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Registry of Toxic Effects of Chemical Substances (RTECS)

Cyclohexylamine

RTECS #

GX0700000

CAS #

108-91-8

Updated

September 201

Molecular Weight

99.20

Molecular Formula

C6H13N

Synonyms

Aminocyclohexane
Aminohexahydrobenzene
Aniline, hexahydro-
Benzenamine, hexahydro-
CHA
Cyclohexanamine
Cyclohexylamine (ACGIH)
Hexahydroaniline
Hexahydrobenzenamine

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 50 µg/24H severe85JCAE -,454,1986
eye /rabbit 100 µL/5M severeNTIS** OTS0540890
skin /human 125 mg/48H severeAMIHBC 5,311,1952
skin /rabbit 2 mg/24H severe85JCAE -,454,1986
skin /rabbit 500 µL severeNTIS** OTS0540890

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisleukocyte/human10 µmol/L/5HMUREAV 39,1,1976
Cytogenetic Analysisintraperitoneal/rat5 mg/kg/5D-continuousSCIEAS 165,1139,1969
Cytogenetic Analysisfibroblast/hamster10 mg/LMUREAV 39,1,1976
Cytogenetic Analysisunreported route/domestic animal50 mg/kgMUREAV 26,407,1974
Cytogenetic Analysiskidney/mammal (species unspecified)50 mg/L/8H-continuousFCTXAV 8,617,1970
DNA inhibitionHeLa cell/human100 µg/LINHEAO 9,188,1971
Dominant Lethal Testintraperitoneal/mouse500 mg/kg/5D- intermittentMUREAV 14,126,1972
host-mediated assayleukocyte/hamster450 mg/kg/3D-continuousMUREAV 31,5,1975
morphological transformembryo/hamster60 mg/LAETODY 1,241,1980
specific locus testintraperitoneal/mouse200 mg/kgPCBRD2 109,339,1982

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 300 mg/kg (1D male)Reproductive: Effects on fertility: Other measures of fertilityFCTXAV 10,29,1972
intraperitoneal/rat 100 mg/kg (1D male)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)FCTXAV 10,29,1972
intraperitoneal/mouse 61 mg/kg (11D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TJADAB 4,141,1971
intraperitoneal/mouse 77 mg/kg (11D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)TJADAB 4,141,1971
intraperitoneal/mouse 200 mg/kg (10D pregnant)Reproductive: Effects on fertility: Other measures of fertilityPCBRD2 109,339,1982
oral/mouse 600 mg/kg (6-11D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death		SEIJBO 11,51,1971
oral/mouse 120 mg/kg (6-11D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)SEIJBO 11,51,1971
oral/Dog 14 gm/kg (8W male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)FCTXAV 19,291,1981
oral/Dog 15750 mg/kg (9W male)Reproductive: Paternal effects: Testes, epididymis, sperm ductFCTXAV 19,291,1981
oral/rat 5600 mg/kg (4W male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)FCTXAV 19,291,1981
parenteral/mouse 250 mg/kg (5D male)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)AMESES 1,33,1970
unreported route/rat 5 mg/kg (1D male)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)AMESES 1,25,1970

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig Lowest published lethal concentration: 1200 ppm/7HLung, Thorax, or Respiration: Other changesIMSUAI 19,317,1950
inhalation/mouse lethal concentration (50 percent kill): 1070 mg/m3Behavioral: Excitement

Behavioral: Muscle contraction or spasticity		GTPZAB 7(11),51,1963
inhalation/rabbit Lowest published lethal concentration: 150 ppm/7HIMSUAI 19,317,1950
inhalation/rat lethal concentration (50 percent kill): 7500 mg/m3Behavioral: Excitement

Behavioral: Muscle contraction or spasticity		GTPZAB 7(11),51,1963
intraperitoneal/mammal (species unspecified) lethal dose (50 percent kill): 200 mg/kgBrain and Coverings: Other degenerative changes

Vascular: Shock

Liver: Other changes		AMIHBC 5,311,1952
intraperitoneal/mouse lethal dose (50 percent kill): 129 mg/kgPCJOAU 22,469,1988
intraperitoneal/rat lethal dose (50 percent kill): 300 mg/kgEye: Mydriasis (pupilliary dilation)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea		NYKZAU 65(1),53S,1969
intravenous/Dog lethal dose (50 percent kill): 200 mg/kgBehavioral: Convulsions or effect on seizure thresholdNYKZAU 65(1),53S,1969
intravenous/mouse lethal dose (50 percent kill): 200 mg/kgIPSTB3 3,93,1976
oral/mouse lethal dose (50 percent kill): 224 mg/kg85GMAT -,41,1982
oral/rat lethal dose (50 percent kill): 11 mg/kgBehavioral: Food intake (animal)

