Registry of Toxic Effects of Chemical Substances (RTECS)

1,4:5,8-Dimethanonaphthalene, 1,2,3,4,10,10-hexachloro-1,4,4a,5,8,8a-hexahydro-, endo,exo-

RTECS #

IO2100000

CAS #

309-00-2; 34487-55-3

Updated

September 201

Molecular Weight

364.90

Molecular Formula

C₁₂H₈Cl₆

Synonyms

1,2,3,4,10,10-Hexachloro-1,4,4a,5,8,8a-hexahydro-1,4,5,8-dimethanonaphthalene
1,2,3,4,10,10-Hexachloro-1,4,4a,5,8,8a-hexahydro-1,4-endo-exo-5,8-dimethanonaphthalene
1,2,3,4,10,10-Hexachloro-1,4,4a,5,8,8a-hexahydro-exo-1,4-endo-5,8-dimethanonaphthalene
Aldrex
Aldrex 30
Aldrex 30 E.C.
Aldrin
Aldrin (ACGIH:OSHA)
Aldrine (French)
Aldrite
Aldrosol
Altox
Compound 118
ENT 15,949
Hexachlorohexahydro-endo-exo-dimethanonaphthalene
HHDN
Kortofin
Latka 118 (Czech)
NCI-C00044
Octalene
RCRA waste number P004
SD 2794
Seedrin
Tatuzinho

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	lymphocyte/human	19125 µg/L	MUREAV 31,103,1975
Cytogenetic Analysis	leukocyte/human	19125 µg/L	PHTHDT 6,147,1979
Cytogenetic Analysis	intraperitoneal/rat	9560 µg/kg	PHTHDT 6,147,1979
Cytogenetic Analysis	intraperitoneal/mouse	9560 µg/kg	PHTHDT 6,147,1979
Cytogenetic Analysis	oral/mouse	13 mg/kg	IMSCE2 14,1125,1986
DNA Damage	liver/rat	300 µmol/L	SinJF# 26OCT1982
DNA inhibition	other cell types/rat	100 mg/L	ARTODN 45,101,1980
DNA inhibition	lymphocyte/human	100 mg/L	ARTODN 45,101,1980
micronucleus test	intraperitoneal/other fish	3000 ppm	NULSAK 28,176,1985
mutation in microorganisms	/Saccharomyes cerevisiae	5 ppm (-enzymatic activation step)	RSTUDV 6,161,1976
other mutation test systems	oral/mouse	10 mg/kg	MUREAV 343,157,1995
Unscheduled DNA Synthesis	fibroblast/human	1 µmol/L	MUREAV 42,161,1977
Unscheduled DNA Synthesis	oral/mouse	11 µmol/kg	CRNGDP 8,1433,1987

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
intraperitoneal/rat	1950 µg/kg (13D male)	Reproductive: Other effects on male Endocrine: Androgenic	ANDRDQ 20,472,1988
intraperitoneal/rat	3900 µg/kg (26D male)	Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands	ANDRDQ 20,472,1988
oral/mouse	25 mg/kg (9D pregnant)	Reproductive: Specific developmental abnormalities: Eye, ear Reproductive: Specific developmental abnormalities: Musculoskeletal system	TJADAB 9,11,1974
oral/Dog	73 mg/kg (44W prior to copulation/1-8W pregnant)	Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)	JAVMA4 123,28,1953
oral/hamster	50 mg/kg (7D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Effects on embryo or fetus: Fetal death	TJADAB 9,11,1974
oral/hamster	50 mg/kg (7D pregnant)	Reproductive: Specific developmental abnormalities: Eye, ear Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)	TJADAB 9,11,1974
subcutaneous/rat	10 mg/kg (2D prior to copulation)	Reproductive: Maternal effects: Uterus, cervix, vagina	ENVRAL 16,131,1978
subcutaneous/rat	22 mg/kg (1-22D pregnant)	Reproductive: Effects on newborn: Behavioral	BJMRDK 22,979,1989
subcutaneous/rat	21 mg/kg (21D after birth)	Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Behavioral	BJMRDK 22,979,1989

