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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethane, 2-bromo-2-chloro-1,1,1-trifluoro-

RTECS #

KH6550000

CAS #

151-67-7

Updated

September 201

Molecular Weight

197.39

Molecular Formula

C2HBrClF3

Synonyms

1,1,1-Trifluoro-2-bromo-2-chloroethane
1,1,1-Trifluoro-2-chloro-2-bromoethane
1-Bromo-1-chloro-2,2,2-trifluoroethane
2,2,2-Trifluoro-1-chloro-1-bromoethane
2-Bromo-2-chloro-1,1,1-trifluoroethane
Bromochlorotrifluoroethane
Chalothane
Ethane, 1-bromo-1-chloro-2,2,2-trifluoro-
Fluorotane
Fluothane
Ftorotan (Russian)
Halotan
Halothane
Halothane (ACGIH)
Halsan
Narcotane
Narcotann NE-spofa (Russian)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg severeFEPRA7 35,729,1976

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human1 pph/48H-continuousNSMZDZ 7,19,1979
Cytogenetic Analysisfibroblast/mouse1000 ppmENVRAL 12,366,1976
Cytogenetic Analysislung/hamster1 pph/48H-continuousNSMZDZ 7,19,1979
Cytogenetic Analysisparenteral/chicken10 mgENVRAL 12,366,1976
DNA inhibitioninhalation/mouse8000 ppm/24H-continuousCNREA8 36,3156,1976
micronucleus testoral/rat4 mmol/kgMUREAV 413,1,1998
other mutation test systemsinhalation/grasshopper46 pph/16HMUREAV 113,467,1983
other mutation test systemsother cell types/non-mammalian species1 mmol/LECREAL 141,492,1982
other mutation test systemsinhalation/mouse1 pph/1HBCPCA6 27,2187,1978
other mutation test systemsfibroblast/hamster1 pphANESAV 43,21,1975
sex chromosome loss and nondisjunctioninhalation/Drosophila melanogaster1 pph/1HANESAV 62,305,1985
sex chromosome loss and nondisjunctionoral/Drosophila melanogaster3450 ppm/24H-continuousMUREAV 91,225,1981
Unscheduled DNA Synthesisinhalation/rat1000 ppm/2H-continuousANESAV 30,401,1969
Unscheduled DNA Synthesisoral/rat10 gm/kgJTEHD6 10,327,1982

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 100 ppm/8H (2-22D preg/30D after birth)Reproductive: Effects on newborn: BehavioralBBREDI 36,147,1990
inhalation/rat 8000 ppm/12H (9D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)		ANESAV 29,1167,1968
inhalation/rat 1600 ppm/8H (1-21D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)ANESAV 48,11,1978
inhalation/rat 10 ppm/8H (1-22D pregnant)Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material)

Reproductive: Specific developmental abnormalities: Central nervous system		ENVRAL 11,40,1976
inhalation/rat 8000 ppm/6H (7-9D pregnant)Reproductive: Effects on fertility: AbortionAAREAV 32,41,1975
inhalation/rat 10 ppm/8H (1-22D pregnant)Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material)

Reproductive: Specific developmental abnormalities: Urogenital system		ENVRAL 10,174,1975
inhalation/mouse 3000 ppm/4H (9W prior to copulation/1-21D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on fertility: Other measures of fertility		ANESAV 48,167,1978
inhalation/mouse 1000 ppm/4H (9W prior to copulation/1-21D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)ANESAV 48,167,1978
inhalation/mouse 1 pph/3H (13D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Other developmental abnormalities		TJADAB 4,242,1971
inhalation/mouse 3000 ppm/4H (9W prior to copulation/1-17D pregnant)Reproductive: Specific developmental abnormalities: Urogenital systemANESAV 51,532,1979
inhalation/mouse 14000 ppm/1H (8-10D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)DABBBA 31,3599,1970
inhalation/mouse 15000 ppm/40M (3W prior to copulation)Reproductive: Other effects on female

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

Reproductive: Effects on newborn: Other postnatal measures or effects		REPTED 13,361,1999

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/child lowest published toxic concentration: 0.9 pphCardiac: Change in rate

Lung, Thorax, or Respiration: Respiratory depression

Biochemical: Metabolism (intermediary): Other		AANEAB 45,639,2001
inhalation/human Lowest published lethal concentration: 7000 ppm/3HLiver: Hepatitis (hepatocellular necrosis), diffuse

