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Registry of Toxic Effects of Chemical Substances (RTECS)

Cyanogen chloride

RTECS #

GT2275000

CAS #

506-77-4

Updated

September 201

Molecular Weight

61.47

Molecular Formula

CClN

Synonyms

Chlorcyan
Chlorine cyanide
Chlorocyan
Chlorocyanide
Chlorocyanogen
Chlorure de cyanogene (French)
Cyanogen chloride (ACGIH)
RCRA waste number P033

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 10 mg/m3Eye: Lacrimation

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion		WHOTAC -,31,1970
inhalation/human lowest published toxic concentration: 2 mg/m3Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi		TOVEFN (2),39,2001
inhalation/human lowest published toxic concentration: 60 mg/m3Eye: Lacrimation

Eye: Change in extra- ocular muscles		TOVEFN (2),39,2001
inhalation/human Lowest published lethal concentration: 400 mg/m3/10MBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)		TOVEFN (2),39,2001
inhalation/man lowest published toxic concentration: 2 gm/m3Skin: After topical application: Primary irritationNTIS** PB158-508
inhalation/rat lethal concentration (50 percent kill): 600 mg/m3/4HTOVEFN (2),39,2001
oral/cat lethal dose (50 percent kill): 6 mg/kgENTOX* -,701,2005
subcutaneous/Dog lowest published lethal dose: 5 mg/kgHBAMAK 4,1341,1935
subcutaneous/pigeon lowest published lethal dose: 8700 µg/kgHBAMAK 4,1341,1935
subcutaneous/rabbit lowest published lethal dose: 20 mg/kgHBAMAK 4,1341,1935
unreported route/Dog lethal dose (50 percent kill): 3300 µg/kgNTIS** PB158-508
unreported route/domestic animal lethal dose (50 percent kill): 2970 µg/kgNTIS** PB158-508
unreported route/rabbit lethal dose (50 percent kill): 3150 µg/kgNTIS** PB158-508

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-ceiling concentration 0.3 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWMUREAV 539,77,2003
TOXICOLOGY REVIEWCPEMM* 3,239,2002
TOXICOLOGY REVIEWENTOX* -,701,2005
TOXICOLOGY REVIEWCCACL* 21,691,2005

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAceiling concentration 0.3 ppm (0.75 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.3 ppm (0.6 mg/m3);KZW 0.3 ppm (0.6 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.3 ppm (0.76 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.1 ppm (0.3 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDshort term exposure limit 0.1 ppm (0.26 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVLE 0.3 ppm (0.6 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 2 mg(CN)/m3, inhal, 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 5 mg(CN)/m3, short term exposure limit 20 mg(CN)/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 0.1 ppm (0.3 mg/m3), NOV2011
Occupational Exposure Limit-KOREAceiling concentration 0.3 ppm (0.6 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 5 mg(CN)/m3, 2004
Occupational Exposure Limit-NEW ZEALANDceiling concentration 0.3 ppm (0.75 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.25 ppm (0.6 mg/m3), JAN1999
Occupational Exposure Limit-PERUshort term exposure limit 0.3 ppm (0.75 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.2 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.1 ppm (0.3 mg/m3);short term exposure limit 0.3 ppm (0.8 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDceiling concentration 2 mg(CN)/m3, inhal, skin, JAN2011
Occupational Exposure Limit-SWITZERLANDMAK-week 0.3 ppm (0.8 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-C 0.6 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMshort term exposure limit 0.3 ppm (0.77 mg/m3), OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CYANOGEN CHLORIDE-airceiling concentration 0.3 ppmNIOSH* DHHS #95-121,1995
National Occupational Exposure Survey 1983Hazard Code 84337; Number of Industries 1; Total Number of Facilities 4; Number of Occupations 16; Total Number of Employees Exposed 1391
National Occupational Hazard Survey 1974Hazard Code 84337; Number of Industries 1; Total Number of Facilities 34; Number of Occupations 1; Total Number of Employees Exposed 134

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/98/101207/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9033
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; selected, October 2000
On EPA IRIS database

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