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
oral/mouse	lowest published toxic dose: 270 mg/kg/80W- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors	NCITR* NCI-TR-21,1978
oral/mouse	toxic dose: 540 mg/kg/80W- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors	NCITR* NCI-TR-21,1978
oral/rat	toxic dose: 188 mg/kg/2Y- continuous	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Liver: Multiple effects Lung, Thorax, or Respiration: Other changes	TXAPA9 11,88,1967
oral/rat	lowest published toxic dose: 200 mg/kg/2Y- continuous	Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors Skin and Appendages: Tumors	FCTXAV 2,551,1964

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Mouse, fibroblast	Inhibitor Concentration (10 percent kill): 33 µmol/L/24H	In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.	TIVIEQ 2,1,1988
In Vitro/Mouse, fibroblast	Inhibitor Concentration (50 percent kill): 61 µmol/L/24H	In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.	TIVIEQ 2,1,1988
In Vitro/Mouse, fibroblast	Inhibitor Concentration (10 percent kill): 14 µmol/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 2,1,1988
In Vitro/Mouse, fibroblast	Inhibitor Concentration (50 percent kill): 55 µmol/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 2,1,1988
inhalation/cat	lethal concentration (50 percent kill): 20 mg/m³		VCVGH* -,567,1990
inhalation/mouse	lethal concentration (50 percent kill): 3 mg/m³		VCVGH* -,567,1990
inhalation/rat	lethal concentration (50 percent kill): 90 mg/m³		VCVGH* -,567,1990
inhalation/rat	Lowest published lethal concentration: 5800 µg/m³/4H		85GMAT -,73,1982
intracerebral/mouse	lethal dose (50 percent kill): 4 mg/kg	Behavioral: Convulsions or effect on seizure threshold	TOLED5 60,289,1992
intraperitoneal/Dog	lethal dose (50 percent kill): 1999 mg/kg	Liver: Liver function tests impaired	TXAPA9 10,119,1967
intraperitoneal/mouse	lethal dose (50 percent kill): 50 mg/kg		SOGEBZ 2,80,1966
intraperitoneal/rat	lethal dose (50 percent kill): 150 mg/kg		TXAPA9 11,302,1967
intravenous/mouse	lethal dose (50 percent kill): 21 mg/kg		32ZDAL -,52,1970
oral/cat	lowest published lethal dose: 15 mg/kg	Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Liver: Fatty liver degeneration Kidney, Ureter, and Bladder: Other changes	CVETAA 2,71,1958
oral/chicken	lethal dose (50 percent kill): 10 mg/kg	Behavioral: Convulsions or effect on seizure threshold Behavioral: Excitement Behavioral: Change in motor activity (specific assay)	JEENAI 45,121,1952
oral/child	lowest published lethal dose: 1250 µg/kg		34ZIAG -,82,1969
oral/Dog	lethal dose (50 percent kill): 65 mg/kg		PCOC** -,7,1966
oral/duck	lethal dose (50 percent kill): 520 mg/kg		DOEAAH 35,25,1979
oral/guinea pig	lethal dose (50 percent kill): 33 mg/kg		PCOC** -,7,1966
oral/hamster	lethal dose (50 percent kill): 100 mg/kg		TJADAB 9,11,1974
oral/human	lowest published toxic dose: 14 mg/kg	Behavioral: Tremor Behavioral: Excitement Gastrointestinal: Nausea or vomiting	34ZIAG -,82,1969
oral/mouse	lethal dose (50 percent kill): 18 mg/kg		VCVGH* -,567,1990
oral/pigeon	lethal dose (50 percent kill): 56200 µg/kg		ASTTA8 (680),157,1979
oral/quail	lethal dose (50 percent kill): 42100 µg/kg		ASTTA8 (680),157,1979
oral/rabbit	lethal dose (50 percent kill): 50 mg/kg		PCOC** -,7,1966
oral/rat	lethal dose (50 percent kill): 38 mg/kg		HBPTO* 2,1136,2001
oral/wild bird	lethal dose (50 percent kill): 7200 µg/kg		TXAPA9 21,315,1972
skin/cat	lethal dose (50 percent kill): 75 mg/kg		VCVGH* -,567,1990
skin/cat	lowest published lethal dose: 75 mg/kg	Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Liver: Fatty liver degeneration Kidney, Ureter, and Bladder: Other changes	CVETAA 2,71,1958
skin/rabbit	lethal dose (50 percent kill): 15 mg/kg	Olfaction: Other olfaction effects Behavioral: Convulsions or effect on seizure threshold Behavioral: Excitement	JEENAI 46,702,1953
skin/rabbit	lethal dose (50 percent kill): 84 mg/kg		VCVGH* -,567,1990
skin/rat	lethal dose (50 percent kill): 98 mg/kg		TXAPA9 14,515,1969
subcutaneous/rabbit	lowest published lethal dose: 100 mg/kg		85GMAT -,73,1982
subcutaneous/rat	lethal dose (50 percent kill): 62 mg/kg		85GMAT -,73,1982
unreported route/Dog	lowest published lethal dose: 95 mg/kg		AMIHBC 3,64,1951
unreported route/mammal (species unspecified)	lethal dose (50 percent kill): 40 mg/kg		30ZDA9 -,62,1971