Gastrointestinal: Nausea or vomiting

Nutritional and Gross Metabolic: Body temperature increase		ANESAV 24,29,1963
inhalation/mouse lethal concentration (50 percent kill): 98 gm/m3/2HBrain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes		TLSMA6 111,10,1975
inhalation/mouse lethal concentration (50 percent kill): 93600 mg/m3/2HVCVGH* -,644,1990
inhalation/mouse lethal concentration (50 percent kill): 340575 mg/m3/10MVCVGH* -,644,1990
inhalation/mouse lethal concentration (50 percent kill): 270662 mg/m3/30MVCVGH* -,644,1990
inhalation/mouse lethal concentration (50 percent kill): 197421 mg/m3/60MVCVGH* -,644,1990
inhalation/mouse lowest published toxic concentration: 1.21 pph/20MBehavioral: AnalgesiaJPETAB 317,615,2006
inhalation/mouse lowest published toxic concentration: 2960.85 mg/kgLiver: Hepatitis (hepatocellular necrosis), zonal

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases		TOXID9 -,174,2008
inhalation/mouse lowest published toxic concentration: 1.35 pph/20MBehavioral: General anestheticJPETAB 323,924,2007
inhalation/rat lowest published toxic concentration: 10 ppm/2HLiver: Multiple effects

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Metabolism (intermediary): Other		TOXID9 227,53,2006
inhalation/rat lethal concentration (50 percent kill): 120000 mg/m3/4HVCVGH* -,644,1990
inhalation/rat lowest published toxic concentration: 1.5 pph/30MBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes

Biochemical: Metabolism (intermediary): Other		AANEAB 46,378,2002
inhalation/rat lethal concentration (50 percent kill): 29000 ppmFATOAO 25,143,1962
inhalation/rat lowest published toxic concentration: 1.5 pphLiver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport		FATOAO 55,33,1992
intraperitoneal/guinea pig lowest published toxic dose: 1.97 gm/kgLiver: Liver function tests impaired

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Other proteins		CRTOEC 14,362,2001
intraperitoneal/guinea pig lowest published toxic dose: 1974 mg/kgLiver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Other proteins		TOLED5 144,35,2003
intraperitoneal/guinea pig lowest published toxic dose: 1974 mg/kgLiver: Liver function tests impaired

Liver: Other changes

Biochemical: Metabolism (intermediary): Other		TOXID9 1,87,2001
intraperitoneal/mouse lowest published toxic dose: 1870 mg/kgLiver: Fatty liver degenerationVCVGH* -,644,1990
intraperitoneal/mouse lowest published toxic dose: 986.95 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: TransaminasesTOXID9 -,238,2009
intraperitoneal/mouse lowest published toxic dose: 2960.85 mg/kgLiver: Hepatitis (hepatocellular necrosis), zonal

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation		TOXID9 -,238,2009
intraperitoneal/mouse lowest published toxic dose: 2961 mg/kgLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation		TOXID9 -,391,2009
intraperitoneal/rat lowest published toxic dose: 1974 mg/kgLiver: Other changes

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)		TOXID9 60,227,2001
intravenous/man lowest published lethal dose: 129 mg/kgBehavioral: General anesthetic

Cardiac: Change in rate

Lung, Thorax, or Respiration: Cyanosis		LANCAO 1,340,1982
oral/guinea pig lethal dose (50 percent kill): 6 gm/kgBehavioral: Excitement

Behavioral: Antipsychotic		GTPZAB 24(3),36,1980
oral/guinea pig lethal dose (50 percent kill): 6000 mg/kgVCVGH* -,644,1990
oral/rat lethal dose (50 percent kill): 5680 mg/kgBehavioral: Excitement

Behavioral: Antipsychotic		GTPZAB 24(3),36,1980
oral/rat lethal dose (50 percent kill): 5680 mg/kgVCVGH* -,644,1990
unreported route/woman lowest published lethal dose: 0.4 mL/kgVascular: Regional or general arteriolar or venous dilation

Blood: Hemorrhage		JFSCAS 45,923,2000

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lowest published toxic concentration: 1 pph/4H/80D- intermittentLiver: Other changes

Immunological Including Allergic: Increase in cellular immune response

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases		TXAPA9 143,245,1997
inhalation/guinea pig lowest published toxic concentration: 50 ppm/24H/5W- continuousLiver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		ANESAV 42,408,1975
inhalation/guinea pig lowest published toxic concentration: 10000 ppm/1H/7D- intermittentLiver: Other changes

