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Registry of Toxic Effects of Chemical Substances (RTECS)

Cyanamide

RTECS #

GS5950000

CAS #

420-04-2; 65931-45-5

Updated

September 201

Molecular Weight

42.05

Molecular Formula

CH2N2

Synonyms

Alzogur
Amidocyanogen
Carbamonitrile
Carbimide
Carbodiimide
Cyanamide (ACGIH)
Cyanoamine
Cyanogen nitride
Cyanogenamide
Hydrogen cyanamide
N-Cyanoamine
TsAKS
USAF EK-1995

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 2450 mg/kg (70D male/2W pre-2W pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Other measures of fertility		PHTOEH 61,20,1987
oral/rat 1750 mg/kg (70D male)Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)		PHTOEH 61,20,1987
oral/rat 2600 mg/kg (70D male/2W pre-3W pregnant)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Delayed effects		PHTOEH 61,20,1987
oral/rat 208 mg/kg (70D male/2W pre-3W pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)		PHTOEH 61,20,1987

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lowest published lethal concentration: 86 mg/m3/4H85GMAT -,40,1982
intraperitoneal/mouse lethal dose (50 percent kill): 200 mg/kgNTIS** AD277-689
intraperitoneal/rat lowest published lethal dose: 200 mg/kgEye: Miosis (pupilliary constriction)

Behavioral: Coma

Gastrointestinal: Changes in structure or function of salivary glands		PSEBAA 54,254,1943
intraperitoneal/rat lowest published toxic dose: 60 mg/kgBrain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport		EKFAE9 59,38,1996
intraperitoneal/rat lowest published toxic dose: 25 gm/kgTaste: Change in functionPSCHDL 167,130,2003
intraperitoneal/rat lowest published toxic dose: 50 mg/kgNutritional and Gross Metabolic: Body temperature decreasePSCHDL 189,459,2007
intravenous/rat lethal dose (50 percent kill): 56 mg/kgENTOX* -,695,2005
oral/cat lethal dose (50 percent kill): 100 mg/kg85GMAT -,40,1982
oral/mouse lethal dose (50 percent kill): 388 mg/kg85GMAT -,40,1982
oral/rabbit lethal dose (50 percent kill): 150 mg/kg85GMAT -,40,1982
oral/rat lethal dose (50 percent kill): 125 mg/kgENTOX* -,695,2005
skin/rabbit lethal dose (50 percent kill): 590 mg/kgENTOX* -,695,2005
skin/rat lethal dose (50 percent kill): 84 mg/kgENTOX* -,695,2005
unreported route/rat lethal dose (50 percent kill): 280 mg/kg34ZIAG -,190,1969

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
unreported route/human lowest published toxic dose: 312 mg/kg/182D- intermittentBlood: Aplastic anemiaEJCPAS 61,467,2005
unreported route/woman lowest published toxic dose: 61 mg/kg/61D- intermittentBlood: Aplastic anemiaSANGR* 35,412,1990
unreported route/woman lowest published toxic dose: 20 mg/kg/20D- intermittentBlood: Aplastic anemiaEJHAEC 48,179,1992

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 2 mg/m3DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWENTOX* -,695,2005

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESActive registrationRBREV* -,373,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 10 ppm (11 mg/m3) (skin)DTLVS* 3,130,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 2 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.58 ppm (1 mg/m3), inhal, skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.58 ppm (1 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.58 ppm (1 mg/m3), skin, MAY2011
Occupational Exposure Limit-ECtime-weighted average 1 mg/m3 (0.58 ppm), skin, FEB2006
Occupational Exposure Limit-FINLANDtime-weighted average 1 mg/m3, skin, NOV2011
Occupational Exposure Limit-FRANCEVME 2 mg/m3, FEB2006
Occupational Exposure Limit-GERMANYMAK 0.2 ppm (0.35 mg/m3), inhal, vapor, 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 2 mg/m3 (resp), short term exposure limit 8 mg/m3 (resp), SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 0.58 ppm (1 mg/m3), skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 2 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 2 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 2 mg/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 2 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 2 mg/m3, JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.5 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 2 mg/m3;short term exposure limit 4 mg/m3, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.58 ppm (1 mg/m3), KZG-week 1.16 ppm (2 mg/m3), inhal, skin, sen, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 2 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.58 ppm (1 mg/m3), skin, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CYANAMIDE-air10H time-weighted average 2 mg/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 20930; Number of Industries 2; Total Number of Facilities 19; Number of Occupations 2; Total Number of Employees Exposed 2564; Total Number of Female Employees Exposed 272
National Occupational Hazard Survey 1974Hazard Code 20930; Number of Industries 2; Total Number of Facilities 76; Number of Occupations 2; Total Number of Employees Exposed 962

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

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