Registry of Toxic Effects of Chemical Substances (RTECS)
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Disulfide, bis(dimethylthiocarbamoyl)
RTECS #
JO1400000CAS #
137-26-8; 12680-07-8; 12680-62-5; 39456-80-9; 66173-72-6; 93196-73-7Updated
September 201Molecular Weight
240.44Molecular Formula
C6H12N2S4Synonyms
Accelerator thiuramAceto TETD
alpha,alpha'-Dithiobis(dimethylthio)formamide
Arasan
Arasan 42-S
Arasan 70
Arasan 75
Arasan-M
Arasan-SF
Arasan-SF-X
Aules
Bis((dimethylamino)carbonothioyl) disulphide
Bis(dimethylthiocarbamoyl) disulfide
Bis(dimethylthiocarbamoyl) disulphide
Bis(dimethyl-thiocarbamoyl)-disulfid (German)
Bis(dimethylthiocarbamyl) disulfide
Chipco thiram 75
Cyuram DS
Disolfuro di tetrametiltiourame (Italian)
Disulfure de tetramethylthiourame (French)
Ekagom TB
Falitiram
Fermide
Fernacol
Fernasan
Fernasan A
Fernide
Flo Pro T Seed Protectant
FMC 2070
Formamide, 1,1'-dithiobis(N,N-dimethylthio-
Hermal
Hermat TMT
Heryl
Hexathir
Kregasan
Mercuram
Methyl thiram
Methyl thiuramdisulfide
Methyl tuads
Micropearls
N,N'-(Dithiodicarbonothioyl)bis(N-methylmethanamine)
N,N,N',N'-Tetramethylthiuram disulfide
N,N-Tetramethylthiuram disulphide
Nobecutan
Nomersan
Normersan
Panoram 75
Polyram ultra
Pomarsol
Pomarsol forte
Pomasol
Puralin
Radothiram
RCRA waste number U244
Rezifilm
Royal TMTD
Sadoplon
Spotrete
Spotrete-F
SQ 1489
Tersan
Tersan 75
Tetramethyl thiurane disulfide
Tetramethyl thiurane disulphide
Tetramethyldiurane sulphite
Tetramethylenethiuram disulphide
Tetramethylthiocarbamoyldisulphide
Tetramethylthioperoxydicarbonic diamide
Tetramethylthioramdisulfide (Dutch)
Tetramethyl-thiram disulfid (German)
Tetramethylthiuram bisulfide
Tetramethylthiuram bisulphide
Tetramethylthiuram disulfide
Tetramethylthiuram disulphide
Tetramethylthiuran disulphide
Tetramethylthiurum disulfide
Tetramethylthiurum disulphide
Tetrapom
Tetrathiuram disulfide
Tetrathiuram disulphide
Thillate
Thimer
Thioknock
Thiosan
Thiotox (fungicide)
Thiram
Thiram (ACGIH:OSHA)
Thiram 75
Thiram B
Thiramad
Thirame (French)
Thirasan
Thiulix
Thiurad
Thiuram
Thiuram D
Thiuram disulfide, tetramethyl-
Thiuram M
Thiuram M rubber accelerator
Thiuramin
Thiuramyl
Thylate
Tigam
Tirampa
Tiuram (Polish)
Tiuramyl
TMTD
TMTDS
Trametan
Tridipam
Tripomol
Tuads
TUEX
Tulisan
USAF B-30
USAF EK-2089
USAF P-5
Vancida TM-95
Vancide TM
VUAgT-I-4
Vulcafor TMTD
Vulkacit MTIC
Vulkacit thiuram
Vulkacit thiuram/C
ZUPA S 80
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /rabbit | 100 mg/24H | moderate | 28ZPAK -,278,1972 |
| eye /rabbit | 100% | HPV407 -,-,2001 | |
| eye /rabbit | 100 mg | mild | HPV407 -,-,2001 |
| skin /rabbit | 100% | mild | HPV407 -,-,2001 |
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| Cytogenetic Analysis | oral/mouse | 80 mg/kg/3D-continuous | FCTOD7 25,709,1987 |
| Cytogenetic Analysis | ovary/hamster | 5600 µg/L (+/-enzymatic activation step) | HPV407 ,,2001 |
| DNA Damage | oral/mouse | 2400 mg/kg/8D-continuous | FCTOD7 36,155,1998 |
| DNA Damage | lymphocyte/human | 100 µg/L | FCTOD7 36,155,1998 |
| DNA inhibition | lymphocyte/human | 1 mg/L | ARTODN 45,101,1980 |
| DNA inhibition | other cell types/rat | 100 µg/L | ARTODN 45,101,1980 |
| DNA repair | /Salmonella typhimurium | 50 µg/plate | MUREAV 89,1,1981 |
| DNA repair | /Bacillus subtilis | 2 µg/disc | MUREAV 40,19,1976 |
| Dominant Lethal Test | oral/mouse | 150 mg/kg/8W-continuous | FCTOD7 35,523,1997 |
| micronucleus test | intraperitoneal/mouse | 100 mg/kg | FCTOD7 23,373,1985 |
