 80,225,2006 |
| oral/mouse | lowest published toxic dose: 10980 mg/kg/61D- intermittent | Endocrine: Androgenic | ARTODN 80,225,2006 |
| oral/mouse | lowest published toxic dose: 25803 mg/kg/61D- intermittent | Liver: Changes in liver weight Related to Chronic Data: Changes in prostate weight Related to Chronic Data: Changes in testicular weight | ARTODN 80,225,2006 |
| oral/mouse | lowest published toxic dose: 18239 mg/kg/61D- intermittent | Nutritional and Gross Metabolic: Body temperature decrease Related to Chronic Data: Changes in uterine weight | ARTODN 80,225,2006 |
| oral/mouse | lowest published toxic dose: 2730 mg/kg/2Y- intermittent | Liver: Liver function tests impaired Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | HPV260 -,-,2001 |
| oral/mouse | lowest published toxic dose: 10920 mg/kg/2Y- intermittent | Liver: Liver function tests impaired Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood: Changes in erythrocyte (RBC) count | HPV260 -,-,2001 |
| oral/mouse | lowest published toxic dose: 10920 mg/kg/13W- intermittent | Blood: Changes in erythrocyte (RBC) count | HPV260 -,-,2001 |
| oral/mouse | lowest published toxic dose: 27300 mg/kg/13W- intermittent | Liver: Changes in liver weight Blood: Changes in erythrocyte (RBC) count Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | HPV260 -,-,2001 |
| oral/mouse | lowest published toxic dose: 4500 mg/kg/15D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HPV260 -,-,2001 |
| oral/mouse | lowest published toxic dose: 9000 mg/kg/15D- intermittent | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | HPV260 -,-,2001 |
| oral/rat | lowest published toxic dose: 36500 mg/kg/2Y- intermittent | Liver: Other changes Kidney, Ureter, and Bladder: Other changes Blood: Changes in erythrocyte (RBC) count | HPV260 -,-,2001 |
| oral/rat | lowest published toxic dose: 3750 mg/kg/15D- intermittent | Gastrointestinal: Hypermotility, diarrhea Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HPV260 -,-,2001 |
| oral/rat | lowest published toxic dose: 7500 mg/kg/15D- intermittent | Gastrointestinal: Hypermotility, diarrhea Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | HPV260 -,-,2001 |
| oral/rat | lowest published toxic dose: 4550 mg/kg/13W- intermittent | Liver: Other changes Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Blood: Other changes | HPV260 -,-,2001 |
| oral/rat | lowest published toxic dose: 5475 mg/kg/15D- continuous | Gastrointestinal: Ulceration or bleeding from stomach Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Blood: Changes in leukocyte (WBC) count | NTPTR* NTP-TR-435,1994 |
| oral/rat | lowest published toxic dose: 15015 mg/kg/13W- continuous | Liver: Changes in liver weight Blood: Normocytic anemia Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases | NTPTR* NTP-TR-435,1994 |
| oral/rat | lowest published toxic dose: 11742.5 mg/kg/61D- intermittent | Blood: Changes in spleen Related to Chronic Data: Changes in prostate weight Related to Chronic Data: Changes in testicular weight | ARTODN 80,225,2006 |
| subcutaneous/mouse | lowest published toxic dose: 150 mg/kg/3D- intermittent | Related to Chronic Data: Changes in uterine weight | ARTODN 80,225,2006 |
| subcutaneous/mouse | lowest published toxic dose: 240 mg/kg/4D- intermittent | Related to Chronic Data: Changes in uterine weight | ARTODN 80,225,2006 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 1 mg/m3 (inhal) | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | MUREAV 543,201,2003 | |
| TOXICOLOGY REVIEW | TOPADD 33,517,2005 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 10 mg/m3, JUL2008 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 10 mg/m3, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 10 mg/m3, MAY2011 | |
| Occupational Exposure Limit-FRANCE | VME 10 mg/m3, FEB2006 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 10 mg/m3, NOV2011 | |
| Occupational Exposure Limit-KOREA | time-weighted average 10 mg/m3, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 10 mg/m3;short term exposure limit 20 mg/m3, 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 10 mg/m3, JAN2002 | |
| Occupational Exposure Limit-PERU | time-weighted average 10 mg/m3, JUL2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 10 mg/m3, inhal, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 10 mg/m3, 2003 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 10 mg/m3;short term exposure limit 20 mg/m3, OCT2007 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 15 mg/m3, total dust | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 5 mg/m3, respirable fraction | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 15 mg/m3, total dust | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 5 mg/m3, respirable fraction | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 15 mg/m3, total dust | CFRGBR 29,1915.1000,1993 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 5 mg/m3, respirable fraction | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 4,4'-THIOBIS(6-t-BUTYL-m-CRESOL), dust-air | time-weighted average 10 mg/m3 | NIOSH* DHHS #92-100,1992 |
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 4,4'-THIOBIS(6-t-BUTYL-m-CRESOL)-air | 10H time-weighted average 5 mg/m3 | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 84755; Number of Industries 10; Total Number of Facilities 1286; Number of Occupations 11; Total Number of Employees Exposed 12349; Total Number of Female Employees Exposed 2177 | |
| National Occupational Hazard Survey 1974 | Hazard Code 84755; Number of Industries 51; Total Number of Facilities 4402; Number of Occupations 47; Total Number of Employees Exposed 36695 |
Status in Federal Agencies
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division