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
intramuscular/rat	lowest published toxic dose: 290 mg/kg/58D- intermittent	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases	AMIHBC 9,306,1954
intraperitoneal/rat	lowest published toxic dose: 1950 µg/kg/13D- intermittent	Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases	ENVPAF 51,87,1988
intraperitoneal/rat	lowest published toxic dose: 3900 µg/kg/26D- intermittent	Related to Chronic Data: Changes in testicular weight	ENVPAF 51,87,1988
intraperitoneal/rat	lowest published toxic dose: 1950 mg/kg/13D- intermittent	Endocrine: Change in LH Endocrine: Androgenic Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	JOENAK 119,75,1988
intraperitoneal/rat	lowest published toxic dose: 3900 mg/kg/26D- intermittent	Endocrine: Change in gonadotropins	JOENAK 119,75,1988
oral/cat	lowest published toxic dose: 91500 µg/kg/61D- intermittent	Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change Behavioral: Convulsions or effect on seizure threshold Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	CVETAA 2,71,1958
oral/Dog	lowest published toxic dose: 81120 µg/kg/68W- intermittent	Liver: Changes in liver weight	JAFCAU 3,402,1955
oral/mouse	lowest published toxic dose: 66 mg/kg/3D- intermittent	Liver: Hepatitis (hepatocellular necrosis), zonal Liver: Other changes Liver: Changes in liver weight	TXCYAC 249,176,2008
oral/rat	lowest published toxic dose: 9100 µg/kg/26W- intermittent	Endocrine: Other changes Blood: Other changes	GISAAA 31(4),13,1966
oral/rat	lowest published toxic dose: 109 mg/kg/2Y- continuous	Liver: Changes in liver weight	JAFCAU 3,402,1955
oral/rat	lowest published toxic dose: 348 mg/kg/58D- continuous	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases	AMIHBC 9,306,1954