| micronucleus test | lymphocyte/human | 5 mg/L | FCTOD7 36,155,1998 |
| morphological transform | oral/rat | 2520 mg/kg/6W | CRNGDP 9,387,1988 |
| mutation in mammalian somatic cells | lung/hamster | 5 mg/L | FCTOD7 23,373,1985 |
| mutation in microorganisms | /Salmonella typhimurium | 50 µg/plate (+/-enzymatic activation step) | HPV407 ,,2001 |
| mutation in microorganisms | /Other microorganisms | 1000 ppm (-enzymatic activation step) | MMAPAP 50,233,1973 |
| mutation in microorganisms | /Aspergillus nidulans | 500 ng/plate (-enzymatic activation step) | MUREAV 89,1,1981 |
| mutation in microorganisms | /Salmonella typhimurium | 50 µg/plate (+enzymatic activation step) | MUREAV 68,9,1979 |
| mutation in microorganisms | /Salmonella typhimurium | 5 µg/plate (-enzymatic activation step) | MUREAV 68,313,1979 |
| phage inhibition capacity | /Escherichia coli | 1 µg/tube | MUREAV 89,1,1981 |
| sex chromosome loss and nondisjunction | /Aspergillus nidulans | 20 ppm | MUREAV 89,297,1981 |
| sex chromosome loss and nondisjunction | oral/Drosophila melanogaster | 4 gm/L | SWEHDO 9(Suppl 2),27,1983 |
| sperm morphology | intraperitoneal/mouse | 100 mg/kg | PMRSDJ 2,79,1981 |
| sperm morphology | oral/mouse | 80 mg/kg/3D-continuous | FCTOD7 25,709,1987 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/rat | 1200 mg/kg (7-12D pregnant) | Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) | TXAPA9 35,83,1976 |
| oral/rat | 300 mg/kg (15D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Other developmental abnormalities | GISAAA 43(6),37,1978 |
| oral/rat | 1190 mg/kg (16-22D preg/21D after birth) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | TXAPA9 35,83,1976 |
| oral/rat | 550 mg/kg (1-22D pregnant) | Reproductive: Effects on newborn: Behavioral | AEEDDS 2,215,1976 |
| oral/rat | 420 mg/kg (1-20D pregnant) | Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system Reproductive: Effects on newborn: Biochemical and metabolic | GISAAA 51(6),23,1986 |
| oral/rat | 1800 mg/kg (1Y male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct | IJEBA6 36,390,1998 |
| oral/mouse | 100 mg/kg (6-15D pregnant) | Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Specific developmental abnormalities: Musculoskeletal system | ATXKA8 30,251,1973 |
| oral/mouse | 300 mg/kg (6-15D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | ATXKA8 30,251,1973 |
| oral/mouse | 80 mg/kg (3D male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | FCTOD7 25,709,1987 |
| oral/hamster | 125 mg/kg (7D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system | TXAPA9 15,152,1969 |
| oral/hamster | 250 mg/kg (8D pregnant) | Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) | TXAPA9 15,152,1969 |
| oral/hamster | 250 mg/kg (7D pregnant) | Reproductive: Specific developmental abnormalities: Body wall | TXAPA9 15,152,1969 |
| oral/hamster | 300 mg/kg (7D pregnant) | Reproductive: Specific developmental abnormalities: Central nervous system | TXAPA9 15,152,1969 |
| oral/mammal (species unspecified) | 848 mg/kg (60D prior to copulation/1-53D pregnant) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | TOXID9 4,20,1984 |
| oral/rat | 125 mg/kg (6-10D pregnant) | Reproductive: Maternal effects: Parturition Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | TOXID9 44,229,2005 |
| oral/rat | 291.6 mg/kg (multigeneration) | Reproductive: Other effects on male Reproductive: Other effects on female | HPV407 -,-,2001 |