Nutritional and Gross Metabolic: Conditioned vitamin deficiency

Biochemical: Effect on specific coenzyme: Other coenzymes		JJATDK 9,9,1989
inhalation/mouse lowest published toxic concentration: 300 ppm/24H/5W- continuousLiver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		ANESAV 42,408,1975
inhalation/rat lowest published toxic concentration: 200 mg/m3/16W- continuousImmunological Including Allergic: Other immediate (humoral): uticaria, allergic rhinitis, serum sickness (multiple organ involvement)VCVGH* -,645,1990
inhalation/rat lowest published toxic concentration: 15 ppm/4H/9W- intermittentLiver: Liver function tests impaired

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)		TOLED5 144,105,2003
inhalation/rat lowest published toxic concentration: 50 ppm/24H/4W- continuousLiver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Fatty liver degeneration

Liver: Changes in liver weight		PHTOEH 62,74,1988
inhalation/rat lowest published toxic concentration: 10000 ppm/1H/7D- intermittentLiver: Other changes

Nutritional and Gross Metabolic: Conditioned vitamin deficiency		JJATDK 9,9,1989
inhalation/rat lowest published toxic concentration: 300 ppm/24H/5W- continuousLiver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		ANESAV 42,408,1975
inhalation/rat lowest published toxic concentration: 2500 ppm/8H/8W- intermittentBrain and Coverings: Other degenerative changes

Kidney, Ureter, and Bladder: Urine volume increased

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites		EXNEAC 76,168,1982
inhalation/rat lowest published toxic concentration: 5126 mg/m3/4H/17W- intermittentBrain and Coverings: Recordings from specific areas of CNS

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase		GTPZAB 24(3),36,1980
inhalation/rat lowest published toxic concentration: 500 ppm/6H/9D- intermittentGastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases		DTESD7 11,407,1983

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 50 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMSUDL 7,93,1987
TOXICOLOGY REVIEWMUREAV 566,21,2004
TOXICOLOGY REVIEWINTEAG 15,7,1974
TOXICOLOGY REVIEWARMCAH 25,411,1974
TOXICOLOGY REVIEWCJSUAX 15,217,1972
TOXICOLOGY REVIEWAASXAP 49,1,1971
TOXICOLOGY REVIEWAACRAT 57,328,1978
TOXICOLOGY REVIEWMUREAV 488,151,2001
TOXICOLOGY REVIEWTPHSDY 23,374,2002
TOXICOLOGY REVIEWTPHSDY 23,519,2002
TOXICOLOGY REVIEWCRTXB2 33,105,2003
TOXICOLOGY REVIEWTPHSDY 23,552,2002
TOXICOLOGY REVIEWEMMUEG 43,143,2004
TOXICOLOGY REVIEWTPHSDY 24,648,2003
TOXICOLOGY REVIEWAINCM* 7,63,2006
TOXICOLOGY REVIEWDIMON* 39,678,1993
TOXICOLOGY REVIEWENTOX* -,125,2005
TOXICOLOGY REVIEWEJPHAZ 549,1,2006
TOXICOLOGY REVIEWHUTOX* -,577,1996
TOXICOLOGY REVIEWBLREV* 3,71,1989
TOXICOLOGY REVIEWCLLID* 13,277,2009
TOXICOLOGY REVIEWNCLNA* 16,503,1998
TOXICOLOGY REVIEWNEUCL* 18,695,2000
TOXICOLOGY REVIEWNEUCL* 23,397,2005
TOXICOLOGY REVIEWNBREV* 5,1,1981
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.5 ppm (4.1 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 5 ppm (40 mg/m3);KZW 20 ppm (160 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 50 ppm (410 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 5 ppm (40 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 1 ppm (8.2 mg/m3), short term exposure limit 3 ppm (25 mg/m3), NOV2011
Occupational Exposure Limit-GERMANYMAK 5 ppm (41 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 40 mg/m3, short term exposure limit 160 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 5 ppm (40 mg/m3), NOV2011
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.5 ppm, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 50 ppm (404 mg/m3), 0,5 mg/m3 (inhal), JUL2005
Occupational Exposure Limit-POLANDtime-weighted average 40 mg/m3, short term exposure limit 100 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 20 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 5 ppm (40 mg/m3);short term exposure limit 10 ppm (80 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 5 ppm (40 mg/m3), KZG-week 40 ppm (320 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 40 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 10 ppm (82 mg/m3), OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO HALOTHANE-airceiling concentration 2 ppm/60MNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 82943; Number of Industries 3; Total Number of Facilities 4118; Number of Occupations 15; Total Number of Employees Exposed 94682; Total Number of Female Employees Exposed 76108
National Occupational Hazard Survey 1974Hazard Code 82943; Number of Industries 2; Total Number of Facilities 806; Number of Occupations 8; Total Number of Employees Exposed 9490

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse; V79 cell culture-gene mutation
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-reversion
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #29

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