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.05 mg/m³ (inhal, vapor, skin)	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Confirmed animal carcinogen	DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Limited Evidence	IMSUDL 7,88,1987
International Agency for Research on Cancer (IARC)	Cancer Review:Human Inadequate Evidence	IMEMDT 5,25,1974
International Agency for Research on Cancer (IARC)	Cancer Review:Group 3	IMSUDL 7,88,1987
TOXICOLOGY REVIEW		TOLED5 127,101,2002
TOXICOLOGY REVIEW		RREVAH 48,141,1973
TOXICOLOGY REVIEW		RREVAH 56,107,1975
TOXICOLOGY REVIEW		DTTIAF 80,485,1973
TOXICOLOGY REVIEW		BNYMAM 54,413,1978
TOXICOLOGY REVIEW		85CVA2 5,250,1970
TOXICOLOGY REVIEW		CTOXAO 13,231,1978
TOXICOLOGY REVIEW		EESADV 1,89,1977
TOXICOLOGY REVIEW		TXAPA9 10,613,1967
TOXICOLOGY REVIEW		NTIS** PB82-219007
TOXICOLOGY REVIEW		EVHPAZ 109(Suppl 1),113,2001
TOXICOLOGY REVIEW		MUREAV 567,109,2004
TOXICOLOGY REVIEW		26UZAB 6,149,1968/1970
TOXICOLOGY REVIEW		MUTAEX 21,93,2006
TOXICOLOGY REVIEW		ENTOX* -,66,2005
TOXICOLOGY REVIEW		MUREAV 584,1,2005
TOXICOLOGY REVIEW		ENTOX* -,334,2005
TOXICOLOGY REVIEW		HETOEA 25,413,2006
TOXICOLOGY REVIEW		MUREAV 654,114,2008
TOXICOLOGY REVIEW		TPHSDY 29,322,2008
TOXICOLOGY REVIEW		FCTOD7 46,813,2008
TOXICOLOGY REVIEW		MUREAV 674,36,2009

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Cancelled	RBREV* -,83,1998
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 0.25 mg/m³ (skin)	DTLVS* 3,7,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.25 mg/m³, JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.25 mg/m³;KZW 2.5 mg/m³, inhal, skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 0.25 mg/m³, Skin, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.25 mg/m³, skin, carc, MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 0.25 mg/m³, short term exposure limit 0.75 mg/m³, skin, NOV2011
Occupational Exposure Limit-FRANCE	VME 0.25 mg/m³, Skin, C3 Carcinogen, FEB2006
Occupational Exposure Limit-GERMANY	MAK 0.25 mg/m³, inhal, skin, 2011
Occupational Exposure Limit-ICELAND	time-weighted average 0.25 mg/m³, skin, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 0.25 mg/m³, skin, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 0.25 mg/m³;short term exposure limit 0.75 mg/m³ (skin), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.25 mg/m³, skin, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 0.25 mg/m³, JAN1999
Occupational Exposure Limit-PERU	time-weighted average 0.25 mg/m³, JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 0.5 mg/m³, short term exposure limit 1.5 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	time-weighted average 0.01 mg/m³, short term exposure limit 0.03 mg/m³, Skin, JUN2003
Occupational Exposure Limit-SWITZERLAND	MAK-week 0.25 mg/m³, carc 3, inhal, skin, JAN2011
Occupational Exposure Limit-THAILAND	time-weighted average 0.25 mg/m³, JAN1993
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 0.25 mg/m³, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 0.25 mg/m³, Skin, JAN1993
Occupational Exposure Limit-TURKEY	time-weighted average 0.25 mg/m³, Skin, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 0.25 mg/m³ (skin)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 0.25 mg/m³ (skin)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 0.25 mg/m³ (skin)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 0.25 mg/m³ (skin)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ALDRIN-air	10H Carcinogen time-weighted average 0.25 mg/m³ (Sk) (0.15 mg/m³ LOQ)	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 04260; Number of Industries 1; Total Number of Facilities 7; Number of Occupations 2; Total Number of Employees Exposed 42; Total Number of Female Employees Exposed 7
National Occupational Hazard Survey 1974	Hazard Code 04260; Number of Industries 1; Total Number of Facilities 43; Number of Occupations 8; Total Number of Employees Exposed 605

Status in Federal Agencies

Organization	Reference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/182368/AS)
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);clear evidence:mouse	NCITR* NCI-TR-21,1978
NCI Carcinogenesis Bioassay (feed);equivocal evidence:rat	NCITR* NCI-TR-21,1978
NIOSH Analytical Method, 1994: Aldrin, 5502
On EPA IRIS database

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Page last reviewed:March 7, 2014
Page last updated:February 6, 2017
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