| oral/rat | 150 mg/kg (6-15D pregnant) | Reproductive: Other effects on male Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system | HPV407 -,-,2001 |
| oral/hamster | 250 mg/kg (7-8D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Other developmental abnormalities | HPV407 -,-,2001 |
| oral/hamster | 500 mg/kg (7-8D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Other developmental abnormalities | HPV407 -,-,2001 |
| parenteral/rat | 400 mg/kg (4-11D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Effects on embryo or fetus: Fetal death | BEXBAN 93,107,1982 |
| parenteral/rat | 800 mg/kg (2D male/2D prior to copulation) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Effects on embryo or fetus: Fetal death | BEXBAN 93,107,1982 |
| subcutaneous/mouse | 90 mg/kg (6-14D pregnant) | Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) | NTIS** PB223-160 |
| subcutaneous/mouse | 1035 mg/kg (6-14D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | NTIS** PB223-160 |
| unreported route/rat | 50 mg/kg (1D prior to copulation) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetal death | HBPTO* 1,738,2001 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/rat | lowest published toxic dose: 108 mg/kg/1Y- continuous | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Skin and Appendages: Tumors | RPZHAW 31,67,1980 |
| skin/mouse | lowest published toxic dose: 100 mg/kg | Nutritional and Gross Metabolic: Conditioned vitamin deficiency Skin and Appendages: Tumors | FCTOD7 34,283,1996 |
| skin/mouse | toxic dose: 15300 mg/kg/51W- intermittent | Tumorigenic: Neoplastic by RTECS criteria Skin and Appendages: Tumors | FCTOD7 34,283,1996 |
| subcutaneous/mouse | lowest published toxic dose: 46 mg/kg | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors Blood: Tumors | NTIS** PB223-159 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/human | lowest published toxic concentration: 30 µg/m3/5Y- intermittent | Eye: Conjunctiva irritation Cardiac: Other changes Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi | VRDEA5 (10),136,1971 |
| inhalation/rat | lethal concentration (50 percent kill): 4420 mg/m3/4H | Eye: Lacrimation Behavioral: Somnolence (general depressed activity) Kidney, Ureter, and Bladder: Urine volume increased | HPV407 -,-,2001 |
| inhalation/rat | lethal dose (50 percent kill): 4400 mg/kg | HPV407 -,-,2001 | |
| intraperitoneal/mouse | lethal dose (50 percent kill): 70 mg/kg | HPV407 -,-,2001 | |
| intraperitoneal/rat | lethal dose (50 percent kill): 138 mg/kg | HPV407 -,-,2001 | |
| intraperitoneal/rat | lethal dose (50 percent kill): 138 mg/kg | Behavioral: Change in motor activity (specific assay) Nutritional and Gross Metabolic: Body temperature decrease | JNPHAG 9,35,1978 |
| intraperitoneal/rat | lowest published toxic dose: 24 mg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) | TOXID9 66,126,2002 |
| intraperitoneal/rat | lowest published toxic dose: 120 mg/kg | Liver: Hepatitis (hepatocellular necrosis), zonal Liver: Liver function tests impaired | TOXID9 66,126,2002 |
| oral/cat | lowest published lethal dose: 230 mg/kg | Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia Behavioral: Analgesia | JPETAB 17,349,1921 |
| oral/mouse | lethal dose (50 percent kill): 1250 mg/kg | Behavioral: Somnolence (general depressed activity) Skin and Appendages: Other: Hair | GTPZAB 6(7),28,1962 |
| oral/mouse | lethal dose (50 percent kill): 1350 mg/kg | HPV407 -,-,2001 | |
