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Registry of Toxic Effects of Chemical Substances (RTECS)

Cyclohexane

RTECS #

GU6300000

CAS #

110-82-7

Updated

September 201

Molecular Weight

84.18

Molecular Formula

C6H12

Synonyms

Benzene, hexahydro-
Cicloesano (Italian)
Cyclohexaan (Dutch)
Cyclohexan (German)
Cyclohexane (ACGIH:OSHA)
Cykloheksan (Polish)
Hexahydrobenzene
Hexamethylene
Hexanaphthene
RCRA waste number U056

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 1548 mg/2D- intermittentJIHTAB 25,199,1943

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA adduct/Escherichia coli10 µmol/LMUREAV 89,95,1981

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 2000 ppm (multigeneration)Reproductive: Other effects on femaleHPV250 -,-,2008
inhalation/rat 7000 ppm (multigeneration)Reproductive: Other effects on female

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)		HPV250 -,-,2008
inhalation/rat 6000 ppm (7-16D pregnant)Reproductive: Other effects on femaleHPV250 -,-,2008

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/cat lowest published toxic concentration: 62500 mg/m3/15MBehavioral: Convulsions or effect on seizure threshold

Vascular: BP lowering not characterized in autonomic section		VCVGH* -,82,1990
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): 70 gm/m3GTPZAB 32(10),25,1988
inhalation/mouse lethal concentration (50 percent kill): 70000 mg/m3/2HVCVGH* -,82,1990
inhalation/mouse Lowest published lethal concentration: 70 gm/m3/2H85GMAT -,41,1982
inhalation/rabbit Lowest published lethal concentration: 89600 mg/m3/1HBehavioral: General anesthetic

Behavioral: Tremor

Behavioral: Muscle contraction or spasticity		JIHTAB 25,323,1943
inhalation/rabbit Lowest published lethal concentration: 89500 mg/m3/1HBehavioral: General anestheticVCVGH* -,82,1990
inhalation/rat lethal concentration (50 percent kill): >9500 ppm/4HBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression		HPV250 -,-,2008
oral/mouse lethal dose (50 percent kill): 813 mg/kgENTOX* -,705,2005
oral/rabbit lethal dose (50 percent kill): 5.5 mg/kgENTOX* -,705,2005
oral/rabbit lowest published lethal dose: 5500 mg/kgGastrointestinal: Hypermotility, diarrheaJIHTAB 25,199,1943
oral/rat lethal dose (50 percent kill): >5000 mg/kgHPV250 -,-,2008
oral/rat lethal dose (50 percent kill): 6240 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Hypermotility, diarrhea		HPV250 -,-,2008
skin/rabbit lethal dose (50 percent kill): >2000 mg/kgHPV250 -,-,2008
skin/rabbit Lethal dose: >180 gm/kgJIHTAB 25,199,1943

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 2000 ppm/90D- intermittentBehavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)		TOXID9 42,255,1998
inhalation/mouse lowest published toxic concentration: 2000 ppm/13W- intermittentBehavioral: Somnolence (general depressed activity)HPV250 -,-,2008
inhalation/mouse lowest published toxic concentration: 7000 ppm/13W- intermittentBehavioral: Somnolence (general depressed activity)

Liver: Changes in liver weight		HPV250 -,-,2008
inhalation/rabbit lowest published toxic concentration: 7444 ppm/6H/2W- intermittentAutonomic Nervous System: Other (direct) parasympathomimetic

Gastrointestinal: Hypermotility, diarrhea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		JIHTAB 25,323,1943
inhalation/rabbit lowest published toxic concentration: 9220 ppm/6H/5W- intermittentAutonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Tremor

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		JIHTAB 25,323,1943
inhalation/rat lowest published toxic concentration: 6000 ppm/9D- intermittentBehavioral: Somnolence (general depressed activity)

Liver: Other changes		HPV250 -,-,2008
inhalation/rat lowest published toxic concentration: 9000 ppm/9D- intermittentBehavioral: Somnolence (general depressed activity)

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		HPV250 -,-,2008
inhalation/rat lowest published toxic concentration: 500 ppm/13W- intermittentBehavioral: Somnolence (general depressed activity)HPV250 -,-,2008
inhalation/rat lowest published toxic concentration: 2000 ppm/13W- intermittentBehavioral: Somnolence (general depressed activity)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases		HPV250 -,-,2008
inhalation/rat lowest published toxic concentration: 7000 ppm/13W- intermittentBehavioral: Somnolence (general depressed activity)

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases		HPV250 -,-,2008
inhalation/rat lowest published toxic concentration: 300 ppm/6H/2W- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases		TOLED5 7,17,1980
intraperitoneal/rat lowest published toxic dose: 15 gm/kg/2W- intermittentKidney, Ureter, and Bladder: Other changes in urine compositionTOLED5 45,271,1989

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 100 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWENTOX* -,705,2005
TOXICOLOGY REVIEWNCLNA* 16,503,1998
TOXICOLOGY REVIEWNEUCL* 18,215,2000

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 300 ppm (1050 mg/m3)DTLVS* 3,65,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 100 ppm (350 mg/m3), short term exposure limit 300 ppm (1050 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 200 ppm (700 mg/m3);KZW 800 ppm (2800 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 200 ppm (700 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 50 ppm (172 mg/m3), MAY2011
Occupational Exposure Limit-ECtime-weighted average 700 mg/m3 (200 ppm), FEB2006
Occupational Exposure Limit-FINLANDtime-weighted average 100 ppm (350 mg/m3), short term exposure limit 250 ppm (875 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 300 ppm (1050 mg/m3), VLE 375 ppm (1300 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 200 ppm (700 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 700 mg/m3, short term exposure limit 2800 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 50 ppm (175 mg/m3), NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 150 ppm (520 mg/m3), MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 300 ppm (1050 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 300 ppm (1050 mg/m3);short term exposure limit 375 ppm (1300 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 100 ppm (350 mg/m3); short term exposure limit 300 ppm (1500 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 150 ppm (525 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 100 ppm (344 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 300 mg/m3, MAC(short term exposure limit) 1000 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 80 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 300 ppm (1000 mg/m3);short term exposure limit 370 ppm (1300 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 200 ppm (700 mg/m3), KZG-week 800 ppm (2800 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 875 mg/m3, 2003
Occupational Exposure Limit-TURKEYtime-weighted average 300 ppm (1050 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 100 ppm (350 mg/m3);short term exposure limit 300 ppm (1050 mg/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 300 ppm (1050 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 300 ppm (1050 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 300 ppm (1050 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 300 ppm (1050 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CYCLOHEXANE-air10H time-weighted average 300 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 21190; Number of Industries 37; Total Number of Facilities 2260; Number of Occupations 54; Total Number of Employees Exposed 55077; Total Number of Female Employees Exposed 14873
National Occupational Hazard Survey 1974Hazard Code 21190; Number of Industries 117; Total Number of Facilities 14841; Number of Occupations 74; Total Number of Employees Exposed 125761

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE; Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Hydrocarbons, BP 36-126 degree C, 1500
On EPA IRIS database

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