Lung, Thorax, or Respiration: Pulmonary emboli

Gastrointestinal: Other changes		NTIS** OTS0534836
parenteral/rabbit lowest published lethal dose: 500 mg/kgBehavioral: Convulsions or effect on seizure thresholdIECHAD 29,1247,1937
skin/rabbit lethal dose (50 percent kill): 320 µL/kgAIHAAP 30,470,1969
subcutaneous/mouse lethal dose (50 percent kill): 1150 mg/kgVOONAW 4,659,1958
unreported route/mouse lethal dose (50 percent kill): 770 mg/kgTXAPA9 14,654,1969

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 700 mg/m3/2H/9W- intermittentCardiac: Changes in heart weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		GTPZAB 7(11),51,1963
inhalation/rat lowest published toxic concentration: 100 mg/m3/4H/22W- intermittentKidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in cell count (unspecified)

Nutritional and Gross Metabolic: Other changes		GTPZAB 7(11),51,1963
oral/rat lowest published toxic dose: 1200 mg/kg/3D- continuousBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		EXMPA6 52,155,1990
oral/rat lowest published toxic dose: 2800 mg/kg/1W- continuousRelated to Chronic Data: Changes in testicular weightEXMPA6 52,155,1990
oral/rat lowest published toxic dose: 8400 mg/kg/3W- continuousReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct		EXMPA6 52,155,1990
oral/rat lowest published toxic dose: 35700 mg/kg/1Y- continuousLiver: Other changes

Kidney, Ureter, and Bladder: Other changes		VOONAW 4,659,1958

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 10 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMSUDL 7,178,1987
International Agency for Research on Cancer (IARC)Cancer Review:Animal NO EVIDENCEIMEMDT 22,55,1980
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMSUDL 22,55,1980
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,178,1987
TOXICOLOGY REVIEWMUREAV 39,1,1976
TOXICOLOGY REVIEWNBREV* 17,313,1993

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 10 ppm (41 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 10 ppm (40 mg/m3);KZW 10 ppm (40 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 10 ppm (42 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 10 ppm (40 mg/m3), skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 1 ppm (4.1 mg/m3), short term exposure limit 10 ppm (41 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 10 ppm (40 mg/m3), Skin, FEB2006
Occupational Exposure Limit-GERMANYMAK 2 ppm (8.2 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 40 mg/m3, short term exposure limit 40 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 10 ppm (40 mg/m3), skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 10 ppm (40 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 10 ppm (40 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 10 ppm (41 mg/m3), JAN2002
Occupational Exposure Limit-PERUtime-weighted average 10 ppm (41 mg/m3), JUL2005
Occupational Exposure Limit-POLANDtime-weighted average 40 mg/m3, short term exposure limit 80 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 5 ppm (20 mg/m3);short term exposure limit 10 ppm (40 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 2 ppm (8.2 mg/m3), KZG-week 4 ppm (16.4 mg/m3), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 5 mg/m3, Skin, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 10 ppm (41 mg/m3), OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CYCLOHEXYLAMINE-air10H time-weighted average 10 ppmNIOSH* DHHS #95-121,1995
National Occupational Exposure Survey 1983Hazard Code 84526; Number of Industries 83; Total Number of Facilities 4729; Number of Occupations 47; Total Number of Employees Exposed 64346; Total Number of Female Employees Exposed 2914
National Occupational Hazard Survey 1974Hazard Code 84526; Number of Industries 63; Total Number of Facilities 3468; Number of Occupations 25; Total Number of Employees Exposed 9450

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-whole sex chrom. loss
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
EPA GENETOX PROGRAM 1988, Inconclusive: Rodent dominant lethal; Host-mediated assay
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: D melanogaster-reciprocal translocation
EPA GENETOX PROGRAM 1988, Negative: In vitro cytogenetics-human lymphocyte
EPA GENETOX PROGRAM 1988, Negative: In vivo cytogenetics-nonhuman bone marrow
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro cytogenetics-nonhuman
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE; Cytogenetics-male germ cell
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database

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