| oral/rabbit | lethal dose (50 percent kill): 210 mg/kg | KOKABN 26,358,1977 | |
| oral/rat | lethal dose (50 percent kill): 560 mg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TXAPA9 11,546,1967 |
| oral/rat | lethal dose (50 percent kill): 1800 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Tremor Lung, Thorax, or Respiration: Respiratory depression | HPV407 -,-,2001 |
| oral/rat | lethal dose (50 percent kill): 560 mg/kg | HPV407 -,-,2001 | |
| oral/wild bird | lethal dose (50 percent kill): 300 mg/kg | AECTCV 12,355,1983 | |
| skin/rabbit | lowest published lethal dose: 1000 mg/kg | HPV407 -,-,2001 | |
| skin/rat | lethal dose (50 percent kill): >5000 mg/kg | HPV407 -,-,2001 | |
| skin/rat | lowest published lethal dose: 5 gm/kg | Behavioral: Somnolence (general depressed activity) | ATDAEI 15(Suppl 1),S76,1996 |
| subcutaneous/mouse | lethal dose (50 percent kill): 1109 mg/kg | NNGADV 15,507,1990 | |
| subcutaneous/rat | lethal dose (50 percent kill): 646 mg/kg | HPV407 -,-,2001 | |
| unreported route/chicken | lethal dose (50 percent kill): 840 mg/kg | VETNAL 54(2),70,1978 | |
| unreported route/domestic animal | lethal dose (50 percent kill): 225 mg/kg | VETNAL 54(2),70,1978 | |
| unreported route/mammal (species unspecified) | lethal dose (50 percent kill): 400 mg/kg | GISAAA 45(5),29,1980 | |
| unreported route/mouse | lethal dose (50 percent kill): 1150 mg/kg | KOKABN 26,358,1977 | |
| unreported route/rabbit | lethal dose (50 percent kill): 210 mg/kg | VETNAL 54(2),70,1978 | |
| unreported route/rat | lethal dose (50 percent kill): 740 mg/kg | KOKABN 26,358,1977 | |
| unreported route/rat | lowest published toxic dose: 50 mg/kg | Endocrine: Evidence of thyroid hypofunction | HBPTO* 1,738,2001 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | lowest published toxic concentration: 91 mg/m3/26W- intermittent | Cardiac: Other changes | TPKVAL 15,3,1979 |
| oral/Dog | lowest published toxic dose: 29120 mg/kg/2Y- intermittent | Eye: Retinal changes pigmentary deposition, retinitis, other) Blood: Changes in erythrocyte (RBC) count Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | JTSCDR 5,269,1980 |
| oral/Dog | lowest published toxic dose: 1120 mg/kg/4W- intermittent | Eye: Retinal changes pigmentary deposition, retinitis, other) Gastrointestinal: Nausea or vomiting Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NNGADV 15,507,1990 |
| oral/mouse | lowest published toxic dose: 12222 mg/kg/97W- intermittent | Behavioral: Food intake (animal) Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HPV407 -,-,2001 |
| oral/mouse | lowest published toxic dose: 24444 mg/kg/97W- intermittent | Behavioral: Food intake (animal) Blood: Changes in spleen Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HPV407 -,-,2001 |
| oral/mouse | lowest published toxic dose: 48888 mg/kg/97W- intermittent | Blood: Normocytic anemia Blood: Changes in spleen Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HPV407 -,-,2001 |
| oral/mouse | lowest published toxic dose: 1560 µg/kg/3D- intermittent | Vascular: Other changes | BJCAAI 86,779,2002 |
| oral/mouse | lowest published toxic dose: 12000 µg/kg/4W- intermittent | Vascular: Other changes Tumorigenic: Tumor types after systemic administration not seen spontaneously | BJCAAI 86,779,2002 |
| oral/mouse | lowest published toxic dose: 4680 µg/kg/3W- intermittent | Liver: Other changes Tumorigenic: Tumor types after systemic administration not seen spontaneously | BJCAAI 86,779,2002 |
