Registry of Toxic Effects of Chemical Substances (RTECS)
1,3-Cyclopentadiene, 1,2,3,4,5,5-hexachloro-
RTECS #
GY1225000CAS #
77-47-4Updated
September 201Molecular Weight
272.75Molecular Formula
C5Cl6Synonyms
1,2,3,4,5,5-Hexachloro-1,3-cyclopentadieneC-56
Graphlox
Hexachlorcyklopentadien (Czech)
Hexachloro-1,3-cyclopentadiene
Hexachlorocyclopentadiene
Hexachlorocyclopentadiene (ACGIH)
HRS 1655
NCI-C55607
Perchlorocyclopentadiene
RCRA waste number U130
Skin and Eye Irritation and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
eye /rabbit | 20 mg/24H | moderate | 85JCAE -,149,1986 |
eye /rabbit | 100 mg/5M | severe | VELPB* #50101-2,1976 |
skin /guinea pig | 20 mg | mild | AMIHAB 11,459,1955 |
skin /monkey | 10 mg | severe | AMIHAB 11,459,1955 |
skin /rabbit | 500 mg/4H | severe | VELPB* #50101-2,1976 |
skin /rabbit | 500 µL/24H | severe | NTIS** OTS0537036 |
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
Cytogenetic Analysis | other cell types/hamster | 27.5 µmol/L | MUREAV 608,28,2006 |
Reproductive Effects Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/rabbit | 975 mg/kg (6-18D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system | TXAPA9 53,497,1980 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/cat | Lowest published lethal concentration: 84 mg/m3/7H | VCVGH* -,551,1990 | |
inhalation/Dog | Lowest published lethal concentration: 840 mg/m3/30M | VCVGH* -,551,1990 | |
inhalation/guinea pig | Lowest published lethal concentration: 139 mg/m3/3H | VCVGH* -,551,1990 | |
inhalation/guinea pig | Lowest published lethal concentration: 3200 ppb/7H | AMIHAB 11,459,1955 | |
inhalation/mouse | Lowest published lethal concentration: 139 mg/m3/3H | VCVGH* -,551,1990 | |
inhalation/mouse | Lowest published lethal concentration: 1500 ppb/7H | TXAPA9 53,497,1980 | |
inhalation/rabbit | Lowest published lethal concentration: 1500 ppb/7H | TXAPA9 53,497,1980 | |
inhalation/rabbit | Lowest published lethal concentration: 139 mg/m3/3H | VCVGH* -,551,1990 | |
inhalation/rat | lethal concentration (50 percent kill): 23 mg/m3/2H | VCVGH* -,551,1990 | |
inhalation/rat | Lowest published lethal concentration: 139 mg/m3/3H | VCVGH* -,551,1990 | |
inhalation/rat | lethal concentration (50 percent kill): 1600 ppb/4H | Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Other changes | JTEHD6 9,743,1982 |
oral/mouse | lethal dose (50 percent kill): 505 mg/kg | JAFCAU 23,967,1975 | |
oral/rabbit | lowest published lethal dose: 420 mg/kg | PCOC** -,586,1966 | |
oral/rabbit | lethal dose (50 percent kill): 620 mg/kg | Brain and Coverings: Other degenerative changes Liver: Other changes Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) | ENTOX* -,517,2005 |
oral/rat | lethal dose (50 percent kill): 420 mg/kg | Lung, Thorax, or Respiration: Respiratory depression Gastrointestinal: Hypermotility, diarrhea | ENTOX* -,517,2005 |
oral/rat | lethal dose (50 percent kill): 200 mg/kg | VCVGH* -,552,1990 | |
skin/rabbit | lowest published lethal dose: 300 mg/kg | VCVGH* -,552,1990 | |
skin/rabbit | lethal dose (50 percent kill): 430 mg/kg | 34ZIAG -,308,1969 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/guinea pig | lowest published toxic concentration: 340 ppb/7H/6W- intermittent | Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Nutritional and Gross Metabolic: Weight loss or decreased weight gain | AMIHAB 11,459,1955 |
inhalation/mouse | lowest published toxic concentration: 150 ppb/6H/13W- intermittent | Lung, Thorax, or Respiration: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TOXID9 6,57,1986 |
inhalation/mouse | lowest published toxic concentration: 340 ppb/7H/6W- intermittent | Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | AMIHAB 11,459,1955 |
inhalation/rabbit | lowest published toxic concentration: 340 ppb/7H/6W- intermittent | Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | AMIHAB 11,459,1955 |
inhalation/rat | lowest published toxic concentration: 100 ppb/6H/30W- intermittent | Endocrine: Changes in spleen weight Blood: Pigmented or nucleated red blood cells Blood: Changes in erythrocyte (RBC) count | NTIS** OTS0539137 |
inhalation/rat | lowest published toxic concentration: 500 ppb/6H/2W- intermittent | Lung, Thorax, or Respiration: Changes in lung weight Blood: Pigmented or nucleated red blood cells Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JTEHD6 9,743,1982 |
inhalation/rat | lowest published toxic concentration: 400 ppb/6H/13W- intermittent | Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Changes in lung weight | NTPTR* NTP-TR-437,1994 |
oral/mouse | lowest published toxic dose: 2470 mg/kg/13W- intermittent | Gastrointestinal: Other changes Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, and Bladder: Changes in bladder weight | JJATDK 4,75,1984 |
oral/rat | lowest published toxic dose: 2470 mg/kg/13W- intermittent | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JJATDK 4,75,1984 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.01 ppm | DTLVS* TLV/BEI,2013 |
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
TOXICOLOGY REVIEW | MUREAV 543,201,2003 | |
TOXICOLOGY REVIEW | ENTOX* -,517,2005 | |
TOXICOLOGY REVIEW | MUREAV 584,1,2005 |
Standards and Regulations
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO HEXACHLOROCYCLOPENTADIENE-air | 10H time-weighted average 0.01 ppm | NIOSH* DHHS #92-100,1992 |
National Occupational Hazard Survey 1974 | Hazard Code T0175; Number of Industries 2; Total Number of Facilities 61; Number of Occupations 14; Total Number of Employees Exposed 1427 |
Status in Federal Agencies
Organization | Reference |
---|---|
ATSDR TOXICOLOGY PROFILE (NTIS** PB/99/166670) | |
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE | FEREAC 47,26992,82 |
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
EPA TSCA Section 8(d) unpublished health/safety studies | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
NCI Carcinogenesis Studies (inhal);no evidence:mouse,rat | |
NIOSH Analytical Method, 1994: Hexachloro-1,3-cyclopentadiene, 2518 | |
NTP Carcinogenesis studies (inhalation);no evidence:rat NTPTR* NTP-TR-437,1994 | |
On EPA IRIS database |
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division