Registry of Toxic Effects of Chemical Substances (RTECS)
Cyclohexane, methyl-
RTECS #
GV6125000CAS #
108-87-2Updated
September 201Molecular Weight
98.21Molecular Formula
C7H14Synonyms
CyclohexylmethaneHexahydrotoluene
Methylcyclohexane
Methylcyclohexane (ACGIH:OSHA)
Metylocykloheksan (Polish)
Sextone B
Toluene hexahydride
Toluene, hexahydro-
Skin and Eye Irritation and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
eye /rabbit | 100 µL/24H | mild | NTIS** OTS0556748 |
skin /rabbit | 500 µL/24H | mild | NTIS** OTS0556749 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/mouse | lethal concentration (16 percent kill): 35000 mg/m3/2H | VCVGH* -,84,1990 | |
inhalation/mouse | lethal concentration (50 percent kill): 36900 mg/m3/2H | VCVGH* -,84,1990 | |
inhalation/mouse | lethal concentration (84 percent kill): 47000 mg/m3/2H | VCVGH* -,84,1990 | |
inhalation/rabbit | Lowest published lethal concentration: 60000 mg/m3/70M | Eye: Conjunctiva irritation Behavioral: General anesthetic Behavioral: Convulsions or effect on seizure threshold | VCVGH* -,84,1990 |
inhalation/rabbit | lethal concentration (50 percent kill): 15227 ppm/1H | Behavioral: General anesthetic Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Changes in structure or function of salivary glands | JIHTAB 25,323,1943 |
inhalation/rat | Lowest published lethal concentration: 82 gm/m3/1H | Behavioral: General anesthetic Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia | NTIS** OTS0556685 |
oral/mouse | lethal dose (16 percent kill): 1.28 gm/kg | VCVGH* -,85,1990 | |
oral/mouse | lethal dose (50 percent kill): 1.2 gm/kg | VCVGH* -,85,1990 | |
oral/mouse | lethal dose (84 percent kill): 3.4 gm/kg | VCVGH* -,85,1990 | |
oral/rabbit | lowest published lethal dose: 4 gm/kg | Gastrointestinal: Hypermotility, diarrhea | JIHTAB 25,199,1943 |
oral/rat | lethal dose (50 percent kill): >3200 mg/kg | NTIS** OTS0556685 | |
skin/rabbit | Lethal dose: >86700 mg/kg | JIHTAB 25,199,1943 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/rabbit | lowest published toxic concentration: 10054 ppm/6H/2W- intermittent | Eye: Conjunctiva irritation Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | JIHTAB 25,323,1943 |
inhalation/rat | lowest published toxic concentration: 11 gm/m3/6H/5D- intermittent | Behavioral: General anesthetic | NTIS** OTS0556685 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 400 ppm | DTLVS* TLV/BEI,2013 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 500 ppm (2000 mg/m3) | DTLVS* 3,162,1971 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
Occupational Exposure Limit-AUSTRALIA | time-weighted average 400 ppm (1610 mg/m3), JUL2008 | |
Occupational Exposure Limit-AUSTRIA | MAK-TMW 400 ppm (1600 mg/m3);KZW 1600 ppm (6400 mg/m3), 2007 | |
Occupational Exposure Limit-BELGIUM | time-weighted average 400 ppm (1633 mg/m3), MAR2002 | |
Occupational Exposure Limit-DENMARK | time-weighted average 200 ppm (805 mg/m3), MAY2011 | |
Occupational Exposure Limit-FINLAND | time-weighted average 400 ppm (1600 mg/m3), short term exposure limit 500 ppm (2000 mg/m3), NOV2011 | |
Occupational Exposure Limit-FRANCE | VME 400 ppm (1600 mg/m3), FEB2006 | |
Occupational Exposure Limit-GERMANY | MAK 200 ppm (810 mg/m3), 2011 | |
Occupational Exposure Limit-ICELAND | time-weighted average 200 ppm (805 mg/m3), NOV2011 | |
Occupational Exposure Limit-JAPAN | Occupational Exposure Limit 400 ppm (1600 mg/m3), MAY2012 | |
Occupational Exposure Limit-KOREA | time-weighted average 400 ppm (1600 mg/m3), 2006 | |
Occupational Exposure Limit-MEXICO | time-weighted average 400 ppm (1600 mg/m3);short term exposure limit 500 ppm (2000 mg/m3), 2004 | |
Occupational Exposure Limit-NEW ZEALAND | time-weighted average 400 ppm (1610 mg/m3), JAN2002 | |
Occupational Exposure Limit-PERU | time-weighted average 400 ppm (1606 mg/m3), JUL2005 | |
Occupational Exposure Limit-POLAND | MAC(time-weighted average) 500 mg/m3, MAC(short term exposure limit) 2000 mg/m3, JAN1999 | |
Occupational Exposure Limit-RUSSIA | short term exposure limit 50 mg/m3, JUN2003 | |
Occupational Exposure Limit-SWITZERLAND | MAK-week 400 ppm (1600 mg/m3), KZG-week 800 ppm (3200 mg/m3), JAN2011 | |
Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 1600 mg/m3, 2003 | |
Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 500 ppm (2000 mg/m3), JAN1993 | |
Occupational Exposure Limit-TURKEY | time-weighted average 500 ppm (2000 mg/m3), JAN1993 | |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 500 ppm (2000 mg/m3) | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 500 ppm (2000 mg/m3) | CFRGBR 41,50-204.50,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 500 ppm (2000 mg/m3) | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 500 ppm (2000 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYLCYCLOHEXANE-air | 10H time-weighted average 400 ppm | NIOSH* DHHS #92-100,1992 |
National Occupational Exposure Survey 1983 | Hazard Code 47030; Number of Industries 12; Total Number of Facilities 1175; Number of Occupations 11; Total Number of Employees Exposed 10076; Total Number of Female Employees Exposed 14 | |
National Occupational Hazard Survey 1974 | Hazard Code 47030; Number of Industries 11; Total Number of Facilities 1733; Number of Occupations 9; Total Number of Employees Exposed 6292 |
Status in Federal Agencies
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division