| oral/pig | lowest published toxic dose: 1820 µg/kg/1Y- continuous | Cardiac: Arrythmias (indlucing changes in conduction) Cardiac: Other changes | CUTOEX 1,221,1993 |
| oral/rabbit | lowest published toxic dose: 1520 mg/kg/15W- intermittent | Vascular: BP lowering not characterized in autonomic section Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | GTPZAB 6(7),28,1962 |
| oral/rat | lowest published toxic dose: 125 mg/kg/5D- intermittent | Endocrine: Change in LH | TOXID9 44,229,2005 |
| oral/rat | lowest published toxic dose: 387.5 mg/kg/31D- intermittent | Endocrine: Other changes | TOXID9 44,352,2005 |
| oral/rat | lowest published toxic dose: 1550 mg/kg/31D- intermittent | Endocrine: Change in LH | TOXID9 44,352,2005 |
| oral/rat | lowest published toxic dose: 3200 mg/kg/4D- intermittent | Liver: Changes in liver weight | TOXID9 66,339,2002 |
| oral/rat | lowest published toxic dose: 1000 mg/kg/4D- intermittent | Endocrine: Evidence of thyroid hypofunction | TOXID9 66,339,2002 |
| oral/rat | lowest published toxic dose: 2250 mg/kg/90D- intermittent | Gastrointestinal: Gastritis Blood: Changes in erythrocyte (RBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HPV407 -,-,2001 |
| oral/rat | lowest published toxic dose: 5.46 gm/kg/13W- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HPV407 -,-,2001 |
| oral/rat | lowest published toxic dose: 13.65 gm/kg/13W- intermittent | Reproductive: Paternal effects: Testes, epididymis, sperm duct Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | HPV407 -,-,2001 |
| oral/rat | lowest published toxic dose: 3.276 gm/kg/13W- intermittent | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | HPV407 -,-,2001 |
| oral/rat | lowest published toxic dose: 6552 mg/kg/104W- intermittent | Blood: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HPV407 -,-,2001 |
| oral/rat | lowest published toxic dose: 13104 mg/kg/104W- intermittent | Blood: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | HPV407 -,-,2001 |
| oral/rat | lowest published toxic dose: 450 mg/kg/90D- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | INHEAO 31,59,1993 |
| oral/rat | lowest published toxic dose: 406 mg/kg/14D- intermittent | Liver: Other changes Blood: Other changes Biochemical: Metabolism (intermediary): Lipids including transport | BCTKAG 17,69,1984 |
| oral/rat | lowest published toxic dose: 350 mg/kg/7D- continuous | Brain and Coverings: Other degenerative changes Kidney, Ureter, and Bladder: Other changes Nutritional and Gross Metabolic: Changes in: Other metals | ARTODN 48,29,1981 |
| oral/rat | lowest published toxic dose: 10920 mg/kg/2Y- continuous | Behavioral: Food intake (animal) Musculoskeletal: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JTSCDR 5,269,1980 |
| oral/rat | lowest published toxic dose: 1680 mg/kg/4W- continuous | Blood: Changes in erythrocyte (RBC) count Skin and Appendages: Other: Hair Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NNGADV 15,507,1990 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.05 mg/m3 (sen) | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Inadequate Evidence | IMEMDT 12,225,1976 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human No Adequate Data | IMEMDT 12,225,1976 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Inadequate Evidence | IMEMDT 53,403,1991 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human Inadequate Evidence | IMEMDT 53,403,1991 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Group 3 | IMEMDT 53,403,1991 |
| TOXICOLOGY REVIEW | CNDQA8 10(3),43,1975 | |
| TOXICOLOGY REVIEW | MUREAV 567,347,2004 | |
| TOXICOLOGY REVIEW | MUTAEX 21,93,2006 | |
| TOXICOLOGY REVIEW | ENTOX* -,86,2005 | |
| TOXICOLOGY REVIEW | ENTOX* -,179,2005 | |
| TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
| TOXICOLOGY REVIEW | HUTOX* -,561,1996 | |
| TOXICOLOGY REVIEW | HETOEA 26,321,2007 | |
| TOXICOLOGY REVIEW | FEREAC 74,47507,2009 | |
| TOXICOLOGY REVIEW | FEREAC 74,48386,2009 | |
| TOXICOLOGY REVIEW | MUTAEX 21,343,2006 | |
| TOXICOLOGY REVIEW | MUREAV 723,108,2011 | |
| TOXICOLOGY REVIEW | MUREAV 721,27,2011 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | Supported | RBREV* -,154,1998 |
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 5 mg/m3 | DTLVS* 3,257,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 1 mg/m3, JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 5 mg/m3;KZW 25 mg/m3, inhal, sen, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 1 mg/m3, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 1 mg/m3, MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 1 mg/m3, short term exposure limit 2 mg/m3, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 5 mg/m3, FEB2006 | |
| Occupational Exposure Limit-GERMANY | MAK 1 mg/m3, inhal, skin, sen, 2011 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 1 mg/m3, sen, NOV2011 | |
| Occupational Exposure Limit-JAPAN | Occupational Exposure Limit 0.1 mg/m3, s1 sen, MAY2012 | |
| Occupational Exposure Limit-KOREA | time-weighted average 5 mg/m3, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 1 mg/m3, 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 1 mg/m3, JAN2002 | |
| Occupational Exposure Limit-PERU | time-weighted average 1 mg/m3, JUL2005 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 0.5 mg/m3, MAC(short term exposure limit) 2 mg/m3, JAN1999 | |
| Occupational Exposure Limit-RUSSIA | time-weighted average 0.5 mg/m3, short term exposure limit 1.5 mg/m3, Skin, JUN2003 | |
| Occupational Exposure Limit-SWEDEN | time-weighted average 1 mg/m3;short term exposure limit 2 mg/m3, Sen, JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 0.01 mg/m3, inhal, skin, sen, JAN2011 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 1 mg/m3, KZG-week 2 mg/m3, inhal, sen, JAN2011 | |
| Occupational Exposure Limit-THAILAND | time-weighted average 5 mg/m3, JAN1993 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 5 mg/m3, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 5 mg/m3, JAN1993 | |
| Occupational Exposure Limit-TURKEY | time-weighted average 5 mg/m3, JAN1993 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 5 mg/m3 | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 5 mg/m3 | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 5 mg/m3 | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 5 mg/m3 | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THIRAM-air | 10H time-weighted average 5 mg/m3 | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 71900; Number of Industries 23; Total Number of Facilities 2234; Number of Occupations 48; Total Number of Employees Exposed 47798; Total Number of Female Employees Exposed 9520 | |
| National Occupational Hazard Survey 1974 | Hazard Code 71900; Number of Industries 14; Total Number of Facilities 1502; Number of Occupations 37; Total Number of Employees Exposed 17330 |
Status in Federal Agencies
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division